tacrine has been researched along with Carcinoma, Hepatocellular in 6 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clinical trials with tacrine (THA) and its principal (1-OH) metabolite (velnacrine) for the treatment of Alzheimer's disease have been hampered by adverse hepatic events that were undetected in preclinical studies." | 1.29 | Cytotoxicity of tacrine and velnacrine metabolites in cultured rat, dog and human hepatocytes. ( Curren, RD; Viau, CJ; Wallace, K, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Niklas, J | 1 |
| Noor, F | 1 |
| Heinzle, E | 1 |
| Ku, KL | 1 |
| Tsai, CT | 1 |
| Chang, WM | 1 |
| Shen, ML | 1 |
| Wu, CT | 1 |
| Liao, HF | 1 |
| An, RB | 1 |
| Sohn, DH | 1 |
| Jeong, GS | 1 |
| Kim, YC | 3 |
| Viau, CJ | 1 |
| Curren, RD | 1 |
| Wallace, K | 1 |
| Cho, H | 1 |
| Jun, JY | 2 |
| Song, EK | 1 |
| Kang, KH | 1 |
| Baek, HY | 1 |
| Ko, YS | 1 |
| Oh, H | 1 |
| Lee, HS | 1 |
| Kim, T | 1 |
| Chai, KY | 1 |
| Chung, HT | 1 |
| Kwon, TO | 1 |
| Jeong, OS | 1 |
| Yun, YG | 1 |
6 other studies available for tacrine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2.
Topics: Amiodarone; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pr | 2009 |
Hepatoprotective effect of Cirsium arisanense Kitamura in tacrine-treated hepatoma Hep 3B cells and C57BL mice.
Topics: Animals; Antioxidants; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Chemical and Drug | 2008 |
In vitro hepatoprotective compounds from Suaeda glauca.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chenopodiaceae; Chlorogenic Acid; Drugs, Chinese Herbal | 2008 |
Cytotoxicity of tacrine and velnacrine metabolites in cultured rat, dog and human hepatocytes.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cells, Cultur | 1993 |
Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Ficusin; Heterocyclic Compounds, 3-Rin | 2001 |
Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells.
Topics: Angelica; Carcinoma, Hepatocellular; Coumarins; Furans; Furocoumarins; Humans; Medicine, East Asian | 2002 |