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tacrine and Neuromuscular Blockade

tacrine has been researched along with Neuromuscular Blockade in 3 studies

Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.

Neuromuscular Blockade: The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.

Research Excerpts

ExcerptRelevanceReference
"Tacrine (THA) is an anticholinesterase drug used to manage Alzheimer's dementia, but it is not clear how its chronic use might affect response to nondepolarizing muscle relaxants."1.30The effects of chronic tacrine therapy on d-tubocurarine blockade in the soleus and tibialis muscles of the rat. ( Donati, F; Eshelby, D; Fox, GS; Ibebunjo, C; Tchervenkov, JI, 1997)
"Tacrine is a cholinesterase inhibitor used to manage Alzheimer's dementia."1.30Tacrine does not alter the potency of succinylcholine in the rat. ( Donati, F; Eshelby, D; Fox, GS; Ibebunjo, C; Tchervenkov, JI, 1997)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tumiatti, V1
Rosini, M1
Bartolini, M1
Cavalli, A1
Marucci, G1
Andrisano, V1
Angeli, P1
Banzi, R1
Minarini, A1
Recanatini, M1
Melchiorre, C1
Ibebunjo, C2
Donati, F2
Fox, GS2
Eshelby, D2
Tchervenkov, JI2

Other Studies

3 other studies available for tacrine and Neuromuscular Blockade

ArticleYear
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
    Journal of medicinal chemistry, 2003, Mar-13, Volume: 46, Issue:6

    Topics: Acetylcholinesterase; Amides; Animals; Anisoles; Atrial Function; Butyrylcholinesterase; Cholinester

2003
The effects of chronic tacrine therapy on d-tubocurarine blockade in the soleus and tibialis muscles of the rat.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:2

    Topics: Administration, Oral; Alzheimer Disease; Anesthesia, General; Animals; Cholinesterase Inhibitors; Do

1997
Tacrine does not alter the potency of succinylcholine in the rat.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1997, Volume: 44, Issue:9

    Topics: Administration, Oral; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Dose-Response Relations

1997