tacrine has been researched along with Tremor in 17 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine the mechanisms underlying the anti-tremor effect of zonisamide in rats under conditions of tacrine-induced tremulous jaw movements (TJMs)." | 7.75 | Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect. ( Kondo, T; Kubo, T; Miwa, H; Suzuki, A, 2009) |
| "Effect of zonisamide on harmaline- or oxotreorine-induced tremors, and tacrine-induced tremulous jaw movements (TJMs) was studied." | 7.74 | Effects of zonisamide on experimental tremors in rats. ( Hama, K; Kajimoto, Y; Kondo, T; Miwa, H, 2008) |
| "Tacrine is a potent and reversible inhibitor of acetylcholinesterase (AChE) in the brain." | 5.33 | Evidence for the involvement of central serotonergic mechanisms in cholinergic tremor induced by tacrine in Balb/c mice. ( Haobam, R; Mehta, H; Mohanakumar, KP; Usha, R, 2005) |
| " Intact male GPR88 KO mice showed diminished tacrine-induced PD-like tremor and spontaneous hyperlocomotion." | 3.96 | Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia. ( Mannoury-la-Cour, C; Mantas, I; Millan, MJ; Svenningsson, P; Yang, Y; Zhang, X, 2020) |
| "We examined the effects of two dopamine agonists, cabergoline and rotigotine, on tacrine-induced tremor and c-Fos expression in rats." | 3.80 | Effects of cabergoline and rotigotine on tacrine-induced tremulous jaw movements in rats. ( Abe, H; Ebihara, K; Funahashi, H; Ikeda, T; Ishida, Y; Koganemaru, G; Kuramashi, A; Matsuo, H; Nishimori, T; Yasuda, K, 2014) |
| "To examine the mechanisms underlying the anti-tremor effect of zonisamide in rats under conditions of tacrine-induced tremulous jaw movements (TJMs)." | 3.75 | Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect. ( Kondo, T; Kubo, T; Miwa, H; Suzuki, A, 2009) |
| ") proved capable of reducing jaw tremors in tacrine model of Parkinson's disease tremor." | 3.74 | Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats. ( Borsini, F; Carminati, P; Frau, L; Morelli, M; Schintu, N; Simola, N; Tronci, E, 2007) |
| "Effect of zonisamide on harmaline- or oxotreorine-induced tremors, and tacrine-induced tremulous jaw movements (TJMs) was studied." | 3.74 | Effects of zonisamide on experimental tremors in rats. ( Hama, K; Kajimoto, Y; Kondo, T; Miwa, H, 2008) |
| " The effects of adenosine A(2A) receptor antagonists were here assessed in a rat model of parkinsonian tremor induced by cholinomimetic drugs by evaluating the counteraction of tremulous jaw movements." | 3.73 | Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease. ( Baraldi, PG; Fenu, S; Morelli, M; Simola, N; Tabrizi, MA, 2006) |
| " The non-selective muscarinic agonists pilocarpine, oxotremorine, RS-86, S-aceclidine, but not the less active isomer R-aceclidine, also effectively stimulated PI hydrolysis in mice." | 3.70 | Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects. ( Bymaster, FP; Calligaro, DO; Carter, PA; DeLapp, N; Fink-Jensen, A; Jeppesen, L; Mitch, CH; Peters, SC; Rimvall, K; Sauerberg, P; Shannon, HE; Sheardown, MJ; Ward, JS; Whitesitt, CA; Zhang, W, 1998) |
| " The present study investigated the dose-response characteristics of donepezil, tacrine, rivastigmine and metrifonate in inducing tremor, lacrimation, salivation and hypothermia and the duration of action of these compounds in Lister hooded rats." | 3.70 | Comparison of donepezil-, tacrine-, rivastigmine- and metrifonate-induced central and peripheral cholinergically mediated responses in the rat. ( Dronfield, S; Egan, K; Green, AR; Marsden, CA, 2000) |
| "Tacrine disposition was maintained with age, and area under the concentration-time curve and clearance in old rats were similar to those in young rats for all drugs tested as was bioavailability." | 1.37 | Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. ( Aw, CC; Browne, ER; Chen, CP; Goh, CW; Lee, JH, 2011) |
| "Tacrine is a potent and reversible inhibitor of acetylcholinesterase (AChE) in the brain." | 1.33 | Evidence for the involvement of central serotonergic mechanisms in cholinergic tremor induced by tacrine in Balb/c mice. ( Haobam, R; Mehta, H; Mohanakumar, KP; Usha, R, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 9 (52.94) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Mantas, I | 1 |
| Yang, Y | 1 |
| Mannoury-la-Cour, C | 1 |
| Millan, MJ | 1 |
| Zhang, X | 1 |
| Svenningsson, P | 1 |
| Pinna, A | 1 |
| Bonaventura, J | 1 |
| Farré, D | 1 |
| Sánchez, M | 1 |
| Simola, N | 3 |
| Mallol, J | 1 |
| Lluís, C | 1 |
| Costa, G | 1 |
| Baqi, Y | 1 |
| Müller, CE | 1 |
| Cortés, A | 1 |
| McCormick, P | 1 |
| Canela, EI | 1 |
| Martínez-Pinilla, E | 1 |
| Lanciego, JL | 1 |
| Casadó, V | 1 |
| Armentero, MT | 1 |
| Franco, R | 1 |
| Koganemaru, G | 1 |
