tacrine has been researched along with Muscle Contraction in 18 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to investigate if tacrine induces reduction of calcium ions through chelation and/or inhibits directly calmodulin's participation in the contractile processes, thus causing smooth muscle relaxation which is not characteristic of a typical acetylcholinesterase blocker." | 3.73 | Effect of tacrine on cytosolic Ca2+ level and calmodulin in gastric muscle tissues of rat. ( Argirova, MD; Krastev, AD; Minkova, EI; Nikolov, RR; Prisadova, NA; Terzieva, D; Turiiski, VI, 2006) |
| "10(-5) mol/l caused smooth muscle contraction, which was blocked by atropine 1." | 3.72 | Influence of tacrine on dopamine-induced reactions of the gastric smooth muscle of rats. ( Getova-Spassova, D; Krustev, A; Spassov, V; Turijski, V, 2004) |
| " There were no consistent pharmacokinetic differences that could explain the effect on intravenous THA on muscle strength in these two patients." | 2.67 | Functional and pharmacokinetic studies of tetrahydroaminoacridine in patients with amyotrophic lateral sclerosis. ( Aquilonius, SM; Askmark, H; Gillberg, PG; Hartvig, P; Hilton-Brown, P; Lindström, B; Nilsson, D; Stålberg, E; Winkler, T, 1990) |
| "Tacrine is a cholinesterase inhibitor used for the treatment of Alzheimer's disease." | 1.33 | Non-anticholinesterase, non-cholinergic effect of tacrine on gastrointestinal smooth muscle tissues of rat. ( Argirova, MD; Krustev, AD; Turiiski, VI, 2005) |
| "Tacrine (THA) is an anticholinesterase drug used to manage Alzheimer's dementia, but it is not clear how its chronic use might affect response to nondepolarizing muscle relaxants." | 1.30 | The effects of chronic tacrine therapy on d-tubocurarine blockade in the soleus and tibialis muscles of the rat. ( Donati, F; Eshelby, D; Fox, GS; Ibebunjo, C; Tchervenkov, JI, 1997) |
| "Tacrine is a cholinesterase inhibitor used to manage Alzheimer's dementia." | 1.30 | Tacrine does not alter the potency of succinylcholine in the rat. ( Donati, F; Eshelby, D; Fox, GS; Ibebunjo, C; Tchervenkov, JI, 1997) |
| "3." | 1.29 | Comparative effects of velnacrine, tacrine and physostigmine on the twitch responses in the rat phrenic-hemidiaphragm preparation. ( Badia, A; Baños, JE; Bosch, F; Morales, M, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 8 (44.44) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Valli, MJ | 1 |
| Tang, Y | 1 |
| Kosh, JW | 1 |
| Chapman, JM | 1 |
| Sowell, JW | 1 |
| Camps, P | 1 |
| El Achab, R | 1 |
| Görbig, DM | 1 |
| Morral, J | 1 |
| Muñoz-Torrero, D | 1 |
| Badia, A | 3 |
| Eladi Baños, J | 1 |
| Vivas, NM | 1 |
| Barril, X | 1 |
| Orozco, M | 1 |
| Luque, FJ | 1 |
| Pereira, JD | 1 |
| Caricati-Neto, A | 2 |
| Miranda-Ferreira, R | 1 |
| Smaili, SS | 1 |
| Godinho, RO | 1 |
| de los Rios, C | 2 |
| Léon, R | 1 |
| Villaroya, M | 1 |
| Samadi, A | 1 |
| Marco-Contelles, J | 1 |
| Jurkiewicz, NH | 1 |
| Garcia, AG | 3 |
| Jurkiewicz, A | 2 |
| Turijski, V | 1 |
| Krustev, A | 2 |
| Getova-Spassova, D | 1 |
| Spassov, V | 1 |
| D'angelo, LC | 1 |
| Reuter, H | 1 |
| Hyppolito Jurkiewicz, N | 1 |
| Turiiski, VI | 3 |
| Argirova, MD | 3 |
| Krustev, AD | 2 |
| Getova, DP | 1 |
| Prissadova, NA | 1 |
| Prisadova, NA | 1 |
| Minkova, EI | 1 |
| Nikolov, RR | 1 |
| Terzieva, D | 1 |
| Krastev, AD | 1 |
| Sirakov, V | 1 |
| Turiiski, V | 1 |
| Getova, D | 1 |
| Velkova, K | 1 |
| Prissadova, N | 1 |
| Bosch, F | 2 |
| Morales, M | 2 |
| Baños, JE | 2 |
| Biyah, K | 1 |
| Molimard, M | 1 |
| Naline, E | 1 |
| Bazelly, B | 1 |
| Advenier, C | 1 |
| Ibebunjo, C | 2 |
| Donati, F | 2 |
| Fox, GS | 2 |
| Eshelby, D | 2 |
| Tchervenkov, JI | 2 |
| Becerra, MA | 1 |
| Herrera, MD | 1 |
| Marhuenda, E | 1 |
| Marco, JL | 1 |
| Carreiras, MD | 1 |
| Chinchón, PM | 1 |
| Villarroya, M | 1 |
| Wong, CL | 1 |
| Bentley, GA | 1 |
| Askmark, H | 1 |
| Aquilonius, SM | 1 |
| Gillberg, PG | 1 |
| Hartvig, P | 1 |
| Hilton-Brown, P | 1 |
| Lindström, B | 1 |
| Nilsson, D | 1 |
| Stålberg, E | 1 |
| Winkler, T | 1 |
1 trial available for tacrine and Muscle Contraction
| Article | Year |
|---|---|
Functional and pharmacokinetic studies of tetrahydroaminoacridine in patients with amyotrophic lateral sclerosis.
