tacrine has been researched along with Sensitivity and Specificity in 19 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a cost-analysis model, the effect on the costs of Alzheimer disease of tacrine (tetrahydroaminoacridine) treatment was studied." | 7.69 | Treatment of Alzheimer disease with tacrine: a cost-analysis model. ( Karlsson, G; Nordberg, A; Wimo, A; Winblad, B, 1997) |
| "In a cost-analysis model, the effect on the costs of Alzheimer disease of tacrine (tetrahydroaminoacridine) treatment was studied." | 3.69 | Treatment of Alzheimer disease with tacrine: a cost-analysis model. ( Karlsson, G; Nordberg, A; Wimo, A; Winblad, B, 1997) |
| " The method was successfully applied to a pharmacokinetic study involving intramuscular application of 3." | 1.43 | An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study. ( Korabecny, J; Kuca, K; Mzik, M; Nepovimova, E; Palička, V; Voříšek, V; Zdarova Karasova, J, 2016) |
| " The aim of the present work was to develop and validate an LC-MS/MS method with electrospray ionization for the quantification of T6FA in rat plasma using tacrine-3-ferulic acid (T3FA) as internal standard and to examine its application for pharmacokinetic study in rats." | 1.40 | Determination of tacrine-6-ferulic acid in rat plasma by LC-MS/MS and its application to pharmacokinetics study. ( Deng, X; Liao, Q; Pi, R; Sun, X; Xie, Z; Zhang, P; Zhou, Y, 2014) |
| " The type of inhibition (competitive, uncompetitive, or mixed), the dissociation constants for the inhibitors, and the inhibitor dose-response curves were also determined." | 1.33 | Automated method, based on micro-sequential injection, for the study of enzyme kinetics and inhibition. ( Carroll, AD; Chen, Y; Ruzicka, J; Scampavia, L, 2006) |
| "Clinical trials with tacrine (THA) and its principal (1-OH) metabolite (velnacrine) for the treatment of Alzheimer's disease have been hampered by adverse hepatic events that were undetected in preclinical studies." | 1.29 | Cytotoxicity of tacrine and velnacrine metabolites in cultured rat, dog and human hepatocytes. ( Curren, RD; Viau, CJ; Wallace, K, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 9 (47.37) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Szymanski, P | 1 |
| Karpiński, A | 1 |
| Mikiciuk-Olasik, E | 1 |
| Sun, X | 1 |
| Zhang, P | 1 |
| Pi, R | 1 |
| Zhou, Y | 1 |
| Deng, X | 1 |
| Xie, Z | 1 |
| Liao, Q | 1 |
| Mzik, M | 1 |
| Korabecny, J | 1 |
| Nepovimova, E | 1 |
| Voříšek, V | 1 |
| Palička, V | 1 |
| Kuca, K | 1 |
| Zdarova Karasova, J | 1 |
| Youdim, KA | 1 |
| Lyons, R | 1 |
| Payne, L | 1 |
| Jones, BC | 1 |
| Saunders, K | 1 |
| Jiang, Y | 1 |
| Zhang, Y | 1 |
| Zhang, ZR | 1 |
| Getova, DP | 1 |
| Dimitrova, DS | 1 |
| Chen, Y | 1 |
| Carroll, AD | 1 |
| Scampavia, L | 1 |
| Ruzicka, J | 1 |
| Delfini, M | 1 |
| Di Cocco, ME | 1 |
| Piccioni, F | 1 |
| Porcelli, F | 1 |
| Borioni, A | 1 |
| Rodomonte, A | 1 |
| Del Giudice, MR | 1 |
| Gainullina, ET | 1 |
| Kondratyev, KV | 1 |
| Ryzhikov, SB | 1 |
| Taranchenko, VF | 1 |
| Yu, H | 1 |
| Ho, JM | 1 |
| Kan, KK | 1 |
| Cheng, BW | 1 |
| Li, WM | 1 |
| Zhang, L | 1 |
| Lin, G | 1 |
| Pang, YP | 1 |
| Gu, ZM | 1 |
| Chan, K | 1 |
| Wang, YT | 1 |
| Han, YF | 1 |
| Wilcock, GK | 2 |
| Ashworth, DL | 1 |
| Langfield, JA | 1 |
| Smith, PM | 1 |
| Viau, CJ | 1 |
| Curren, RD | 1 |
| Wallace, K | 1 |
| Wimo, A | 1 |
| Karlsson, G | 1 |
| Nordberg, A | 1 |
| Winblad, B | 1 |
| Vargas, MG | 1 |
| Havel, J | 1 |
| Patocka, J | 1 |
| Hansen, LL | 1 |
| Larsen, JT | 1 |
| Brøsen, K | 1 |
| Aymard, G | 1 |
| Cayre-Castel, M | 1 |
| Fernandez, C | 1 |
| Lacomblez, L | 1 |
| Diquet, B | 1 |
| Sands, LP | 1 |
| Katz, I | 1 |
| Schneider, L | 1 |
| Byrne, LM | 1 |
| Wilson, PM | 1 |
| Bucks, RS | 1 |
| Hughes, AO | 1 |
| Werber, AE | 1 |
| Klein, C | 1 |
| Rabey, JM | 1 |
1 trial available for tacrine and Sensitivity and Specificity
| Article | Year |
|---|---|
