tacrine has been researched along with Disease Models, Animal in 58 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we tested the effects of a synthesized juxtaposition (named SCR1693) composed of an acetylcholinesterase inhibitor (AChEI) and a calcium channel blocker (CCB) on the hyperhomocysteinemia (HHcy)-induced AD rat model, and found that SCR1693 remarkably improved the HHcy-induced memory deficits and preserved dendrite morphologies as well as spine density by upregulating synapse-associated proteins PSD95 and synapsin-1." | 7.80 | Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats. ( Chen, R; Hu, J; Liu, R; Liu, X; Tian, Q; Wang, JZ; Wang, P; Wang, Q; Wang, XC; Xia, Y; Zeng, K, 2014) |
| "To examine the mechanisms underlying the anti-tremor effect of zonisamide in rats under conditions of tacrine-induced tremulous jaw movements (TJMs)." | 7.75 | Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect. ( Kondo, T; Kubo, T; Miwa, H; Suzuki, A, 2009) |
| " Therefore, the present study was designed to investigate the influence of antidementia drugs, tacrine and donepezil, on biochemical markers of oxidative stress, glutathione (GSH) and malondialdehyde (MDA), and acetylcholinesterase activity in the brain in a streptozotocin-induced experimental model of dementia in mice." | 7.74 | Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice. ( Agrawal, R; Nath, C; Saxena, G; Singh, SP, 2008) |
| "Retinal ischemia was induced by raising the intraocular pressure to 120 mmHg for 90 min." | 5.40 | Neuroprotective effects of bis(7)-tacrine in a rat model of pressure-induced retinal ischemia. ( Fang, JH; Li, JB; Lu, ZG; Wang, Q; Xu, L; Zhang, ZH, 2014) |
| " In this study, we tested the effects of a synthesized juxtaposition (named SCR1693) composed of an acetylcholinesterase inhibitor (AChEI) and a calcium channel blocker (CCB) on the hyperhomocysteinemia (HHcy)-induced AD rat model, and found that SCR1693 remarkably improved the HHcy-induced memory deficits and preserved dendrite morphologies as well as spine density by upregulating synapse-associated proteins PSD95 and synapsin-1." | 3.80 | Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats. ( Chen, R; Hu, J; Liu, R; Liu, X; Tian, Q; Wang, JZ; Wang, P; Wang, Q; Wang, XC; Xia, Y; Zeng, K, 2014) |
| "Tacrine was the first acetylcholinesterase inhibitor approved for the treatment of Alzheimer disease." | 3.78 | Tacrine is implicated in oxidative stress in the laboratory guinea pig model. ( Bandouchova, H; Kracmarova, A; Pikula, J; Pohanka, M, 2012) |
| "To examine the mechanisms underlying the anti-tremor effect of zonisamide in rats under conditions of tacrine-induced tremulous jaw movements (TJMs)." | 3.75 | Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect. ( Kondo, T; Kubo, T; Miwa, H; Suzuki, A, 2009) |
| " Therefore, the present study was designed to investigate the influence of antidementia drugs, tacrine and donepezil, on biochemical markers of oxidative stress, glutathione (GSH) and malondialdehyde (MDA), and acetylcholinesterase activity in the brain in a streptozotocin-induced experimental model of dementia in mice." | 3.74 | Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice. ( Agrawal, R; Nath, C; Saxena, G; Singh, SP, 2008) |
