tacrine has been researched along with Protein Aggregation, Pathological in 8 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Protein Aggregation, Pathological: A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION; POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lan, JS | 1 |
| Xie, SS | 1 |
| Li, SY | 1 |
| Pan, LF | 1 |
| Wang, XB | 1 |
| Kong, LY | 1 |
| Guzior, N | 1 |
| Bajda, M | 2 |
| Skrok, M | 1 |
| Kurpiewska, K | 1 |
| Lewiński, K | 1 |
| Brus, B | 1 |
| Pišlar, A | 1 |
| Kos, J | 1 |
| Gobec, S | 2 |
| Malawska, B | 2 |
| Panek, D | 1 |
| Więckowska, A | 1 |
| Wichur, T | 1 |
| Godyń, J | 1 |
| Jończyk, J | 1 |
| Mika, K | 1 |
| Janockova, J | 1 |
| Soukup, O | 1 |
| Knez, D | 1 |
| Korabecny, J | 1 |
| Joubert, J | 1 |
| Foka, GB | 1 |
| Repsold, BP | 1 |
| Oliver, DW | 1 |
| Kapp, E | 1 |
| Malan, SF | 1 |
| Hiremathad, A | 2 |
| Keri, RS | 2 |
| Esteves, AR | 1 |
| Cardoso, SM | 2 |
| Chaves, S | 3 |
| Santos, MA | 2 |
| Du, H | 1 |
| Jiang, X | 1 |
| Ma, M | 1 |
| Xu, H | 1 |
| Liu, S | 1 |
| Ma, F | 1 |
| Rajeshwari, R | 1 |
| Chand, K | 1 |
| Candeias, E | 1 |
8 other studies available for tacrine and Protein Aggregation, Pathological
| Article | Year |
|---|---|
Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain B | 2014 |
Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzylamines; Cell Line, Tumor; Cholinesterase Inhibito | 2015 |
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.
Topics: Amines; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Binding Sites; Blood-Brain Barr | 2017 |
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzyl Compounds; Binding Sites; Cholinesterase I | 2017 |
Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzimidazoles; Cholinesterase Inhibitors; Humans; Neurode | 2018 |
Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Carbolines; Cell Line; Ch | 2020 |
Multi-Targeting Tacrine Conjugates with Cholinesterase and Amyloid-Beta Inhibitory Activities: New Anti-Alzheimer's Agents.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Caco-2 Cells; Cholinesterase Inhibitors; Cholinesterases; | 2021 |
New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors | 2019 |