tacrolimus and Anemia--Refractory

tacrolimus has been researched along with Anemia--Refractory* in 3 studies

Reviews

1 review(s) available for tacrolimus and Anemia--Refractory

Article	Year
Myelodysplastic syndrome with trisomy 8 associated with Behçet syndrome: an immunologic link to a karyotypic abnormality. Pediatric blood & cancer, 2008, Volume: 50, Issue:3 Myelodysplastic syndrome (MDS) in children is often associated with chromosomal anomalies and trisomy 8 is a characteristic karyotypic feature in up to 20% of the cases. Behçet disease is a rare multisystem inflammatory disorder characterized by recurrent mouth and genital ulcers. MDS with trisomy 8 has been observed in adult patients with Behçet syndrome with some cases developing prior to the clinical manifestations of the latter. We present a female with a similar association and explain the importance of identifying the coexisting conditions. The immunological abnormalities, which may be observed in MDS and their possible mechanisms, are also discussed. Topics: Adolescent; Anemia, Refractory; Behcet Syndrome; Chromosomes, Human, Pair 8; Female; Humans; Immunologic Deficiency Syndromes; Immunosuppressive Agents; Karyotyping; Oral Ulcer; Tacrolimus; Thalidomide; Trisomy	2008

Article

Year

Myelodysplastic syndrome with trisomy 8 associated with Behçet syndrome: an immunologic link to a karyotypic abnormality.

Pediatric blood & cancer, 2008, Volume: 50, Issue:3

Myelodysplastic syndrome (MDS) in children is often associated with chromosomal anomalies and trisomy 8 is a characteristic karyotypic feature in up to 20% of the cases. Behçet disease is a rare multisystem inflammatory disorder characterized by recurrent mouth and genital ulcers. MDS with trisomy 8 has been observed in adult patients with Behçet syndrome with some cases developing prior to the clinical manifestations of the latter. We present a female with a similar association and explain the importance of identifying the coexisting conditions. The immunological abnormalities, which may be observed in MDS and their possible mechanisms, are also discussed.

Topics: Adolescent; Anemia, Refractory; Behcet Syndrome; Chromosomes, Human, Pair 8; Female; Humans; Immunologic Deficiency Syndromes; Immunosuppressive Agents; Karyotyping; Oral Ulcer; Tacrolimus; Thalidomide; Trisomy

2008

Other Studies

2 other study(ies) available for tacrolimus and Anemia--Refractory

Article	Year
Complete response to tacrolimus in a child with severe aplastic anemia resistant to cyclosporin A. Pediatric blood & cancer, 2009, Volume: 52, Issue:4 Aplastic anemia (AA) is a rare disorder in children, usually treated with immunosuppressive therapy (IST) including antithymocyte globulin (ATG) and cyclosporin A. There are no current widely used alternative therapies with comparable efficacy. We describe a child with severe aplastic anemia (SAA), who developed severe gingival hyperplasia secondary to cyclosporin A, unresponsive to intensive dental intervention. When IST was changed to tacrolimus there was a significant improvement in the gingival hyperplasia, but equally important, he achieved complete response of his AA within several months. The use of tacrolimus in children with AA may be a potential modality of treatment. Topics: Anemia, Aplastic; Anemia, Refractory; Child; Cyclosporine; Gingival Hyperplasia; Humans; Immunosuppressive Agents; Male; Tacrolimus	2009
Successful treatment using tacrolimus plus corticosteroid in a patient with RA associated with MDS. Rheumatology international, 2008, Volume: 28, Issue:5 We report a case of rheumatoid arthritis (RA) complicated by myelodysplastic syndrome (MDS) successfully treated by tacrolimus. A 57-year-old woman had persistent pain and swelling in bilateral wrist and knee joints, in addition to severe anemia and leukopenia. She was diagnosed with MDS and RA based on the results of bone marrow aspiration and the criteria of RA. Combination therapy with tacrolimus (1.5 mg day(-1)) and prednisolone (10 mg day(-1)) improved her bicytopenia and polyarthralgia. Topics: Anemia, Refractory; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Middle Aged; Prednisolone; Tacrolimus	2008

Article

Year

Complete response to tacrolimus in a child with severe aplastic anemia resistant to cyclosporin A.

Pediatric blood & cancer, 2009, Volume: 52, Issue:4

Aplastic anemia (AA) is a rare disorder in children, usually treated with immunosuppressive therapy (IST) including antithymocyte globulin (ATG) and cyclosporin A. There are no current widely used alternative therapies with comparable efficacy. We describe a child with severe aplastic anemia (SAA), who developed severe gingival hyperplasia secondary to cyclosporin A, unresponsive to intensive dental intervention. When IST was changed to tacrolimus there was a significant improvement in the gingival hyperplasia, but equally important, he achieved complete response of his AA within several months. The use of tacrolimus in children with AA may be a potential modality of treatment.

Topics: Anemia, Aplastic; Anemia, Refractory; Child; Cyclosporine; Gingival Hyperplasia; Humans; Immunosuppressive Agents; Male; Tacrolimus

2009

Successful treatment using tacrolimus plus corticosteroid in a patient with RA associated with MDS.

Rheumatology international, 2008, Volume: 28, Issue:5

We report a case of rheumatoid arthritis (RA) complicated by myelodysplastic syndrome (MDS) successfully treated by tacrolimus. A 57-year-old woman had persistent pain and swelling in bilateral wrist and knee joints, in addition to severe anemia and leukopenia. She was diagnosed with MDS and RA based on the results of bone marrow aspiration and the criteria of RA. Combination therapy with tacrolimus (1.5 mg day(-1)) and prednisolone (10 mg day(-1)) improved her bicytopenia and polyarthralgia.

Topics: Anemia, Refractory; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Middle Aged; Prednisolone; Tacrolimus

2008