tacrine has been researched along with Degenerative Diseases, Central Nervous System in 15 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Unfortunately, currently available treatments for neurodegenerative disorders can only relieve the symptoms but not modify the pathological processes." | 2.72 | Promising tacrine/huperzine A-based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget. ( Carlier, PR; Cui, W; Fu, H; Han, Y; Hu, S; Li, W; Luo, J; Mak, S; Pang, Y; Pi, R; Tsim, KW, 2021) |
| "Contemporary methods of treatment of neurodegenerative diseases (NDs) are limited and mainly symptomatic." | 1.33 | [Mitochondria as the target for neuroprotectors]. ( Bachurin, SO; Kireeva, EG; Shevtsova, EF, 2005) |
| "Manganese was incorporated in the structure of the selected antioxidants to mimic the superoxide dismutase (SOD) and to increase radical scavenging ability." | 1.32 | Manganese-based complexes of radical scavengers as neuroprotective agents. ( Boonchoong, P; Kammasud, N; Sumanont, Y; Vajragupta, O; Watanabe, H; Wongkrajang, Y, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 4 (26.67) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalli, A | 1 |
| Bolognesi, ML | 1 |
| Minarini, A | 1 |
| Rosini, M | 1 |
| Tumiatti, V | 1 |
| Recanatini, M | 1 |
| Melchiorre, C | 1 |
| Rook, Y | 1 |
| Schmidtke, KU | 1 |
| Gaube, F | 2 |
| Schepmann, D | 1 |
| Wünsch, B | 1 |
| Heilmann, J | 1 |
| Lehmann, J | 2 |
| Winckler, T | 2 |
| González-Muñoz, GC | 2 |
| Arce, MP | 2 |
| López, B | 1 |
| Pérez, C | 2 |
| Villarroya, M | 2 |
| López, MG | 2 |
| García, AG | 1 |
| Conde, S | 2 |
| Rodríguez-Franco, MI | 2 |
| Wang, Y | 1 |
| Guan, XL | 1 |
| Wu, PF | 1 |
| Wang, CM | 1 |
| Cao, H | 1 |
| Li, L | 1 |
| Guo, XJ | 1 |
| Wang, F | 1 |
| Xie, N | 1 |
| Jiang, FC | 1 |
| Chen, JG | 1 |
| Romero, A | 1 |
| Otto, R | 1 |
| Penzis, R | 1 |
| Adolph, O | 1 |
| Föhr, KJ | 1 |
| Warncke, P | 1 |
| Robaa, D | 1 |
| Appenroth, D | 1 |
| Fleck, C | 1 |
| Enzensperger, C | 1 |
| Hiremathad, A | 1 |
| Keri, RS | 1 |
| Esteves, AR | 1 |
| Cardoso, SM | 1 |
| Chaves, S | 1 |
| Santos, MA | 1 |
| Gabr, M | 1 |
| Murugan, NA | 1 |
| Fantacuzzi, M | 1 |
| Amoroso, R | 1 |
| Carradori, S | 1 |
| De Filippis, B | 1 |
| Moreira, NCDS | 2 |
| Tamarozzi, ER | 2 |
| Lima, JEBF | 2 |
| Piassi, LO | 2 |
| Carvalho, I | 2 |
| Passos, GA | 2 |
| Sakamoto-Hojo, ET | 2 |
| Mak, S | 1 |
| Li, W | 1 |
| Fu, H | 1 |
| Luo, J | 1 |
| Cui, W | 1 |
| Hu, S | 1 |
| Pang, Y | 1 |
| Carlier, PR | 1 |
| Tsim, KW | 1 |
| Pi, R | 1 |
| Han, Y | 1 |
| Lee, JS | 1 |
| Kim, HG | 1 |
| Lee, HW | 1 |
| Han, JM | 1 |
| Lee, SK | 1 |
| Kim, DW | 1 |
| Saravanakumar, A | 1 |
| Son, CG | 1 |
| Vajragupta, O | 1 |
| Boonchoong, P | 1 |
| Sumanont, Y | 1 |
| Watanabe, H | 1 |
| Wongkrajang, Y | 1 |
| Kammasud, N | 1 |
| Shevtsova, EF | 1 |
| Kireeva, EG | 1 |
| Bachurin, SO | 1 |
| Ringman, JM | 1 |
| Cummings, JL | 1 |
4 reviews available for tacrine and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Multi-target-directed ligands to combat neurodegenerative diseases.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Binding Sites; Calcium | 2008 |
Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.
Topics: Humans; Neurodegenerative Diseases; Polyphenols; Resveratrol; Stilbenes; Structure-Activity Relation | 2022 |
Promising tacrine/huperzine A-based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget.
Topics: Acetylcholinesterase; Alkaloids; Animals; Cholinesterase Inhibitors; Drug Combinations; Drug Deliver | 2021 |
Current and emerging pharmacological treatment options for dementia.
Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Human | 2006 |
11 other studies available for tacrine and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents.
Topics: Alzheimer Disease; Butyrylcholinesterase; Carbolines; Cholinesterase Inhibitors; Excitatory Amino Ac | 2010 |
Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases.
Topics: Humans; Molecular Structure; Neuroblastoma; Neurodegenerative Diseases; Neuroprotective Agents; Oxid | 2010 |
Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases.
Topics: Acetylcholinesterase; Aging; Animals; Butyrylcholinesterase; CA1 Region, Hippocampal; Cell Line, Tum | 2012 |
Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases.
Topics: Antioxidants; Cell Line, Tumor; Cell Survival; Humans; Mitochondria; Molecular Structure; Neurodegen | 2014 |
Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.
Topics: Animals; Carbolines; Cholinesterase Inhibitors; Computational Biology; Excitatory Amino Acid Antagon | 2015 |
Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzimidazoles; Cholinesterase Inhibitors; Humans; Neurode | 2018 |
Discovery of biphenyl pyrazole scaffold for neurodegenerative diseases: A novel class of acetylcholinesterase-centered multitargeted ligands.
Topics: Acetylcholinesterase; Binding Sites; Blood-Brain Barrier; Cell Line, Tumor; Cell Survival; Cholinest | 2020 |
Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer's Disease Model.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Neuroblastoma | 2022 |
Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer's Disease Model.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Neuroblastoma | 2022 |
Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer's Disease Model.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Neuroblastoma | 2022 |
Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer's Disease Model.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Neuroblastoma | 2022 |
Hippocampal memory enhancing activity of pine needle extract against scopolamine-induced amnesia in a mouse model.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Cell Prolif | 2015 |
Manganese-based complexes of radical scavengers as neuroprotective agents.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Dopamine; Flavonoids; Free Radical Scavengers; In Vitr | 2003 |
[Mitochondria as the target for neuroprotectors].
Topics: Animals; Antiparkinson Agents; Brain; Cell Death; Cells, Cultured; Dopamine Agents; Ginkgo biloba; I | 2005 |