| " The effects of adenosine A(2A) receptor antagonists were here assessed in a rat model of parkinsonian tremor induced by cholinomimetic drugs by evaluating the counteraction of tremulous jaw movements." | 3.73 | Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease. ( Baraldi, PG; Fenu, S; Morelli, M; Simola, N; Tabrizi, MA, 2006) |
| "Rosmarinic acid (RA) is a natural compound of phenolic acids that has pharmacological activity for inhibiting Alzheimer's disease, as well as liver protection." | 1.91 | Rosmarinic acid potentiates and detoxifies tacrine in combination for Alzheimer's disease. ( Gao, W; Guo, L; Han, X; Huang, L; Ji, H; Li, X; Qiao, O; Wang, J; Wang, W; Yang, M; Zhang, X; Zhang, Y, 2023) |
| "Huperzine A (HupA) is a kind of Lycopodium alkaloid with potential disease-modifying qualities that has been reported to protect against β-amyloid (Aβ)-mediated mitochondrial damage in Alzheimer's disease." | 1.51 | ABAD/17β-HSD10 reduction contributes to the protective mechanism of huperzine a on the cerebral mitochondrial function in APP/PS1 mice. ( Chen, Q; Wang, Y; Xiao, X; Zhu, X, 2019) |
| "Also, reduction of amyloid plaque burden and gliosis in the cortex and hippocampus was assessed." | 1.46 | The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease. ( Fernandez, AP; Futch, HS; Herrero-Labrador, R; Marco-Contelles, J; Martínez-Murillo, R; Romero, A; Samadi, A; Serrano, J; Serrano, MP; Unzeta, M, 2017) |
| "Due to the complex nature of Alzheimer's disease, multi-target-directed ligand approaches are one of the most promising strategies in the search for effective treatments." | 1.42 | Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo. ( Bajda, M; Brus, B; Czerwińska, P; Filipek, B; Gobec, S; Malawska, B; Sałat, K; Więckowska, A; Więckowski, K, 2015) |
| "Retinal ischemia was induced by raising the intraocular pressure to 120 mmHg for 90 min." | 1.40 | Neuroprotective effects of bis(7)-tacrine in a rat model of pressure-induced retinal ischemia. ( Fang, JH; Li, JB; Lu, ZG; Wang, Q; Xu, L; Zhang, ZH, 2014) |
| "Tacrine is an acetylcholinesterase (AChE) inhibitor used as a cognitive enhancer in the treatment of Alzheimer's disease (AD)." | 1.38 | Tacrine and its analogues impair mitochondrial function and bioenergetics: a lipidomic analysis in rat brain. ( André, S; Domingues, MR; Francisco, CS; Maciel, E; Manuel Oliveira, M; Melo, T; Oliveira-Campos, AM; Peixoto, F; Rodrigues, LM; Videira, RA, 2012) |
| "The toxic effect of THA on mice liver was significantly reduced by DDB." | 1.31 | [Effect of dimethyl diphenyl bicarboxylate (DDB) on 9-amino-1,2,3,4-tetrahydroacridine-induced hepatotoxicity in mice]. ( Li, Y, 2001) |
