tacrine has been researched along with Brain Ischemia in 8 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The neuroprotective effects of GTS-21 [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride] were studied and compared with those of nicotine, 9-amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate (THA) and pentobarbital-Na (PB) using a cerebral ischemia model in Mongolian gerbils." | 3.70 | Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils. ( Miyake, H; Nanri, M; Watanabe, H; Yamamoto, J, 1998) |
| "Manganese was incorporated in the structure of the selected antioxidants to mimic the superoxide dismutase (SOD) and to increase radical scavenging ability." | 1.32 | Manganese-based complexes of radical scavengers as neuroprotective agents. ( Boonchoong, P; Kammasud, N; Sumanont, Y; Vajragupta, O; Watanabe, H; Wongkrajang, Y, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ke, Z | 1 |
| Hu, S | 1 |
| Cui, W | 1 |
| Sun, J | 1 |
| Zhang, S | 1 |
| Mak, S | 1 |
| Wang, J | 1 |
| Tang, J | 1 |
| Pang, Y | 2 |
| Han, Y | 2 |
| Tong, K | 1 |
| Shu, XJ | 1 |
| Liu, W | 1 |
| Zhang, L | 1 |
| Yang, R | 1 |
| Yi, HL | 1 |
| Li, CL | 1 |
| Ye, YJ | 1 |
| Ai, YX | 1 |
| Xu, AJ | 1 |
| Chen, Z | 1 |
| Yanai, K | 1 |
| Huang, YW | 1 |
| Wei, EQ | 1 |
| Vajragupta, O | 1 |
| Boonchoong, P | 1 |
| Sumanont, Y | 1 |
| Watanabe, H | 2 |
| Wongkrajang, Y | 1 |
| Kammasud, N | 1 |
| Zhao, Q | 1 |
| Murakami, Y | 1 |
| Tohda, M | 1 |
| Obi, R | 1 |
| Shimada, Y | 1 |
| Matsumoto, K | 1 |
| Amar, K | 1 |
| Wilcock, GK | 1 |
| Scot, M | 1 |
| Lewis, T | 1 |
| Nanri, M | 1 |
| Yamamoto, J | 1 |
| Miyake, H | 1 |
| Wu, DC | 1 |
| Xiao, XQ | 1 |
| Ng, AK | 1 |
| Chen, PM | 1 |
| Chung, W | 1 |
| Lee, NT | 1 |
| Carlier, PR | 1 |
| Pang, YP | 1 |
| Yu, AC | 1 |
| Han, YF | 1 |
| Wu, D | 1 |
| Xiao, X | 1 |
1 trial available for tacrine and Brain Ischemia
| Article | Year |
|---|---|
The presence of leuko-araiosis in patients with Alzheimer's disease predicts poor tolerance to tacrine, but does not discriminate responders from non-responders.
Topics: Alzheimer Disease; Brain; Brain Ischemia; Demyelinating Diseases; Double-Blind Method; Female; Geria | 1997 |
7 other studies available for tacrine and Brain Ischemia
| Article | Year |
|---|---|
Bis(propyl)-cognitin potentiates rehabilitation of treadmill exercise after a transient focal cerebral ischemia, possibly via inhibiting NMDA receptor and regulating VEGF expression.
Topics: Animals; Brain Ischemia; Exercise Test; Gene Expression; Male; Rats; Rats, Sprague-Dawley; Receptors | 2019 |
Effect of bis(7)-tacrine on cognition in rats with chronic cerebral ischemia.
Topics: Animals; Apoptosis; Brain Ischemia; Chronic Disease; Cognition; Hippocampus; Male; Maze Learning; Ne | 2012 |
Effect of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-1-propanone fumarate, a novel acetylcholinesterase inhibitor, on spatial cognitive impairment induced by chronic cerebral hypoperfusion in rats.
Topics: Animals; Benzazepines; Brain; Brain Ischemia; Cholinesterase Inhibitors; Coloring Agents; Donepezil; | 2002 |
Manganese-based complexes of radical scavengers as neuroprotective agents.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Dopamine; Flavonoids; Free Radical Scavengers; In Vitr | 2003 |
Chotosan, a kampo formula, ameliorates chronic cerebral hypoperfusion-induced deficits in object recognition behaviors and central cholinergic systems in mice.
Topics: Acetylcholinesterase; Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Cere | 2007 |
Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils.
Topics: Animals; Avoidance Learning; Behavior, Animal; Benzylidene Compounds; Brain Ischemia; Cell Death; GA | 1998 |
Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected].
Topics: Alzheimer Disease; Animals; Animals, Newborn; Apoptosis; Astrocytes; Brain Ischemia; Cells, Cultured | 2000 |