tacrine has been researched along with Cerebral Ischemia in 8 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The neuroprotective effects of GTS-21 [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride] were studied and compared with those of nicotine, 9-amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate (THA) and pentobarbital-Na (PB) using a cerebral ischemia model in Mongolian gerbils." | 3.70 | Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils. ( Miyake, H; Nanri, M; Watanabe, H; Yamamoto, J, 1998) |
| "Manganese was incorporated in the structure of the selected antioxidants to mimic the superoxide dismutase (SOD) and to increase radical scavenging ability." | 1.32 | Manganese-based complexes of radical scavengers as neuroprotective agents. ( Boonchoong, P; Kammasud, N; Sumanont, Y; Vajragupta, O; Watanabe, H; Wongkrajang, Y, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ke, Z | 1 |
| Hu, S | 1 |
| Cui, W | 1 |
| Sun, J | 1 |
| Zhang, S | 1 |
| Mak, S | 1 |
| Wang, J | 1 |
| Tang, J | 1 |
| Pang, Y | 2 |
| Han, Y | 2 |
| Tong, K | 1 |
| Shu, XJ | 1 |
| Liu, W | 1 |
| Zhang, L | 1 |
| Yang, R | 1 |
| Yi, HL | 1 |
| Li, CL | 1 |
| Ye, YJ | 1 |
| Ai, YX | 1 |
| Xu, AJ | 1 |
| Chen, Z | 1 |
| Yanai, K | 1 |
| Huang, YW | 1 |
| Wei, EQ | 1 |
| Vajragupta, O | 1 |
| Boonchoong, P | 1 |
| Sumanont, Y | 1 |
| Watanabe, H | 2 |
| Wongkrajang, Y | 1 |
| Kammasud, N | 1 |
| Zhao, Q | 1 |
| Murakami, Y | 1 |
| Tohda, M | 1 |
| Obi, R | 1 |
| Shimada, Y | 1 |
| Matsumoto, K | 1 |
| Amar, K | 1 |
| Wilcock, GK | 1 |
| Scot, M | 1 |
| Lewis, T | 1 |
| Nanri, M | 1 |
| Yamamoto, J | 1 |
| Miyake, H | 1 |
| Wu, DC | 1 |
| Xiao, XQ | 1 |
| Ng, AK | 1 |
| Chen, PM | 1 |
| Chung, W | 1 |
| Lee, NT | 1 |
| Carlier, PR | 1 |
| Pang, YP | 1 |
| Yu, AC | 1 |
| Han, YF | 1 |
| Wu, D | 1 |
| Xiao, X | 1 |
1 trial available for tacrine and Cerebral Ischemia
| Article | Year |
|---|---|
The presence of leuko-araiosis in patients with Alzheimer's disease predicts poor tolerance to tacrine, but does not discriminate responders from non-responders.
Topics: Alzheimer Disease; Brain; Brain Ischemia; Demyelinating Diseases; Double-Blind Method; Female; Geria | 1997 |
7 other studies available for tacrine and Cerebral Ischemia
| Article | Year |
|---|---|
Bis(propyl)-cognitin potentiates rehabilitation of treadmill exercise after a transient focal cerebral ischemia, possibly via inhibiting NMDA receptor and regulating VEGF expression.
Topics: Animals; Brain Ischemia; Exercise Test; Gene Expression; Male; Rats; Rats, Sprague-Dawley; Receptors | 2019 |
Effect of bis(7)-tacrine on cognition in rats with chronic cerebral ischemia.
Topics: Animals; Apoptosis; Brain Ischemia; Chronic Disease; Cognition; Hippocampus; Male; Maze Learning; Ne | 2012 |
Effect of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-1-propanone fumarate, a novel acetylcholinesterase inhibitor, on spatial cognitive impairment induced by chronic cerebral hypoperfusion in rats.
Topics: Animals; Benzazepines; Brain; Brain Ischemia; Cholinesterase Inhibitors; Coloring Agents; Donepezil; | 2002 |
Manganese-based complexes of radical scavengers as neuroprotective agents.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Dopamine; Flavonoids; Free Radical Scavengers; In Vitr | 2003 |
Chotosan, a kampo formula, ameliorates chronic cerebral hypoperfusion-induced deficits in object recognition behaviors and central cholinergic systems in mice.
Topics: Acetylcholinesterase; Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Cere | 2007 |
Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils.
Topics: Animals; Avoidance Learning; Behavior, Animal; Benzylidene Compounds; Brain Ischemia; Cell Death; GA | 1998 |
Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected].
Topics: Alzheimer Disease; Animals; Animals, Newborn; Apoptosis; Astrocytes; Brain Ischemia; Cells, Cultured | 2000 |