| " Its long duration of action, coupled with its short pharmacokinetic half-life, reduces dosing frequency, decreases body drug exposure and minimizes the dependence of drug action on the individual variations of drug metabolism commonly found in the elderly." | 1.31 | The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics. ( Brossi, A; De Micheli, E; Deutsch, J; Greig, NH; Holloway, HW; Ingram, DK; Lahiri, DK; Perry, TA; Soncrant, TT; Utsuki, T; Yu, QS, 2000) |
| "Tacrine was found to biphasically both increase (10(-6) and 5 x 10(-6) M) and decrease (10(-5)-10(-4) M) the release of ACh in a concentration-dependent manner." | 1.29 | Biphasic effect of tacrine on acetylcholine release in rat brain via M1 and M2 receptors. ( Nordberg, A; Svensson, AL; Zhang, X, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.72) | 18.7374 |
| 1990's | 6 (10.34) | 18.2507 |
| 2000's | 18 (31.03) | 29.6817 |
| 2010's | 27 (46.55) | 24.3611 |
| 2020's | 6 (10.34) | 2.80 |
| Authors | Studies |
|---|---|
| Więckowska, A | 1 |
| Więckowski, K | 1 |
| Bajda, M | 1 |
| Brus, B | 1 |
| Sałat, K | 1 |
| Czerwińska, P | 1 |
| Gobec, S | 1 |
| Filipek, B | 1 |
| Malawska, B | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Jiang, X | 1 |
| Guo, J | 1 |
| Lv, Y | 1 |
| Yao, C | 1 |
| Zhang, C | 1 |
| Mi, Z | 1 |
| Shi, Y | 1 |
| Gu, J | 1 |
| Zhou, T | 1 |
| Bai, R | 1 |
| Xie, Y | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 3 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Li, Q | 1 |
| Chen, Y | 2 |
| Xing, S | 1 |
| Liao, Q | 1 |
| Xiong, B | 1 |
| Wang, Y | 2 |
| Lu, W | 1 |
| He, S | 1 |
| Feng, F | 1 |
| Liu, W | 1 |
| Sun, H | 1 |
| Yang, M | 1 |
| Zhang, X | 3 |
| Qiao, O | 1 |
| Ji, H | 1 |
| Zhang, Y | 2 |
| Han, X | 1 |
| Wang, W | 1 |
| Li, X | 1 |
| Wang, J | 1 |
| Guo, L | 1 |
| Huang, L | 2 |
| Gao, W | 1 |
| Zuo, X | 1 |
| Hu, S | 2 |
| Tang, Y | 1 |
| Zhan, L | 1 |
| Sun, W | 1 |
| Zheng, J | 1 |
| Han, Y | 5 |
| Xu, E | 1 |
| Kim, S | 1 |
| Lee, DW | 1 |
| Schachner, M | 1 |
| Park, HC | 1 |
| Yip, LY | 1 |
| Aw, CC | 1 |
| Lee, SH | 1 |
| Hong, YS | 1 |
| Ku, HC | 1 |
| Xu, WH | 1 |
| Chan, JMX | 1 |
| Cheong, EJY | 1 |
| Chng, KR | 1 |
| Ng, AHQ | 1 |
| Nagarajan, N | 1 |
| Mahendran, R | 1 |
| Lee, YK | 1 |
| Browne, ER | 1 |
| Chan, ECY | 1 |
| Chen, H | 1 |
| Xiang, S | 1 |
| Lin, J | 1 |
| Mak, SH | 2 |
| Wang, C | 1 |
| Wang, Q | 3 |
| Cui, W | 2 |
| Xiao, X | 1 |
| Chen, Q | 1 |
| Zhu, X | 1 |
| Ishola, IO | 2 |
| Tota, S | 2 |
| Adeyemi, OO | 2 |
| Agbaje, EO | 2 |
| Narender, T | 1 |
| Shukla, R | 2 |
| Li, JB | 1 |
| Lu, ZG | 1 |
| Xu, L | 1 |
| Zhang, ZH | 1 |
| Fang, JH | 1 |
| Pinna, A | 2 |
| Bonaventura, J | 1 |
| Farré, D | 1 |
| Sánchez, M | 1 |
| Simola, N | 4 |
| Mallol, J | 1 |
| Lluís, C | 1 |
| Costa, G | 1 |
| Baqi, Y | 1 |
| Müller, CE | 1 |
| Cortés, A | 1 |
| McCormick, P | 1 |
| Canela, EI | 1 |
| Martínez-Pinilla, E | 1 |
| Lanciego, JL | 1 |
| Casadó, V | 1 |
| Armentero, MT | 1 |
| Franco, R | 1 |
| Xia, Y | 1 |
| Liu, R | 1 |
| Chen, R | 1 |
| Tian, Q | 1 |
| Zeng, K | 1 |
| Hu, J | 1 |
| Liu, X | 1 |
| Wang, P | 2 |
| Wang, XC | 1 |
| Wang, JZ | 1 |
| Choi, JS | 1 |
| Han, YR | 1 |
