tacrine has been researched along with Parkinson Disease in 14 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of adenosine A(2A) receptor antagonists were here assessed in a rat model of parkinsonian tremor induced by cholinomimetic drugs by evaluating the counteraction of tremulous jaw movements." | 3.73 | Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease. ( Baraldi, PG; Fenu, S; Morelli, M; Simola, N; Tabrizi, MA, 2006) |
| "A patient with Alzheimer's disease and mild features of parkinsonism was treated with tacrine." | 1.28 | Exacerbation of parkinsonism by tacrine. ( Lannon, MC; Ott, BR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (64.29) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalli, A | 1 |
| Bolognesi, ML | 1 |
| Minarini, A | 1 |
| Rosini, M | 1 |
| Tumiatti, V | 1 |
| Recanatini, M | 1 |
| Melchiorre, C | 1 |
| Mohamed, T | 1 |
| Yeung, JC | 1 |
| Rao, PP | 1 |
| Kasture, S | 1 |
| Pontis, S | 1 |
| Pinna, A | 1 |
| Schintu, N | 1 |
| Spina, L | 1 |
| Longoni, R | 1 |
| Simola, N | 2 |
| Ballero, M | 1 |
| Morelli, M | 2 |
| Ringman, JM | 1 |
| Cummings, JL | 2 |
| Fenu, S | 1 |
| Baraldi, PG | 1 |
| Tabrizi, MA | 1 |
| Perry, EK | 1 |
| Haroutunian, V | 1 |
| Davis, KL | 1 |
| Levy, R | 2 |
| Lantos, P | 1 |
| Eagger, S | 1 |
| Honavar, M | 1 |
| Dean, A | 1 |
| Griffiths, M | 1 |
| McKeith, IG | 1 |
| Hutchinson, M | 1 |
| Fazzini, E | 1 |
| Gidal, BE | 1 |
| Crismon, ML | 1 |
| Wagner, ML | 1 |
| Fagan, SC | 1 |
| Privitera, MD | 1 |
| Dalmady-Israel, C | 1 |
| Graves, NM | 1 |
| Mayorga, AJ | 1 |
| Carriero, DL | 1 |
| Cousins, MS | 1 |
| Gianutsos, G | 1 |
| Salamone, JD | 1 |
| Scarbrough, TJ | 1 |
| Maloteaux, JM | 1 |
| Ott, BR | 1 |
| Lannon, MC | 1 |
5 reviews available for tacrine and Parkinson Disease
| Article | Year |
|---|---|
Multi-target-directed ligands to combat neurodegenerative diseases.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Binding Sites; Calcium | 2008 |
Current and emerging pharmacological treatment options for dementia.
Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Human | 2006 |
Dementia: the failing brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dementia; Dementia, Vascular; Humans; Middle Aged; Parki | 1995 |
Current developments in neurology, Part II: Advances in the pharmacotherapy of Alzheimer disease, Parkinson's disease, and stroke.
Topics: Alzheimer Disease; Anticoagulants; Apomorphine; Aspirin; Cerebrovascular Disorders; Cholinergic Agen | 1996 |
Diffuse Lewy body disease: a common yet misdiagnosed dementia in which neuroleptics may be contraindicated.
Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Brain; Cholinesterase Inhibitors; Contraindications; | 1998 |
2 trials available for tacrine and Parkinson Disease
| Article | Year |
|---|---|
Neocortical cholinergic activities differentiate Lewy body dementia from classical Alzheimer's disease.
Topics: Alzheimer Disease; Cerebral Cortex; Choline O-Acetyltransferase; Diagnosis, Differential; Humans; Pa | 1994 |
Cholinesterase inhibition in Parkinson's disease.
Topics: Aged; Cholinesterase Inhibitors; Dementia; Female; Humans; Male; Parkinson Disease; Pilot Projects; | 1996 |
7 other studies available for tacrine and Parkinson Disease
| Article | Year |
|---|---|
Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzhydryl Compounds; Butyrylcholinesterase; Cholineste | 2011 |
Assessment of symptomatic and neuroprotective efficacy of Mucuna pruriens seed extract in rodent model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Antiparkinson Agents; C | 2009 |
Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease.
Topics: Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Rela | 2006 |
Alzheimer's disease and Lewy body dementia.
Topics: Alzheimer Disease; Brain; Diagnosis, Differential; Humans; Lewy Bodies; Parkinson Disease; Tacrine | 1994 |
Tremulous jaw movements produced by acute tacrine administration: possible relation to parkinsonian side effects.
Topics: Animals; Corpus Striatum; Dose-Response Relationship, Drug; Jaw; Male; Muscarinic Antagonists; Paras | 1997 |
[Clinical pharmacology and therapeutic aspects in certain degenerative neurological diseases].
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Antiparkinson Agents; Cholinesterase Inhibitors; H | 1996 |
Exacerbation of parkinsonism by tacrine.
Topics: Aged; Alzheimer Disease; Electromyography; Female; Humans; Levodopa; Parkinson Disease; Tacrine | 1992 |