tacrine has been researched along with Neuromuscular Blockade in 3 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Neuromuscular Blockade: The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tacrine (THA) is an anticholinesterase drug used to manage Alzheimer's dementia, but it is not clear how its chronic use might affect response to nondepolarizing muscle relaxants." | 1.30 | The effects of chronic tacrine therapy on d-tubocurarine blockade in the soleus and tibialis muscles of the rat. ( Donati, F; Eshelby, D; Fox, GS; Ibebunjo, C; Tchervenkov, JI, 1997) |
| "Tacrine is a cholinesterase inhibitor used to manage Alzheimer's dementia." | 1.30 | Tacrine does not alter the potency of succinylcholine in the rat. ( Donati, F; Eshelby, D; Fox, GS; Ibebunjo, C; Tchervenkov, JI, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tumiatti, V | 1 |
| Rosini, M | 1 |
| Bartolini, M | 1 |
| Cavalli, A | 1 |
| Marucci, G | 1 |
| Andrisano, V | 1 |
| Angeli, P | 1 |
| Banzi, R | 1 |
| Minarini, A | 1 |
| Recanatini, M | 1 |
| Melchiorre, C | 1 |
| Ibebunjo, C | 2 |
| Donati, F | 2 |
| Fox, GS | 2 |
| Eshelby, D | 2 |
| Tchervenkov, JI | 2 |
3 other studies available for tacrine and Neuromuscular Blockade
| Article | Year |
|---|---|
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
Topics: Acetylcholinesterase; Amides; Animals; Anisoles; Atrial Function; Butyrylcholinesterase; Cholinester | 2003 |
The effects of chronic tacrine therapy on d-tubocurarine blockade in the soleus and tibialis muscles of the rat.
Topics: Administration, Oral; Alzheimer Disease; Anesthesia, General; Animals; Cholinesterase Inhibitors; Do | 1997 |
Tacrine does not alter the potency of succinylcholine in the rat.
Topics: Administration, Oral; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Dose-Response Relations | 1997 |