tacrine has been researched along with Brain Disorders in 6 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we tested the effects of a synthesized juxtaposition (named SCR1693) composed of an acetylcholinesterase inhibitor (AChEI) and a calcium channel blocker (CCB) on the hyperhomocysteinemia (HHcy)-induced AD rat model, and found that SCR1693 remarkably improved the HHcy-induced memory deficits and preserved dendrite morphologies as well as spine density by upregulating synapse-associated proteins PSD95 and synapsin-1." | 7.80 | Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats. ( Chen, R; Hu, J; Liu, R; Liu, X; Tian, Q; Wang, JZ; Wang, P; Wang, Q; Wang, XC; Xia, Y; Zeng, K, 2014) |
| " In this study, we tested the effects of a synthesized juxtaposition (named SCR1693) composed of an acetylcholinesterase inhibitor (AChEI) and a calcium channel blocker (CCB) on the hyperhomocysteinemia (HHcy)-induced AD rat model, and found that SCR1693 remarkably improved the HHcy-induced memory deficits and preserved dendrite morphologies as well as spine density by upregulating synapse-associated proteins PSD95 and synapsin-1." | 3.80 | Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats. ( Chen, R; Hu, J; Liu, R; Liu, X; Tian, Q; Wang, JZ; Wang, P; Wang, Q; Wang, XC; Xia, Y; Zeng, K, 2014) |
| ") produced amnesia in the passive avoidance task, chronic administration of tacrine (1, 3 and 10 mg/kg, once a day for 1 week) improved the amnesia." | 1.28 | The effect of tacrine (THA) on cycloheximide- and basal forebrain lesion-induced memory deficit in rats. ( Kameyama, T; Katoh, A; Maruyama, E; Nabeshima, T, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xia, Y | 1 |
| Liu, R | 1 |
| Chen, R | 1 |
| Tian, Q | 1 |
| Zeng, K | 1 |
| Hu, J | 1 |
| Liu, X | 1 |
| Wang, Q | 1 |
| Wang, P | 1 |
| Wang, XC | 1 |
| Wang, JZ | 1 |
| Xu, Z | 1 |
| Zheng, H | 1 |
| Law, SL | 1 |
| Dong So, D | 1 |
| Han, Y | 1 |
| Xue, H | 1 |
| Riekkinen, P | 1 |
| Riekkinen, M | 1 |
| Sirviö, J | 1 |
| Abe, K | 1 |
| Horiuchi, M | 1 |
| Yoshimura, K | 1 |
| Nabeshima, T | 1 |
| Maruyama, E | 1 |
| Katoh, A | 1 |
| Kameyama, T | 1 |
| Sattin, A | 1 |
| Muhoberac, BB | 1 |
| Aprison, MH | 1 |
| Schauf, CL | 1 |
6 other studies available for tacrine and Brain Disorders
| Article | Year |
|---|---|
Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats.
Topics: Animals; Brain Diseases; Calcium Channel Blockers; Cholinesterase Inhibitors; Disease Models, Animal | 2014 |
Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine.
Topics: Alkaloids; Animals; Avoidance Learning; Behavior, Animal; Brain Diseases; Cognition Disorders; Disea | 2006 |
Effects of nicotine on neocortical electrical activity in rats.
Topics: Animals; Brain Diseases; Cerebral Cortex; Cholinergic Fibers; Electroencephalography; Electrophysiol | 1993 |
Potentiation by DSP-4 of EEG slowing and memory impairment in basal forebrain-lesioned rats.
Topics: Animals; Benzylamines; Brain Diseases; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Drug | 1997 |
The effect of tacrine (THA) on cycloheximide- and basal forebrain lesion-induced memory deficit in rats.
Topics: Administration, Oral; Amnesia; Animals; Aphasia; Ataxia; Avoidance Learning; Behavior, Animal; Brain | 1991 |
Tetrahydroaminoacridine (THA) as a pharmacological probe in Alzheimer's disease (AD) and other neurodegenerative disorders.
Topics: Aluminum; Alzheimer Disease; Aminoacridines; Animals; Brain Diseases; Humans; Models, Biological; Ta | 1989 |