tacrine has been researched along with Neuroblastoma in 22 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present paper reports data regarding the evaluation on the activity of monoamine-oxidase A and B in murine neuroblastoma cells carried out by a radioassay upon acute or chronic treatment of cells by aluminium or tacrine." | 7.70 | Evaluation of MAO activities on murine neuroblastoma cells upon acute or chronic treatment with aluminium (III) or tacrine. ( Nicosia, V; Zambenedetti, P; Zatta, P, 1998) |
| "The effect of chronic treatment with the cholinesterase inhibitor tacrine on nicotinic receptor subtypes was investigated in human SH-SY5Y neuroblastoma cells and in a fibroblast cell line (M10 cells) stably transfected with alpha4beta2 nicotinic receptors." | 7.70 | Tacrine interacts with different sites on nicotinic receptor subtypes in SH-SY5Y neuroblastoma and M10 cells. ( Svensson, AL, 2000) |
| " The present paper reports data regarding the evaluation on the activity of monoamine-oxidase A and B in murine neuroblastoma cells carried out by a radioassay upon acute or chronic treatment of cells by aluminium or tacrine." | 3.70 | Evaluation of MAO activities on murine neuroblastoma cells upon acute or chronic treatment with aluminium (III) or tacrine. ( Nicosia, V; Zambenedetti, P; Zatta, P, 1998) |
| " In silico predicted ADME and physicochemical properties of conjugates showed good CNS bioavailability and safety parameters." | 2.44 | Piperazine-2-carboxylic acid derivatives as MTDLs anti-Alzheimer agents: Anticholinesterase activity, mechanistic aspect, and molecular modeling studies. ( Abd El-Wahab, HAA; Akincioglu, H; Gülçin, İ; Omar, FA; Soliman, AM, 2024) |
| "Tacrine treatment did not alter the level of HSP-70 in cell extracts and tacrine affected mildly the secretion of PN-1." | 1.29 | Tacrine alters the secretion of the beta-amyloid precursor protein in cell lines. ( Farlow, MR; Lahiri, DK; Lewis, S, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (36.36) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 5 (22.73) | 24.3611 |
| 2020's | 4 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Marco-Contelles, J | 2 |
| León, R | 3 |
| de Los Ríos, C | 3 |
| Guglietta, A | 1 |
| Terencio, J | 1 |
| López, MG | 4 |
| García, AG | 4 |
| Villarroya, M | 4 |
| González-Muñoz, GC | 1 |
| Arce, MP | 1 |
| López, B | 1 |
| Pérez, C | 1 |
| Conde, S | 1 |
| Rodríguez-Franco, MI | 1 |
| Li, SY | 1 |
| Wang, XB | 1 |
| Xie, SS | 2 |
| Jiang, N | 2 |
| Wang, KD | 2 |
| Yao, HQ | 1 |
| Sun, HB | 1 |
| Kong, LY | 2 |
| Wang, X | 1 |
| Yu, W | 1 |
| Lan, JS | 1 |
| Li, ZR | 1 |
| Güleç, Ö | 1 |
| Türkeş, C | 1 |
| Arslan, M | 1 |
| Demir, Y | 1 |
| Yeni, Y | 1 |
| Hacımüftüoğlu, A | 1 |
| Ereminsoy, E | 1 |
| Küfrevioğlu, Öİ | 1 |
| Beydemir, Ş | 1 |
| Moreira, NCDS | 2 |
| Tamarozzi, ER | 2 |
| Lima, JEBF | 2 |
| Piassi, LO | 2 |
| Carvalho, I | 2 |
| Passos, GA | 2 |
| Sakamoto-Hojo, ET | 2 |
| Uliassi, E | 1 |
| Bergamini, C | 1 |
| Rizzardi, N | 1 |
| Naldi, M | 1 |
| Cores, Á | 1 |
| Bartolini, M | 1 |
| Carlos Menéndez, J | 1 |
| Bolognesi, ML | 1 |
| Soliman, AM | 1 |
| Abd El-Wahab, HAA | 1 |
| Akincioglu, H | 1 |
| Gülçin, İ | 1 |
| Omar, FA | 1 |
| Mitchell, RM | 1 |
| Lee, SY | 1 |
| Simmons, Z | 1 |
| Connor, JR | 1 |
| Muñoz-Torrero, D | 1 |
| Pera, M | 1 |
| Relat, J | 1 |
| Ratia, M | 1 |
| Galdeano, C | 1 |
| Viayna, E | 1 |
| Sola, I | 1 |
| Formosa, X | 1 |
| Camps, P | 1 |
| Badia, A | 1 |
| Clos, MV | 1 |
| Zhang, BF | 1 |
| Peng, FF | 1 |
| Zhang, JZ | 1 |
| Wu, DC | 1 |
| Orozco, C | 1 |
| Arias, E | 1 |
| Marco, JL | 1 |
| Lahiri, DK | 3 |
| Lewis, S | 1 |
| Farlow, MR | 3 |
| Walker, TM | 1 |
| Starr, B | 1 |
| Dewhurst, BB | 1 |
| Atterwill, C | 1 |
| Zatta, P | 2 |
| Zambenedetti, P | 2 |
| Marturano, MB | 1 |
| Palumbo, M | 1 |
| Nicolini, M | 1 |
| Nicosia, V | 1 |
| De Ferrari, GV | 1 |
| von Bernhardi, R | 1 |
| Calderón, FH | 1 |
| Luza, SC | 1 |
| Inestrosa, NC | 1 |
| Sambamurti, K | 1 |
| Svensson, AL | 1 |
| Robbins, J | 1 |
| Sim, JA | 1 |
22 other studies available for tacrine and Neuroblastoma
| Article | Year |
|---|---|
Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Calcium; Calcium Channels; Cell Prol | 2006 |
Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases.
