tacrine has been researched along with Parkinsonian Disorders in 7 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Parkinsonian Disorders: A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Intact male GPR88 KO mice showed diminished tacrine-induced PD-like tremor and spontaneous hyperlocomotion." | 3.96 | Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia. ( Mannoury-la-Cour, C; Mantas, I; Millan, MJ; Svenningsson, P; Yang, Y; Zhang, X, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Mantas, I | 1 |
| Yang, Y | 1 |
| Mannoury-la-Cour, C | 1 |
| Millan, MJ | 1 |
| Zhang, X | 1 |
| Svenningsson, P | 1 |
| Pinna, A | 1 |
| Bonaventura, J | 1 |
| Farré, D | 1 |
| Sánchez, M | 1 |
| Simola, N | 2 |
| Mallol, J | 1 |
| Lluís, C | 1 |
| Costa, G | 1 |
| Baqi, Y | 1 |
| Müller, CE | 1 |
| Cortés, A | 1 |
| McCormick, P | 1 |
| Canela, EI | 1 |
| Martínez-Pinilla, E | 1 |
| Lanciego, JL | 1 |
| Casadó, V | 1 |
| Armentero, MT | 1 |
| Franco, R | 1 |
| Trevitt, J | 1 |
| Kawa, K | 1 |
| Jalali, A | 1 |
| Larsen, C | 1 |
| Yao, L | 1 |
| Li, W | 1 |
| She, H | 1 |
| Dou, J | 1 |
| Jia, L | 1 |
| He, Y | 1 |
| Yang, Q | 1 |
| Zhu, J | 1 |
| Cápiro, NL | 1 |
| Walker, DI | 1 |
| Pennell, KD | 1 |
| Pang, Y | 1 |
| Liu, Y | 1 |
| Han, Y | 1 |
| Mao, Z | 1 |
| Carlson, BB | 2 |
| Wisniecki, A | 2 |
| Salamone, JD | 2 |
| Fenu, S | 1 |
| Baraldi, PG | 1 |
| Tabrizi, MA | 1 |
| Morelli, M | 1 |
| Rios, C | 1 |
| Lentini, E | 1 |
| Correa, M | 1 |
| Betz, A | 1 |
7 other studies available for tacrine and Parkinsonian Disorders
| Article | Year |
|---|---|
Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Cholinesterase Inhibitors; Corpus Striatum; Dopami | 2020 |
L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Cannabinoid Receptor Antagonists; | 2014 |
Differential effects of adenosine antagonists in two models of parkinsonian tremor.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; | 2009 |
Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Behav | 2012 |
Local injections of the 5-hydroxytryptamine antagonist mianserin into substantia nigra pars reticulata block tremulous jaw movements in rats: studies with a putative model of Parkinsonian tremor.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injections; | 2003 |
Blockade of adenosine A2A receptors antagonizes parkinsonian tremor in the rat tacrine model by an action on specific striatal regions.
Topics: Adenosine A2 Receptor Antagonists; Animals; Behavior, Animal; Corpus Striatum; Disease Models, Anima | 2004 |
Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243.
Topics: Analysis of Variance; Animals; Cholinergic Agents; Disease Models, Animal; Dopamine Agonists; Dose-R | 2005 |