tacrine has been researched along with Genetic Predisposition in 2 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this retrospective analysis of 443 Alzheimer disease (AD) patients from a 30-week tacrine trial, change in Alzheimer's Disease Assessment Scale score from baseline to final value was significantly associated with a total serum cholesterol/APOE genotype interaction." | 5.11 | Cholesterol and APOE genotype interact to influence Alzheimer disease progression. ( Evans, RM; Farlow, MR; Hui, S; Lahiri, DK; Perkins, A; Poirier, J, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Evans, RM | 1 |
| Hui, S | 1 |
| Perkins, A | 1 |
| Lahiri, DK | 1 |
| Poirier, J | 1 |
| Farlow, MR | 1 |
| Simon, T | 1 |
| Becquemont, L | 1 |
| Mary-Krause, M | 1 |
| de Waziers, I | 1 |
| Beaune, P | 1 |
| Funck-Brentano, C | 1 |
| Jaillon, P | 1 |
2 trials available for tacrine and Genetic Predisposition
| Article | Year |
|---|---|
Cholesterol and APOE genotype interact to influence Alzheimer disease progression.
Topics: Aged; Alzheimer Disease; Apolipoprotein E4; Apolipoproteins E; Cholesterol; Disease Progression; Dou | 2004 |
Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity.
Topics: Aged; Alleles; Alzheimer Disease; Female; Genetic Predisposition to Disease; Genotype; Glutathione T | 2000 |