| Byeon, JS | 1 |
| Choung, SY | 1 |
| Sohn, HS | 1 |
| Jung, HA | 1 |
| Lee, JS | 1 |
| Kim, HG | 1 |
| Lee, HW | 1 |
| Han, JM | 1 |
| Lee, SK | 1 |
| Kim, DW | 1 |
| Saravanakumar, A | 1 |
| Son, CG | 1 |
| Arunrungvichian, K | 1 |
| Boonyarat, C | 1 |
| Fokin, VV | 1 |
| Taylor, P | 1 |
| Vajragupta, O | 1 |
| Hu, SQ | 2 |
| Wang, R | 2 |
| Li, G | 1 |
| Hu, YJ | 1 |
| Lee, MY | 1 |
| Pang, YP | 1 |
| Han, YF | 3 |
| Liu, JM | 1 |
| Wu, PF | 1 |
| Rao, J | 1 |
| Zhou, J | 1 |
| Shen, ZC | 1 |
| Luo, H | 1 |
| Huang, JG | 1 |
| Liang, X | 1 |
| Long, LH | 1 |
| Xie, QG | 1 |
| Jiang, FC | 1 |
| Wang, F | 1 |
| Chen, JG | 1 |
| Serrano, MP | 1 |
| Herrero-Labrador, R | 1 |
| Futch, HS | 1 |
| Serrano, J | 1 |
| Romero, A | 1 |
| Fernandez, AP | 1 |
| Samadi, A | 1 |
| Unzeta, M | 1 |
| Marco-Contelles, J | 1 |
| Martínez-Murillo, R | 1 |
| Zhao, Y | 1 |
| Chow, PC | 1 |
| Lau, DT | 1 |
| Lee, NT | 1 |
| Pang, Y | 1 |
| Wang, X | 1 |
| Hu, Y | 1 |
| Wang, Z | 1 |
| Zhang, R | 1 |
| Wu, P | 1 |
| Xia, Z | 1 |
| Orsi, A | 1 |
| Rees, D | 1 |
| Miwa, H | 1 |
| Kubo, T | 1 |
| Suzuki, A | 1 |
| Kondo, T | 1 |
| Kasture, S | 1 |
| Pontis, S | 1 |
| Schintu, N | 1 |
| Spina, L | 1 |
| Longoni, R | 1 |
| Ballero, M | 1 |
| Morelli, M | 3 |
| Trevitt, J | 1 |
| Kawa, K | 1 |
| Jalali, A | 1 |
| Larsen, C | 1 |
| Spuch, C | 1 |
| Antequera, D | 1 |
| Isabel Fernandez-Bachiller, M | 1 |
| Isabel Rodríguez-Franco, M | 1 |
| Carro, E | 1 |
| Iannone, M | 1 |
| Cosco, D | 1 |
| Cilurzo, F | 1 |
| Celia, C | 1 |
| Paolino, D | 1 |
| Mollace, V | 1 |
| Rotiroti, D | 1 |
| Fresta, M | 1 |
| Roland, JJ | 1 |
| Levinson, M | 1 |
| Vetreno, RP | 1 |
| Savage, LM | 1 |
| Pan, SY | 1 |
| Guo, BF | 1 |
| Ko, KM | 1 |
| Saxena, G | 2 |
| Patro, IK | 1 |
| Nath, C | 2 |
| Kim, DH | 2 |
| Park, SJ | 1 |
| Kim, JM | 1 |
| Jeon, SJ | 1 |
| Cho, YW | 1 |
| Son, KH | 1 |
| Lee, HJ | 1 |
| Moon, JH | 1 |
| Cheong, JH | 1 |
| Ko, KH | 1 |
| Ryu, JH | 1 |
| Melo, T | 1 |
| Videira, RA | 1 |
| André, S | 1 |
| Maciel, E | 1 |
| Francisco, CS | 1 |
| Oliveira-Campos, AM | 1 |
| Rodrigues, LM | 1 |
| Domingues, MR | 1 |
| Peixoto, F | 1 |
| Manuel Oliveira, M | 1 |
| Pi, R | 1 |
| Mao, X | 1 |
| Chao, X | 1 |
| Cheng, Z | 1 |
| Liu, M | 1 |
| Duan, X | 1 |
| Ye, M | 1 |
| Chen, X | 1 |
| Mei, Z | 1 |
| Liu, P | 1 |
| Han, RW | 1 |
| Zhang, RS | 1 |
| Chang, M | 1 |
| Peng, YL | 1 |
| Choi, CL | 1 |
| Yin, M | 1 |
| Kracmarova, A | 1 |
| Bandouchova, H | 1 |
| Pikula, J | 1 |
| Pohanka, M | 1 |
| Carlson, BB | 2 |
| Wisniecki, A | 2 |
| Salamone, JD | 2 |
| Li, Y | 2 |
| Fenu, S | 2 |
| Baraldi, PG | 2 |
| Tabrizi, MA | 2 |
| Getova, DP | 1 |
| Dimitrova, DS | 1 |
| Rios, C | 1 |
| Lentini, E | 1 |
| Correa, M | 1 |
| Betz, A | 1 |
| Jordá, EG | 1 |
| Verdaguer, E | 1 |
| Jiménez, A | 1 |
| Canudas, AM | 1 |
| Rimbau, V | 1 |
| Camps, P | 1 |
| Muñoz-Torrero, D | 1 |
| Camins, A | 1 |
| Pallàs, M | 1 |
| Terranova, JP | 1 |
| Chabot, C | 1 |
| Barnouin, MC | 1 |
| Perrault, G | 1 |
| Depoortere, R | 1 |
| Griebel, G | 1 |
| Scatton, B | 1 |
