tacrine has been researched along with Amyloid Deposits in 4 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Also, reduction of amyloid plaque burden and gliosis in the cortex and hippocampus was assessed." | 1.46 | The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease. ( Fernandez, AP; Futch, HS; Herrero-Labrador, R; Marco-Contelles, J; Martínez-Murillo, R; Romero, A; Samadi, A; Serrano, J; Serrano, MP; Unzeta, M, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalli, A | 1 |
| Bolognesi, ML | 1 |
| Minarini, A | 1 |
| Rosini, M | 1 |
| Tumiatti, V | 1 |
| Recanatini, M | 1 |
| Melchiorre, C | 1 |
| Mohamed, T | 1 |
| Yeung, JC | 1 |
| Rao, PP | 1 |
| Serrano, MP | 1 |
| Herrero-Labrador, R | 1 |
| Futch, HS | 1 |
| Serrano, J | 1 |
| Romero, A | 1 |
| Fernandez, AP | 1 |
| Samadi, A | 1 |
| Unzeta, M | 1 |
| Marco-Contelles, J | 1 |
| Martínez-Murillo, R | 1 |
| Riekkinen, M | 1 |
| Soininen, H | 1 |
| Riekkinen, P | 2 |
| Kuikka, J | 1 |
| Laakso, M | 1 |
| Helkala, EL | 1 |
| Partanen, J | 1 |
1 review available for tacrine and Amyloid Deposits
| Article | Year |
|---|---|
Multi-target-directed ligands to combat neurodegenerative diseases.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Binding Sites; Calcium | 2008 |
1 trial available for tacrine and Amyloid Deposits
| Article | Year |
|---|---|
Tetrahydroaminoacridine improves the recency effect in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amygdala; Apolipoprotein E4; Apolipoproteins E; Cerebrovascular Circulation | 1998 |
2 other studies available for tacrine and Amyloid Deposits
| Article | Year |
|---|---|
Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzhydryl Compounds; Butyrylcholinesterase; Cholineste | 2011 |
The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Animals; Cell Survival; Cerebral Cortex; Disease Models, Animal; Donepezil; Glios | 2017 |