tacrine has been researched along with Seizures in 9 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tacrine and LiCl were ineffective when given individually." | 5.28 | Tacrine-induced seizures and brain damage in LiCl-treated rats can be prevented by N omega-nitro-L-arginine methyl ester. ( Bagetta, G; Iannone, M; Nisticò, G; Scorsa, AM, 1992) |
| "Administration of tacrine (5 mg/kg ip), an anticholinesterase agent, in rats pretreated (24 h beforehand) with lithium chloride (LiCl; 12 mEq/kg ip) provides a useful experimental model to study limbic seizures and delayed hippocampal damage." | 3.71 | Abnormal expression of neuronal nitric oxide synthase triggers limbic seizures and hippocampal damage in rat. ( Bagetta, G; Corasaniti, MT; Del Duca, C; Leta, A; Nisticò, R; Paoletti, AM; Rotiroti, D, 2002) |
| "Tacrine and LiCl were ineffective when given individually." | 1.28 | Tacrine-induced seizures and brain damage in LiCl-treated rats can be prevented by N omega-nitro-L-arginine methyl ester. ( Bagetta, G; Iannone, M; Nisticò, G; Scorsa, AM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bezerra da Silva, C | 1 |
| Pott, A | 1 |
| Elifio-Esposito, S | 1 |
| Dalarmi, L | 1 |
| Fialho do Nascimento, K | 1 |
| Moura Burci, L | 1 |
| de Oliveira, M | 1 |
| de Fátima Gaspari Dias, J | 1 |
| Warumby Zanin, SM | 1 |
| Gomes Miguel, O | 1 |
| Dallarmi Miguel, M | 1 |
| Bagetta, G | 5 |
| Iannone, M | 2 |
| Palma, E | 1 |
| Rodinò, P | 2 |
| Granato, T | 1 |
| Nisticò, G | 4 |
| Massoud, R | 1 |
| Federici, G | 1 |
| Lebert, F | 1 |
| Hasenbroekx, C | 1 |
| Pasquier, F | 1 |
| Petit, H | 1 |
| Paoletti, AM | 2 |
| Piccirilli, S | 1 |
| Costa, N | 1 |
| Rotiroti, D | 2 |
| García-Díaz, JD | 1 |
| Fraguas, C | 1 |
| Garcimartín, C | 1 |
| Leta, A | 1 |
| Del Duca, C | 1 |
| Nisticò, R | 1 |
| Corasaniti, MT | 1 |
| Scorsa, AM | 1 |
| Herink, J | 1 |
| Koupilová, M | 1 |
| Hrdina, V | 1 |
9 other studies available for tacrine and Seizures
| Article | Year |
|---|---|
Effect of Donepezil, Tacrine, Galantamine and Rivastigmine on Acetylcholinesterase Inhibition in Dugesia tigrina.
Topics: Animals; Cholinesterase Inhibitors; Convulsants; Donepezil; Galantamine; Indans; Locomotion; Models, | 2016 |
Lack of involvement of nitric oxide in the mechanisms of seizures and hippocampal damage produced by kainate and ouabain in rats.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Brain Damage, Chronic; Hippocampus; Kainic Acid; Lith | 1995 |
Systemic administration of lithium chloride and tacrine increases nitric oxide synthase activity in the hippocampus of rats.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Atropine; Cerebral Cortex; Chlorides; Cyclic GMP; Hip | 1993 |
Convulsive effects of tacrine.
Topics: Aged; Alzheimer Disease; Female; Humans; Male; Nootropic Agents; Seizures; Tacrine | 1996 |
Systemic administration of N omega-nitro-L-arginine methyl ester and indomethacin reduces the elevation of brain PGE2 content and prevents seizures and hippocampal damage evoked by LiCl and tacrine in rat.
Topics: Animals; Cholinesterase Inhibitors; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Hippocampus; I | 1998 |
[Convulsive crisis as a possible adverse reaction to the treatment with tacrine in Alzheimer's disease].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Female; Follow-Up Studies; Hu | 1998 |
Abnormal expression of neuronal nitric oxide synthase triggers limbic seizures and hippocampal damage in rat.
Topics: Animals; Blotting, Western; Cholinesterase Inhibitors; Enzyme Inhibitors; Hippocampus; Indazoles; Li | 2002 |
Tacrine-induced seizures and brain damage in LiCl-treated rats can be prevented by N omega-nitro-L-arginine methyl ester.
Topics: Animals; Arginine; Brain; Chlorides; Lithium; Lithium Chloride; Male; NG-Nitroarginine Methyl Ester; | 1992 |
Effects of tetrahydroaminoacridine (tacrine) derivatives and physostigmine in convulsions induced by pentylenetetrazol.
Topics: Aminoacridines; Animals; Cholinesterase Inhibitors; Male; Pentylenetetrazole; Physostigmine; Rats; R | 1989 |