tacrine has been researched along with Idiopathic Parkinson Disease in 14 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of adenosine A(2A) receptor antagonists were here assessed in a rat model of parkinsonian tremor induced by cholinomimetic drugs by evaluating the counteraction of tremulous jaw movements." | 3.73 | Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease. ( Baraldi, PG; Fenu, S; Morelli, M; Simola, N; Tabrizi, MA, 2006) |
| "A patient with Alzheimer's disease and mild features of parkinsonism was treated with tacrine." | 1.28 | Exacerbation of parkinsonism by tacrine. ( Lannon, MC; Ott, BR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (64.29) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalli, A | 1 |
| Bolognesi, ML | 1 |
| Minarini, A | 1 |
| Rosini, M | 1 |
| Tumiatti, V | 1 |
| Recanatini, M | 1 |
| Melchiorre, C | 1 |
| Mohamed, T | 1 |
| Yeung, JC | 1 |
| Rao, PP | 1 |
| Kasture, S | 1 |
| Pontis, S | 1 |
| Pinna, A | 1 |
| Schintu, N | 1 |
| Spina, L | 1 |
| Longoni, R | 1 |
| Simola, N | 2 |
| Ballero, M | 1 |
| Morelli, M | 2 |
| Ringman, JM | 1 |
| Cummings, JL | 2 |
| Fenu, S | 1 |
| Baraldi, PG | 1 |
| Tabrizi, MA | 1 |
| Perry, EK | 1 |
| Haroutunian, V | 1 |
| Davis, KL | 1 |
| Levy, R | 2 |
| Lantos, P | 1 |
| Eagger, S | 1 |
| Honavar, M | 1 |
| Dean, A | 1 |
| Griffiths, M | 1 |
| McKeith, IG | 1 |
| Hutchinson, M | 1 |
| Fazzini, E | 1 |
| Gidal, BE | 1 |
| Crismon, ML | 1 |
| Wagner, ML | 1 |
| Fagan, SC | 1 |
| Privitera, MD | 1 |
| Dalmady-Israel, C | 1 |
| Graves, NM | 1 |
| Mayorga, AJ | 1 |
| Carriero, DL | 1 |
| Cousins, MS | 1 |
| Gianutsos, G | 1 |
| Salamone, JD | 1 |
| Scarbrough, TJ | 1 |
| Maloteaux, JM | 1 |
| Ott, BR | 1 |
| Lannon, MC | 1 |
5 reviews available for tacrine and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Multi-target-directed ligands to combat neurodegenerative diseases.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Binding Sites; Calcium | 2008 |
Current and emerging pharmacological treatment options for dementia.
Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Human | 2006 |
Dementia: the failing brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dementia; Dementia, Vascular; Humans; Middle Aged; Parki | 1995 |
Current developments in neurology, Part II: Advances in the pharmacotherapy of Alzheimer disease, Parkinson's disease, and stroke.
Topics: Alzheimer Disease; Anticoagulants; Apomorphine; Aspirin; Cerebrovascular Disorders; Cholinergic Agen | 1996 |
Diffuse Lewy body disease: a common yet misdiagnosed dementia in which neuroleptics may be contraindicated.
Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Brain; Cholinesterase Inhibitors; Contraindications; | 1998 |
2 trials available for tacrine and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Neocortical cholinergic activities differentiate Lewy body dementia from classical Alzheimer's disease.
Topics: Alzheimer Disease; Cerebral Cortex; Choline O-Acetyltransferase; Diagnosis, Differential; Humans; Pa | 1994 |
Cholinesterase inhibition in Parkinson's disease.
Topics: Aged; Cholinesterase Inhibitors; Dementia; Female; Humans; Male; Parkinson Disease; Pilot Projects; | 1996 |
7 other studies available for tacrine and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzhydryl Compounds; Butyrylcholinesterase; Cholineste | 2011 |
Assessment of symptomatic and neuroprotective efficacy of Mucuna pruriens seed extract in rodent model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Antiparkinson Agents; C | 2009 |
Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease.
Topics: Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Rela | 2006 |
Alzheimer's disease and Lewy body dementia.
Topics: Alzheimer Disease; Brain; Diagnosis, Differential; Humans; Lewy Bodies; Parkinson Disease; Tacrine | 1994 |
Tremulous jaw movements produced by acute tacrine administration: possible relation to parkinsonian side effects.
Topics: Animals; Corpus Striatum; Dose-Response Relationship, Drug; Jaw; Male; Muscarinic Antagonists; Paras | 1997 |
[Clinical pharmacology and therapeutic aspects in certain degenerative neurological diseases].
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Antiparkinson Agents; Cholinesterase Inhibitors; H | 1996 |
Exacerbation of parkinsonism by tacrine.
Topics: Aged; Alzheimer Disease; Electromyography; Female; Humans; Levodopa; Parkinson Disease; Tacrine | 1992 |