Topics: Humans; Molecular Structure; Neuroblastoma; Neurodegenerative Diseases; Neuroprotective Agents; Oxid | 2010 |
Multifunctional tacrine-flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biphenyl Compounds; Cell Line, Tumo | 2013 |
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzopyrans; Blood-Brain Barrier; Brain; Cell Survival; Cel | 2015 |
Cytotoxic effect, enzyme inhibition, and in silico studies of some novel N-substituted sulfonyl amides incorporating 1,3,4-oxadiazol structural motif.
Topics: Acetazolamide; Acetylcholinesterase; Amides; Anticonvulsants; Antineoplastic Agents; Carbonic Anhydr | 2022 |
Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer's Disease Model.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Neuroblastoma | 2022 |
Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer's Disease Model.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Neuroblastoma | 2022 |
Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer's Disease Model.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Neuroblastoma | 2022 |
Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer's Disease Model.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Neuroblastoma | 2022 |
Quinolinetrione-tacrine hybrids as multi-target-directed ligands against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Cholinesterase Inhibit | 2023 |
Piperazine-2-carboxylic acid derivatives as MTDLs anti-Alzheimer agents: Anticholinesterase activity, mechanistic aspect, and molecular modeling studies.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Carboxylic Acids; Cholinest | 2024 |
HFE polymorphisms affect cellular glutamate regulation.
Topics: Analysis of Variance; Calcium; Cell Line, Tumor; Deferoxamine; Enzyme Inhibitors; Ferric Compounds; | 2011 |
Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents.
Topics: Aminoquinolines; Analysis of Variance; Animals; Cell Line, Tumor; Cell Survival; Dose-Response Relat | 2012 |
[Protective effects of tacrine and donepezil against staurosporine-induced apoptotic death].
Topics: Animals; Apoptosis; Cholinesterase Inhibitors; Donepezil; Glioma; HeLa Cells; Humans; Hybrid Cells; | 2002 |
ITH4012 (ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a novel acetylcholinesterase inhibitor with "calcium promotor" and neuroprotective properties.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2004 |
New multipotent tetracyclic tacrines with neuroprotective activity.
Topics: Acetylcholinesterase; Calcium; Cholinesterase Inhibitors; Cytosol; Humans; L-Lactate Dehydrogenase; | 2006 |
Tacrine alters the secretion of the beta-amyloid precursor protein in cell lines.
Topics: Amyloid beta-Protein Precursor; Animals; Cell Differentiation; Cell Line; Cholinesterase Inhibitors; | 1994 |
Potential neurotoxicity of a novel aminoacridine analogue.
Topics: Aminoacridines; Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Explorat | 1995 |
Effects of tacrine upon murine neuroblastoma cells.
Topics: Alzheimer Disease; Animals; Mice; Microscopy, Electron, Scanning; Mitosis; Neuroblastoma; Neurofilam | 1995 |
Differential effect of tacrine and physostigmine on the secretion of the beta-amyloid precursor protein in cell lines.
Topics: Amyloid beta-Protein Precursor; Animals; Arecoline; Astrocytes; Atropine; Calcimycin; Carbachol; Cho | 1996 |
Evaluation of MAO activities on murine neuroblastoma cells upon acute or chronic treatment with aluminium (III) or tacrine.
Topics: Aluminum; Animals; Carbon Radioisotopes; Enzyme Activation; Leucine; Mice; Monoamine Oxidase; Neurob | 1998 |
Responses induced by tacrine in neuronal and non-neuronal cell lines.
Topics: Animals; Cell Differentiation; Cell Size; Dose-Response Relationship, Drug; Glioma; Mice; Neuroblast | 1998 |
The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endope | 1998 |
Tacrine interacts with different sites on nicotinic receptor subtypes in SH-SY5Y neuroblastoma and M10 cells.
Topics: Animals; Cell Line; Humans; Mice; Neuroblastoma; Receptors, Nicotinic; Tacrine; Tumor Cells, Culture | 2000 |
A transient outward current in NG108-15 neuroblastoma x glioma hybrid cells.
Topics: 4-Aminopyridine; Action Potentials; Adrenergic Fibers; Animals; Barium; Calcium; Elapid Venoms; Glio | 1990 |