Topics: Administration, Oral; Adult; Aged; Amyotrophic Lateral Sclerosis; Drug Therapy, Combination; Electro | 1990 |
17 other studies available for tacrine and Muscle Contraction
| Article | Year |
|---|---|
Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine.
Topics: Acetylcholine; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Synergism; Ery | 1992 |
Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alkaloids; Animals; Binding Sites; Cholinesterase Inhibitors; Diaphragm; In Vi | 1999 |
Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity.
Topics: Acetylcholine; Acetylcholinesterase; Adenosine Triphosphate; Animals; Butyrylcholinesterase; Calcium | 2011 |
Influence of tacrine on dopamine-induced reactions of the gastric smooth muscle of rats.
Topics: Animals; Atropine; Dopamine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Dru | 2004 |
Enhancement of purinergic neurotransmission by galantamine and other acetylcholinesterase inhibitors in the rat vas deferens.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Donepezil; Drug Synergism; | 2004 |
Non-anticholinesterase, non-cholinergic effect of tacrine on gastrointestinal smooth muscle tissues of rat.
Topics: Analysis of Variance; Animals; Cholinesterase Inhibitors; Gastrointestinal Tract; Male; Muscle Contr | 2005 |
Calcium-independent tacrine-induced relaxation of rat gastric corpus smooth muscles.
Topics: Acetylcholine; Animals; Caffeine; Calcium; Calcium Channel Blockers; Cholinergic Antagonists; Cholin | 2006 |
Effect of tacrine on cytosolic Ca2+ level and calmodulin in gastric muscle tissues of rat.
Topics: Animals; Calcium; Calmodulin; Chelating Agents; Cholinesterase Inhibitors; Cytosol; Dose-Response Re | 2006 |
Delayed evacuatory function due to specific smooth muscle reactivity in the gastrointestinal tracts of tacrine-treated rats.
Topics: Animals; Gastrointestinal Tract; Gastrointestinal Transit; Male; Muscle Contraction; Muscle, Smooth; | 2008 |
Comparative effects of velnacrine, tacrine and physostigmine on the twitch responses in the rat phrenic-hemidiaphragm preparation.
Topics: Animals; Cholinesterase Inhibitors; Electric Stimulation; In Vitro Techniques; Male; Muscle Contract | 1993 |
Indirect muscarinic receptor activation by pentamidine on airway smooth muscle.
Topics: Adult; Aged; Animals; Bronchi; Female; Guinea Pigs; Humans; Male; Middle Aged; Morphine; Muscle Cont | 1996 |
The effects of chronic tacrine therapy on d-tubocurarine blockade in the soleus and tibialis muscles of the rat.
Topics: Administration, Oral; Alzheimer Disease; Anesthesia, General; Animals; Cholinesterase Inhibitors; Do | 1997 |
Tacrine does not alter the potency of succinylcholine in the rat.
Topics: Administration, Oral; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Dose-Response Relations | 1997 |
Action of tacrine on muscarinic receptors in rat intestinal smooth muscle.
Topics: Acetylcholine; Animals; Carbachol; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Duod | 2001 |
Novel tacrine derivatives that block neuronal calcium channels.
Topics: Animals; Aorta; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cattle; Chro | 2002 |
The effect of stress and adrenalectomy on morphine analgesia and naloxone potency in mice.
Topics: Adrenal Medulla; Adrenalectomy; Analgesia; Animals; Atropine; Corticosterone; Male; Mice; Morphine; | 1979 |
Effects of velnacrine, tacrine and physostigmine on tetanic twitch responses at the rat neuromuscular junction.
Topics: Animals; Cholinesterase Inhibitors; Diaphragm; Electric Stimulation; In Vitro Techniques; Male; Musc | 1992 |