Page last updated: 2024-10-21

tacrine and Body Weight

tacrine has been researched along with Body Weight in 5 studies

Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.

Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Research Excerpts

ExcerptRelevanceReference
"Tacrine is a centrally acting, reversible cholinesterase inhibitor that increases synaptic levels of acetylcholine (ACh) and can potentiate the actions of dopamine (DA)."1.35Long-lasting decreases in cocaine-reinforced behavior following treatment with the cholinesterase inhibitor tacrine in rats selectively bred for drug self-administration. ( Grasing, K; He, S; Yang, Y, 2009)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (80.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Grasing, K1
He, S1
Yang, Y1
Sinz, MW1
Woolf, TF1
Giovannini, MG1
Scali, C1
Bartolini, L1
Schmidt, B1
Pepeu, G1
Belles, M1
Gomez, M1
Domingo, JL1
Sanchez, DJ1
Mayayo, E1
Corbella, J1
Kesslak, JP1
Korotzer, A1
Song, A1
Kamali, K1
Cotman, CW1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Tacrine Effects on Cocaine Self-Administration and Pharmacokinetics[NCT01406522]Phase 20 participants (Actual)Interventional2012-10-31Withdrawn (stopped due to One of the study medications, tacrine, is no longer clinically available)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

5 other studies available for tacrine and Body Weight

ArticleYear
Long-lasting decreases in cocaine-reinforced behavior following treatment with the cholinesterase inhibitor tacrine in rats selectively bred for drug self-administration.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 94, Issue:1

    Topics: Algorithms; Animals; Behavior, Animal; Body Weight; Breeding; Cholinergic Agents; Cholinesterase Inh

2009
Characterization of the induction of rat microsomal cytochrome P450 by tacrine.
    Biochemical pharmacology, 1997, Aug-01, Volume: 54, Issue:3

    Topics: Animals; Benzoflavones; Body Weight; Cholinesterase Inhibitors; Cytochrome P-450 Enzyme System; Enzy

1997
Effect of subchronic treatment with metrifonate and tacrine on brain cholinergic function in aged F344 rats.
    European journal of pharmacology, 1998, Jul-31, Volume: 354, Issue:1

    Topics: Acetylcholine; Administration, Oral; Aging; Animals; Blood Pressure; Body Weight; Cerebral Cortex; C

1998
Effects of simultaneous administration of desferrioxamine and tacrine in rats.
    Veterinary and human toxicology, 1998, Volume: 40, Issue:5

    Topics: Animals; Body Weight; Chelating Agents; Cholinesterase Inhibitors; Deferoxamine; Drug Synergism; Hea

1998
Effects of tetrahydroaminoacridine (THA) on functional recovery after sequential lesion of the entorhinal cortex.
    Brain research, 1991, Aug-23, Volume: 557, Issue:1-2

    Topics: Acetylcholinesterase; Animals; Benzoxazines; Body Weight; Cerebral Cortex; Conditioning, Operant; Do

1991