Assessing individual patients for cognitive benefits from acetylcholinesterase inhibitors.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Female; Humans; Male; Mental Status S | 1999 |
18 other studies available for tacrine and Sensitivity and Specificity
| Article | Year |
|---|---|
Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Benzoates; Butyrylcholinesterase; Cholinesterase | 2011 |
Determination of tacrine-6-ferulic acid in rat plasma by LC-MS/MS and its application to pharmacokinetics study.
Topics: Animals; Chromatography, Liquid; Coumaric Acids; Drug Stability; Linear Models; Male; Rats; Rats, Sp | 2014 |
An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepez | 2016 |
An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point.
Topics: Aryl Hydrocarbon Hydroxylases; Biological Assay; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cy | 2008 |
Simultaneous determination of N-butyramide-tacrine and tacrine in mouse plasma and brain homogenate by high-performance liquid chromatography with a simple gradient solvent system.
Topics: Animals; Brain; Calibration; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Mice; | 2003 |
Effects of the anticholinesterase drug tacrine on the development of PTZ kindling and on learning and memory processes in mice.
Topics: Analysis of Variance; Animals; Avoidance Learning; Cholinesterase Inhibitors; Disease Models, Animal | 2000 |
Automated method, based on micro-sequential injection, for the study of enzyme kinetics and inhibition.
Topics: Acetylcholinesterase; Autoanalysis; Dipeptides; Dose-Response Relationship, Drug; Edrophonium; Flow | 2006 |
Tacrine derivatives-acetylcholinesterase interaction: 1H NMR relaxation study.
Topics: Acetylcholinesterase; Enzyme Activation; Ligands; Magnetic Resonance Spectroscopy; Molecular Structu | 2007 |
Fluorescent method for evaluation of cholinesterase inhibitors.
Topics: Animals; Buffers; Butyrylcholinesterase; Butyrylthiocholine; Cholinesterase Inhibitors; Coumarins; D | 2006 |
Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood.
Topics: Alzheimer Disease; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Drug Stability; | 2007 |
Detecting patients with Alzheimer's disease suitable for drug treatment: comparison of three methods of assessment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; England; Family Practice; Female; Geriatric Assessment; | 1994 |
Cytotoxicity of tacrine and velnacrine metabolites in cultured rat, dog and human hepatocytes.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cells, Cultur | 1993 |
Treatment of Alzheimer disease with tacrine: a cost-analysis model.
Topics: Alzheimer Disease; Cost-Benefit Analysis; Health Care Costs; Humans; Models, Theoretical; Psychologi | 1997 |
Capillary zone electrophoretic determination of some drugs against Alzheimer's disease.
Topics: Alzheimer Disease; Calibration; Cholinesterase Inhibitors; Electrophoresis, Capillary; Hydrogen-Ion | 1998 |
Determination of tacrine and its metabolites in human plasma and urine by high-performance liquid chromatography and fluorescence detection.
Topics: Acetates; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Humans; Reproducibility o | 1998 |
High-performance liquid chromatography with ultraviolet and fluorimetric detection for the simultaneous determination of tacrine, nimodipine, and their respective metabolites in the plasma of patients with Alzheimer disease.
Topics: Alzheimer Disease; Calibration; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Dru | 1998 |
The sensitivity to change over time of the Bristol Activities of Daily Living Scale in Alzheimer's disease.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Clinical Trials as Topic; Fe | 2000 |
Evaluation of cholinergic treatment in demented patients by P300 evoked related potentials.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Carbamates; Cholinesterase Inhibit | 2001 |