tacrine has been researched along with Nerve Degeneration in 3 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tacrine was the first acetylcholinesterase inhibitor approved for the treatment of Alzheimer disease." | 3.78 | Tacrine is implicated in oxidative stress in the laboratory guinea pig model. ( Bandouchova, H; Kracmarova, A; Pikula, J; Pohanka, M, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kracmarova, A | 1 |
| Bandouchova, H | 1 |
| Pikula, J | 1 |
| Pohanka, M | 1 |
| Riekkinen, P | 1 |
| Ikonen, S | 1 |
| Aura, J | 1 |
| Riekkinen, M | 1 |
| Xiao, XQ | 1 |
| Lee, NT | 1 |
| Carlier, PR | 1 |
| Pang, Y | 1 |
| Han, YF | 1 |
3 other studies available for tacrine and Nerve Degeneration
| Article | Year |
|---|---|
Tacrine is implicated in oxidative stress in the laboratory guinea pig model.
Topics: Alzheimer Disease; Animals; Antioxidants; Brain; Caspase 3; Chemical and Drug Induced Liver Injury; | 2012 |
Tetrahydroaminoacridine and D-cycloserine fail to alleviate the water maze spatial navigation defect induced by hippocampal inactivation.
Topics: Anesthetics, Local; Animals; Choline O-Acetyltransferase; Cycloserine; Drug Therapy, Combination; Es | 1999 |
Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine.
Topics: Acetylcholine; Alzheimer Disease; Animals; Apoptosis; Cholinesterase Inhibitors; Hydrogen Peroxide; | 2000 |