tacrine has been researched along with Cholera Infantum in 7 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The safety of tacrine (Cognex), a centrally active, reversible acetylcholinesterase inhibitor approved in 1993 for the treatment of mild to moderate dementia of the Alzheimer type, was evaluated in 2,706 patients with Alzheimer disease (AD) in clinical trials and in 9861 patients with AD in a treatment investigational new drug (TIND) program." | 4.80 | Safety of tacrine: clinical trials, treatment IND, and postmarketing experience. ( Berghoff, WG; DeJong, R; Dombey, SL; Gracon, SI; Knapp, MJ; Kraemer, D; Lobbestael, SJ; Luscombe, FA; Pierce, M; Symons, J, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Poon, WY | 1 |
| McCain, KR | 1 |
| Sawyer, TS | 1 |
| Spiller, HA | 1 |
| Gauthier, S | 1 |
| Gauthier, L | 1 |
| Gracon, SI | 1 |
| Knapp, MJ | 1 |
| Berghoff, WG | 1 |
| Pierce, M | 1 |
| DeJong, R | 1 |
| Lobbestael, SJ | 1 |
| Symons, J | 1 |
| Dombey, SL | 1 |
| Luscombe, FA | 1 |
| Kraemer, D | 1 |
| Faber, RA | 1 |
| Negro, PJ | 1 |
| Whitehead, A | 1 |
| Omar, RZ | 1 |
| Higgins, JP | 1 |
| Savaluny, E | 1 |
| Turner, RM | 1 |
| Thompson, SG | 1 |
| Molloy, DW | 1 |
| Guyatt, GH | 1 |
| Wilson, DB | 1 |
| Duke, R | 1 |
| Rees, L | 1 |
| Singer, J | 1 |
2 reviews available for tacrine and Cholera Infantum
| Article | Year |
|---|---|
What have we learned from the THA trials to facilitate testing of new AChE inhibitors.
Topics: Alzheimer Disease; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibitors; Clinical Trial | 1993 |
Safety of tacrine: clinical trials, treatment IND, and postmarketing experience.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Chemical and Drug Induced Liver Injury; Chi-Squar | 1998 |
1 trial available for tacrine and Cholera Infantum
| Article | Year |
|---|---|
Effect of tetrahydroaminoacridine on cognition, function and behaviour in Alzheimer's disease.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Chemical and Drug Induced Liver Injury; Cogniti | 1991 |
4 other studies available for tacrine and Cholera Infantum
| Article | Year |
|---|---|
A latent normal distribution model for analysing ordinal responses with applications in meta-analysis.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Cholineste | 2004 |
Evaluation of centrally acting cholinesterase inhibitor exposures in adults.
Topics: Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Donepezil; Female; Galantamine; Gastroint | 2007 |
Enhancing the tolerability of tacrine with propantheline.
Topics: Aged; Alzheimer Disease; Cholinergic Antagonists; Cholinesterase Inhibitors; Drug Administration Sch | 1999 |
Meta-analysis of ordinal outcomes using individual patient data.
Topics: Alzheimer Disease; Anti-Ulcer Agents; Arthritis; Bayes Theorem; Cholinesterase Inhibitors; Cognition | 2001 |