tacrine has been researched along with Body Weight in 5 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tacrine is a centrally acting, reversible cholinesterase inhibitor that increases synaptic levels of acetylcholine (ACh) and can potentiate the actions of dopamine (DA)." | 1.35 | Long-lasting decreases in cocaine-reinforced behavior following treatment with the cholinesterase inhibitor tacrine in rats selectively bred for drug self-administration. ( Grasing, K; He, S; Yang, Y, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grasing, K | 1 |
| He, S | 1 |
| Yang, Y | 1 |
| Sinz, MW | 1 |
| Woolf, TF | 1 |
| Giovannini, MG | 1 |
| Scali, C | 1 |
| Bartolini, L | 1 |
| Schmidt, B | 1 |
| Pepeu, G | 1 |
| Belles, M | 1 |
| Gomez, M | 1 |
| Domingo, JL | 1 |
| Sanchez, DJ | 1 |
| Mayayo, E | 1 |
| Corbella, J | 1 |
| Kesslak, JP | 1 |
| Korotzer, A | 1 |
| Song, A | 1 |
| Kamali, K | 1 |
| Cotman, CW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Tacrine Effects on Cocaine Self-Administration and Pharmacokinetics[NCT01406522] | Phase 2 | 0 participants (Actual) | Interventional | 2012-10-31 | Withdrawn (stopped due to One of the study medications, tacrine, is no longer clinically available) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for tacrine and Body Weight
| Article | Year |
|---|---|
Long-lasting decreases in cocaine-reinforced behavior following treatment with the cholinesterase inhibitor tacrine in rats selectively bred for drug self-administration.
Topics: Algorithms; Animals; Behavior, Animal; Body Weight; Breeding; Cholinergic Agents; Cholinesterase Inh | 2009 |
Characterization of the induction of rat microsomal cytochrome P450 by tacrine.
Topics: Animals; Benzoflavones; Body Weight; Cholinesterase Inhibitors; Cytochrome P-450 Enzyme System; Enzy | 1997 |
Effect of subchronic treatment with metrifonate and tacrine on brain cholinergic function in aged F344 rats.
Topics: Acetylcholine; Administration, Oral; Aging; Animals; Blood Pressure; Body Weight; Cerebral Cortex; C | 1998 |
Effects of simultaneous administration of desferrioxamine and tacrine in rats.
Topics: Animals; Body Weight; Chelating Agents; Cholinesterase Inhibitors; Deferoxamine; Drug Synergism; Hea | 1998 |
Effects of tetrahydroaminoacridine (THA) on functional recovery after sequential lesion of the entorhinal cortex.
Topics: Acetylcholinesterase; Animals; Benzoxazines; Body Weight; Cerebral Cortex; Conditioning, Operant; Do | 1991 |