| Xu, Z | 1 |
| Zheng, H | 1 |
| Law, SL | 1 |
| Dong So, D | 1 |
| Xue, H | 1 |
| Singh, SP | 1 |
| Agrawal, R | 1 |
| Tribouillard-Tanvier, D | 1 |
| Béringue, V | 1 |
| Desban, N | 1 |
| Gug, F | 1 |
| Bach, S | 1 |
| Voisset, C | 1 |
| Galons, H | 1 |
| Laude, H | 1 |
| Vilette, D | 1 |
| Blondel, M | 1 |
| Burov, IuV | 1 |
| Baĭmanov, TD | 1 |
| Robakidze, TN | 1 |
| Miyamoto, M | 1 |
| Takahashi, H | 1 |
| Kato, K | 1 |
| Hirai, K | 1 |
| Ishihara, Y | 1 |
| Goto, G | 1 |
| Svensson, AL | 1 |
| Nordberg, A | 1 |
| Murakami, Y | 2 |
| Tanaka, E | 1 |
| Sakai, Y | 1 |
| Matsumoto, K | 2 |
| Li, HB | 1 |
| Watanabe, H | 2 |
| Ikenoya, M | 1 |
| Li, H | 1 |
| Lermontova, NN | 1 |
| Lukoyanov, NV | 1 |
| Serkova, TP | 1 |
| Lukoyanova, EA | 1 |
| Bachurin, SO | 1 |
| Greig, NH | 1 |
| De Micheli, E | 1 |
| Holloway, HW | 1 |
| Yu, QS | 1 |
| Utsuki, T | 1 |
| Perry, TA | 1 |
| Brossi, A | 1 |
| Ingram, DK | 1 |
| Deutsch, J | 1 |
| Lahiri, DK | 1 |
| Soncrant, TT | 1 |
| Ueki, A | 2 |
| Miyoshi, K | 1 |
| Kwo-On-Yuen, PF | 1 |
| Mandel, R | 1 |
| Chen, AD | 1 |
| Thal, LJ | 1 |
| Taira, H | 1 |
| Miyoshi, I | 1 |
58 other studies available for tacrine and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.
Topics: Acetylcholinesterase; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Blood-Brain Barrie | 2015 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Behavior, Animal; Binding Sites; Ce | 2020 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection.
Topics: Amyloid beta-Peptides; Animals; Binding Sites; Butyrylcholinesterase; Cell Survival; Cholinesterase | 2021 |
Rosmarinic acid potentiates and detoxifies tacrine in combination for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Chemical and Drug Induced L | 2023 |
Attenuation of secondary damage and Aβ deposits in the ipsilateral thalamus of dMCAO rats through reduction of cathepsin B by bis(propyl)-cognitin, a multifunctional dimer.
Topics: Amyloid beta-Peptides; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antigens, N | 2020 |
Small compounds mimicking the adhesion molecule L1 improve recovery in a zebrafish demyelination model.
Topics: Animals; Cell Differentiation; Demyelinating Diseases; Disease Models, Animal; Duloxetine Hydrochlor | 2021 |
The liver-gut microbiota axis modulates hepatotoxicity of tacrine in the rat.
Topics: Animals; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Respon | 2018 |
Tacrine(10)-hupyridone, a dual-binding acetylcholinesterase inhibitor, potently attenuates scopolamine-induced impairments of cognition in mice.
Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Cognitive Dysfunction; Disease Models, Animal; | 2018 |
ABAD/17β-HSD10 reduction contributes to the protective mechanism of huperzine a on the cerebral mitochondrial function in APP/PS1 mice.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brai | 2019 |
Protective effect of Cnestis ferruginea and its active constituent on scopolamine-induced memory impairment in mice: a behavioral and biochemical study.