| Abe, H | 1 |
| Kuramashi, A | 1 |
| Ebihara, K | 1 |
| Matsuo, H | 1 |
| Funahashi, H | 1 |
| Yasuda, K | 1 |
| Ikeda, T | 1 |
| Nishimori, T | 1 |
| Ishida, Y | 1 |
| Miwa, H | 2 |
| Kubo, T | 1 |
| Suzuki, A | 1 |
| Kondo, T | 2 |
| Trevitt, J | 1 |
| Kawa, K | 1 |
| Jalali, A | 1 |
| Larsen, C | 1 |
| Goh, CW | 1 |
| Aw, CC | 1 |
| Lee, JH | 1 |
| Chen, CP | 1 |
| Browne, ER | 1 |
| Carlson, BB | 2 |
| Wisniecki, A | 1 |
| Salamone, JD | 3 |
| Mehta, H | 1 |
| Haobam, R | 1 |
| Usha, R | 1 |
| Mohanakumar, KP | 1 |
| Fenu, S | 1 |
| Baraldi, PG | 1 |
| Tabrizi, MA | 1 |
| Morelli, M | 2 |
| Tronci, E | 1 |
| Borsini, F | 1 |
| Schintu, N | 1 |
| Frau, L | 1 |
| Carminati, P | 1 |
| Hama, K | 1 |
| Kajimoto, Y | 1 |
| Yoshida, S | 1 |
| Suzuki, N | 1 |
| Bessho, T | 1 |
| Takashina, K | 1 |
| Tabata, R | 1 |
| Ohshima, C | 1 |
| Chaki, H | 1 |
| Yamabe, H | 1 |
| Egawa, M | 1 |
| Tobe, A | 1 |
| Saito, K | 1 |
| Mayorga, AJ | 1 |
| Carriero, DL | 1 |
| Cousins, MS | 1 |
| Gianutsos, G | 1 |
| Bymaster, FP | 1 |
| Carter, PA | 1 |
| Peters, SC | 1 |
| Zhang, W | 1 |
| Ward, JS | 1 |
| Mitch, CH | 1 |
| Calligaro, DO | 1 |
| Whitesitt, CA | 1 |
| DeLapp, N | 1 |
| Shannon, HE | 1 |
| Rimvall, K | 1 |
| Jeppesen, L | 1 |
| Sheardown, MJ | 1 |
| Fink-Jensen, A | 1 |
| Sauerberg, P | 1 |
| Trevitt, JT | 1 |
| Dronfield, S | 1 |
| Egan, K | 1 |
| Marsden, CA | 1 |
| Green, AR | 1 |
17 other studies available for tacrine and Tremor
| Article | Year |
|---|---|
Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Cholinesterase Inhibitors; Corpus Striatum; Dopami | 2020 |
L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Cannabinoid Receptor Antagonists; | 2014 |
Effects of cabergoline and rotigotine on tacrine-induced tremulous jaw movements in rats.
Topics: Animals; Cabergoline; Corpus Striatum; Dopamine Agonists; Dose-Response Relationship, Drug; Ergoline | 2014 |
Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect.
Topics: Animals; Anticonvulsants; Brain; Cell Count; Disease Models, Animal; Dose-Response Relationship, Dru | 2009 |
Differential effects of adenosine antagonists in two models of parkinsonian tremor.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; | 2009 |
Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats.
Topics: Aging; Animals; Biological Availability; Brain; Cholinesterase Inhibitors; Cholinesterases; Donepezi | 2011 |
Local injections of the 5-hydroxytryptamine antagonist mianserin into substantia nigra pars reticulata block tremulous jaw movements in rats: studies with a putative model of Parkinsonian tremor.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injections; | 2003 |
Evidence for the involvement of central serotonergic mechanisms in cholinergic tremor induced by tacrine in Balb/c mice.
Topics: Acetylcholine; Analysis of Variance; Animals; Atropine; Behavior, Animal; Biogenic Amines; Brain; Br | 2005 |
Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease.
Topics: Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Rela | 2006 |
Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Adrenergic Agents; Animals; Antiparkinson Agents; Behavi | 2007 |
Effects of zonisamide on experimental tremors in rats.
Topics: Animals; Anticonvulsants; Central Nervous System Stimulants; Cholinesterase Inhibitors; Harmaline; I | 2008 |
Antiamnesic and cholinomimetic side-effects of the cholinesterase inhibitors, physostigmine, tacrine and NIK-247 in rats.
Topics: Administration, Oral; Aminoquinolines; Amnesia; Animals; Avoidance Learning; Body Temperature; Choli | 1993 |
Effect of the novel high affinity choline uptake enhancer 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b] quinolin-4-yl)acetoamide on deficits of water maze learning in rats.
Topics: Acetylcholinesterase; Animals; Aziridines; Body Temperature; Choline; Hippocampus; In Vitro Techniqu | 1996 |
Tremulous jaw movements produced by acute tacrine administration: possible relation to parkinsonian side effects.
Topics: Animals; Corpus Striatum; Dose-Response Relationship, Drug; Jaw; Male; Muscarinic Antagonists; Paras | 1997 |
Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects.
Topics: Animals; Binding, Competitive; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic | 1998 |
Effects of H1 antagonists on cholinomimetic-induced tremulous jaw movements: studies of diphenhydramine, doxepin, and mepyramine.
Topics: Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzodiazepines; Cholinergic Agents | 2000 |
Comparison of donepezil-, tacrine-, rivastigmine- and metrifonate-induced central and peripheral cholinergically mediated responses in the rat.
Topics: Animals; Body Temperature; Carbamates; Cholinesterase Inhibitors; Donepezil; Dose-Response Relations | 2000 |