tacrine has been researched along with Hypothermia, Accidental in 5 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The non-selective muscarinic agonists pilocarpine, oxotremorine, RS-86, S-aceclidine, but not the less active isomer R-aceclidine, also effectively stimulated PI hydrolysis in mice." | 3.70 | Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects. ( Bymaster, FP; Calligaro, DO; Carter, PA; DeLapp, N; Fink-Jensen, A; Jeppesen, L; Mitch, CH; Peters, SC; Rimvall, K; Sauerberg, P; Shannon, HE; Sheardown, MJ; Ward, JS; Whitesitt, CA; Zhang, W, 1998) |
| " The present study investigated the dose-response characteristics of donepezil, tacrine, rivastigmine and metrifonate in inducing tremor, lacrimation, salivation and hypothermia and the duration of action of these compounds in Lister hooded rats." | 3.70 | Comparison of donepezil-, tacrine-, rivastigmine- and metrifonate-induced central and peripheral cholinergically mediated responses in the rat. ( Dronfield, S; Egan, K; Green, AR; Marsden, CA, 2000) |
| "Tacrine disposition was maintained with age, and area under the concentration-time curve and clearance in old rats were similar to those in young rats for all drugs tested as was bioavailability." | 1.37 | Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. ( Aw, CC; Browne, ER; Chen, CP; Goh, CW; Lee, JH, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goh, CW | 1 |
| Aw, CC | 1 |
| Lee, JH | 1 |
| Chen, CP | 1 |
| Browne, ER | 1 |
| Patel, S | 1 |
| Hutson, PH | 1 |
| Bymaster, FP | 1 |
| Carter, PA | 1 |
| Peters, SC | 1 |
| Zhang, W | 1 |
| Ward, JS | 1 |
| Mitch, CH | 1 |
| Calligaro, DO | 1 |
| Whitesitt, CA | 1 |
| DeLapp, N | 1 |
| Shannon, HE | 1 |
| Rimvall, K | 1 |
| Jeppesen, L | 1 |
| Sheardown, MJ | 1 |
| Fink-Jensen, A | 1 |
| Sauerberg, P | 1 |
| Dronfield, S | 1 |
| Egan, K | 1 |
| Marsden, CA | 1 |
| Green, AR | 1 |
| Wang, RH | 1 |
| Weinstock, M | 1 |
5 other studies available for tacrine and Hypothermia, Accidental
| Article | Year |
|---|---|
Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats.
Topics: Aging; Animals; Biological Availability; Brain; Cholinesterase Inhibitors; Cholinesterases; Donepezi | 2011 |
Hypothermia induced by cholinomimetic drugs is blocked by galanin: possible involvement of ATP-sensitive K+ channels.
Topics: Adenosine Triphosphate; Animals; Cerebral Cortex; Galanin; Glyburide; Hypoglycemic Agents; Hypotherm | 1994 |
Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects.
Topics: Animals; Binding, Competitive; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic | 1998 |
Comparison of donepezil-, tacrine-, rivastigmine- and metrifonate-induced central and peripheral cholinergically mediated responses in the rat.
Topics: Animals; Body Temperature; Carbamates; Cholinesterase Inhibitors; Donepezil; Dose-Response Relations | 2000 |
Steroid hormones mediate sex difference in brain levels of tacrine and its hypothermic effect in the rat.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents; Body Temperature Regulation; Brain; Cholinesterase | 2001 |