Topics: Acetylcholinesterase; Administration, Oral; Animals; Antioxidants; Avoidance Learning; Biflavonoids; | 2013 |
Neuroprotective effects of bis(7)-tacrine in a rat model of pressure-induced retinal ischemia.
Topics: Animals; Disease Models, Animal; Electroretinography; Ischemia; Male; Neuroprotective Agents; Pressu | 2014 |
L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Cannabinoid Receptor Antagonists; | 2014 |
Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats.
Topics: Animals; Brain Diseases; Calcium Channel Blockers; Cholinesterase Inhibitors; Disease Models, Animal | 2014 |
Protective effect of fucosterol isolated from the edible brown algae, Ecklonia stolonifera and Eisenia bicyclis, on tert-butyl hydroperoxide- and tacrine-induced HepG2 cell injury.
Topics: Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Respons | 2015 |
Hippocampal memory enhancing activity of pine needle extract against scopolamine-induced amnesia in a mouse model.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Cell Prolif | 2015 |
Cognitive improvements in a mouse model with substituted 1,2,3-triazole agonists for nicotinic acetylcholine receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; Cholinester | 2015 |
Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's β-Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Cell Survival; Disease | 2015 |
ST09, a Novel Thioester Derivative of Tacrine, Alleviates Cognitive Deficits and Enhances Glucose Metabolism in Vascular Dementia Rats.
Topics: Acetylcholinesterase; Animals; Apoptosis; Cell Line, Transformed; Cerebral Cortex; Cognition Disorde | 2016 |
The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Animals; Cell Survival; Cerebral Cortex; Disease Models, Animal; Donepezil; Glios | 2017 |
Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Ischemic Attack, Transient; Male; | 2008 |
Regulation of M1-receptor mRNA stability by smilagenin and its significance in improving memory of aged rats.
Topics: 3,3'-Diaminobenzidine; Aging; Analysis of Variance; Animals; Atropine; Binding Sites; Binding, Compe | 2010 |
Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect.
Topics: Animals; Anticonvulsants; Brain; Cell Count; Disease Models, Animal; Dose-Response Relationship, Dru | 2009 |
Assessment of symptomatic and neuroprotective efficacy of Mucuna pruriens seed extract in rodent model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Antiparkinson Agents; C | 2009 |
Differential effects of adenosine antagonists in two models of parkinsonian tremor.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; | 2009 |
A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Behavioral Sy | 2010 |
A novel animal model to evaluate the ability of a drug delivery system to promote the passage through the BBB.
Topics: Animals; Biological Transport; Blood-Brain Barrier; CA1 Region, Hippocampal; Capillary Permeability; | 2010 |
Differential effects of systemic and intraseptal administration of the acetylcholinesterase inhibitor tacrine on the recovery of spatial behavior in an animal model of diencephalic amnesia.
Topics: Acetylcholine; Amnesia; Animals; Behavior, Animal; Cholinesterase Inhibitors; Disease Models, Animal | 2010 |
Tacrine and bis(7)-tacrine attenuate cycloheximide-induced amnesia in mice, with attention to acute toxicity.
Topics: Amnesia; Animals; Behavior, Animal; Cognition; Cycloheximide; Disease Models, Animal; Exploratory Be | 2011 |
ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor.
Topics: Analysis of Variance; Animals; Blood Glucose; Brain; Calcium; Caspase 3; Cell Death; Cholinesterase | 2011 |
Cognitive dysfunctions induced by a cholinergic blockade and Aβ 25-35 peptide are attenuated by salvianolic acid B.
Topics: Amyloid beta-Peptides; Animals; Animals, Newborn; Benzofurans; Cholinergic Antagonists; Cholinestera | 2011 |
Tacrine and its analogues impair mitochondrial function and bioenergetics: a lipidomic analysis in rat brain.
Topics: Adenosine Triphosphatases; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Choline | 2012 |
Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Coumaric Aci | 2012 |
Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins.
Topics: Analysis of Variance; Animals; Cholinergic Antagonists; Cholinesterase Inhibitors; Disease Models, A | 2012 |
Combretum mucronatum and Capparis thonningii prevent scopolamine-induced memory deficit in mice.
Topics: Administration, Oral; Animals; Antioxidants; Avoidance Learning; Brain; Capparis; Cholinesterase Inh | 2013 |
Tacrine is implicated in oxidative stress in the laboratory guinea pig model.
Topics: Alzheimer Disease; Animals; Antioxidants; Brain; Caspase 3; Chemical and Drug Induced Liver Injury; | 2012 |
Local injections of the 5-hydroxytryptamine antagonist mianserin into substantia nigra pars reticulata block tremulous jaw movements in rats: studies with a putative model of Parkinsonian tremor.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injections; | 2003 |
[Effect of dimethyl diphenyl bicarboxylate (DDB) on 9-amino-1,2,3,4-tetrahydroacridine-induced hepatotoxicity in mice].
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A1; Dioxoles; Disease Models, | 2001 |
Blockade of adenosine A2A receptors antagonizes parkinsonian tremor in the rat tacrine model by an action on specific striatal regions.
Topics: Adenosine A2 Receptor Antagonists; Animals; Behavior, Animal; Corpus Striatum; Disease Models, Anima | 2004 |
Effects of the anticholinesterase drug tacrine on the development of PTZ kindling and on learning and memory processes in mice.
Topics: Analysis of Variance; Animals; Avoidance Learning; Cholinesterase Inhibitors; Disease Models, Animal | 2000 |
Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243.
Topics: Analysis of Variance; Animals; Cholinergic Agents; Disease Models, Animal; Dopamine Agonists; Dose-R | 2005 |
(+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration.
Topics: Alkaloids; Alzheimer Disease; Aminoquinolines; Animals; Animals, Newborn; Apoptosis; Cerebellum; Cho | 2004 |
SSR181507, a dopamine D(2) receptor antagonist and 5-HT(1A) receptor agonist, alleviates disturbances of novelty discrimination in a social context in rats, a putative model of selective attention deficit.
Topics: Age Factors; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Clozapine; De | 2005 |
Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine.
Topics: Alkaloids; Animals; Avoidance Learning; Behavior, Animal; Brain Diseases; Cognition Disorders; Disea | 2006 |
Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease.
Topics: Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Rela | 2006 |
Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Brain; Dementia; Disease Models, Animal; Donepezi | 2008 |
Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Antihypertensive Agents; Disease Models, Animal; Guan | 2008 |
[The effect of amiridine and tacrine on reversible capture of neuromediators in experimental memory disorders].
Topics: Aminoquinolines; Animals; Biogenic Monoamines; Cholinesterase Inhibitors; Disease Models, Animal; Ma | 1995 |
Effects of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1 -H-1-benzazepin-8-yl)-1-propanone fumarate (TAK-147), a novel acetylcholinesterase inhibitor, on impaired learning and memory in animal models.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Benzazepines; Brain; Diazepam; Disease Models, | 1996 |
Biphasic effect of tacrine on acetylcholine release in rat brain via M1 and M2 receptors.
Topics: Acetylcholine; Alzheimer Disease; Analysis of Variance; Animals; Atropine; Brain; Cholinesterase Inh | 1996 |
Tacrine improves working memory deficit caused by permanent occlusion of bilateral common carotid arteries in rats.
Topics: Animals; Carotid Artery, Common; Carotid Stenosis; Cholinesterase Inhibitors; Disease Models, Animal | 1997 |
Ameliorative effect of tacrine on spatial memory deficit in chronic two-vessel occluded rats is reversible and mediated by muscarinic M1 receptor stimulation.
Topics: Acetylcholine; Animals; Carotid Stenosis; Cerebral Cortex; Dementia; Disease Models, Animal; Dose-Re | 2000 |
Dimebon improves learning in animals with experimental Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Aziridines; Choline; Cholinesterase Inhibitors; Dise | 2000 |
The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics.
Topics: Administration, Oral; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Disease Models, | 2000 |
[Cholinesterase inhibitor].
Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; | 1991 |
Tetrahydroaminoacridine improves the spatial acquisition deficit produced by nucleus basalis lesions in rats.
Topics: Acetylcholinesterase; Aminoacridines; Animals; Avoidance Learning; Basal Ganglia; Behavior, Animal; | 1990 |
[Study on Alzheimer's disease and the animal disease model--special reference to acetylcholinergic system].
Topics: Acetylcholine; Alzheimer Disease; Animals; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Di | 1989 |