tacrine has been researched along with Amnesia in 25 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Amnesia: Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "DuP 996, 3,3-bis(4-pyrindinylmethyl)-1-phenylindolin-2-one, physostigmine (PH), tetrahydroaminoacridine (THA) and 3,4-diaminopyridine (3,4-DAP) were compared for their ability to protect against hypoxia-induced performance deficits in a passive avoidance (PA) task." | 7.68 | Comparison of DuP 996, with physostigmine, THA and 3,4-DAP on hypoxia-induced amnesia in rats. ( Cook, L; DeNoble, KF; DeNoble, VJ; Johnson, LC; Myers, MJ; Scribner, RM; Spencer, KR, 1990) |
| "The potential of heptylphysostigmine tartrate (pyrrolo [2,3b] indol-5-ol, 3,3a,8,8a-hexahydro-1,3a,8-trimethylheptylcarbamate [ester, (3aS-cis)]) (MF201), a new second-generation cholinesterase inhibitor, to antagonize scopolamine-induced amnesia in rats was assessed in an 8-arm radial maze." | 3.69 | An inverted U-shaped curve for heptylphysostigmine on radial maze performance in rats: comparison with other cholinesterase inhibitors. ( Braida, D; Griffini, P; Lamperti, M; Maggi, A; Paladini, E; Sala, M, 1996) |
| "The effects of NIK-247 on cholinesterase, scopolamine-induced amnesia and spontaneous movement were examined and compared with those of the well-known cholinesterase inhibitors tacrine and E-2020." | 3.69 | Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia. ( Kojima, J; Nakajima, K; Nakayama, K; Ochiai, M, 1997) |
| "The effect of NIK-247 on carbon monoxide (CO)-induced amnesia were investigated." | 3.68 | Effects of NIK-247 on CO-induced impairment of passive avoidance in mice. ( Kameyama, T; Kinbara, K; Nabeshima, T; Yoshida, S, 1992) |
| "The authors studied the influence of amiridin and tacrine on learning and memory in mice and rat by passive avoidance conditioning test at norm and under scopolamine induced amnesia as well as of their effect on acetylcholine esterase (AChE) activity in brain cortex homogenates." | 3.68 | [Experimental study of the effects of amiridin and tacrine on learning and memory]. ( Burov, IuV; Kadysheva, LV; Robakidze, TN; Sukhanova, SA, 1991) |
| "The model of amnestic syndrome obtained by treatment with scopolamine during 20 days in rats was used to study anti-amnesic activity of amiridin in comparison with that of tacrine, physostigmine and piracetam." | 3.68 | [Study of anti-amnesic activity of amiridin in a model of amnesic syndrome]. ( Burov, IuV; Kadysheva, LV; Robakidze, TN; Shaposhnikova, GI; Voronin, AE, 1991) |
| "DuP 996, 3,3-bis(4-pyrindinylmethyl)-1-phenylindolin-2-one, physostigmine (PH), tetrahydroaminoacridine (THA) and 3,4-diaminopyridine (3,4-DAP) were compared for their ability to protect against hypoxia-induced performance deficits in a passive avoidance (PA) task." | 3.68 | Comparison of DuP 996, with physostigmine, THA and 3,4-DAP on hypoxia-induced amnesia in rats. ( Cook, L; DeNoble, KF; DeNoble, VJ; Johnson, LC; Myers, MJ; Scribner, RM; Spencer, KR, 1990) |
| "Due to the complex nature of Alzheimer's disease, multi-target-directed ligand approaches are one of the most promising strategies in the search for effective treatments." | 1.42 | Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo. ( Bajda, M; Brus, B; Czerwińska, P; Filipek, B; Gobec, S; Malawska, B; Sałat, K; Więckowska, A; Więckowski, K, 2015) |
| " Consistent with this suggestion, we now demonstrate that chronic administration of tacrine, nefiracetam, and deprenyl, drugs that augment cholinergic function, increases the basal frequency of dentate polysialylated neurons in a manner similar to the enhanced neuroplasticity achieved through complex environment rearing." | 1.33 | Chronic exposure of rats to cognition enhancing drugs produces a neuroplastic response identical to that obtained by complex environment rearing. ( Foley, AG; Murphy, KJ; O'connell, AW; Regan, CM, 2006) |
| " The reversal of scopolamine-induced impairment was characterized by an inverted U-shaped dose-response curve." | 1.30 | Long-lasting antiamnesic effect of a novel anticholinesterase inhibitor (MF268). ( Braida, D; Colibretti, L; Griffini, P; Lamperti, M; Paladini, E; Sala, M, 1998) |
| "The effects of acute and chronic administration of MKC-231, a new choline uptake enhancer, and two other nootropic agents, linopiridine (Dup 996) and tetrahydroaminoacridine (THA) on working memory deficits and decreased hippocampal acetylcholine (ACh) content were studied in a delayed non-matching to sample task, using a T-maze, in ethylcholine aziridinium ion (AF64A)-treated mice." | 1.29 | MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice. ( Abe, E; Itoh, T; Masuda, Y; Murai, S; Odashima, J; Saito, H, 1994) |
| ") produced amnesia in the passive avoidance task, chronic administration of tacrine (1, 3 and 10 mg/kg, once a day for 1 week) improved the amnesia." | 1.28 | The effect of tacrine (THA) on cycloheximide- and basal forebrain lesion-induced memory deficit in rats. ( Kameyama, T; Katoh, A; Maruyama, E; Nabeshima, T, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 18 (72.00) | 18.2507 |
| 2000's | 1 (4.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vidaluc, JL | 1 |
| Calmel, F | 1 |
| Bigg, D | 1 |
| Carilla, E | 1 |
| Stenger, A | 1 |
| Chopin, P | 2 |
| Briley, M | 2 |
| Więckowska, A | 1 |
| Więckowski, K | 1 |
| Bajda, M | 1 |
| Brus, B | 1 |
| Sałat, K | 1 |
| Czerwińska, P | 1 |
| Gobec, S | 1 |
| Filipek, B | 1 |
| Malawska, B | 1 |
| Ahmadi, A | 1 |
| Roghani, M | 1 |
| Noori, S | 1 |
| Nahri-Niknafs, B | 1 |
| Lee, JS | 1 |
| Kim, HG | 1 |
| Lee, HW | 1 |
| Han, JM | 1 |
| Lee, SK | 1 |
| Kim, DW | 1 |
| Saravanakumar, A | 1 |
| Son, CG | 1 |
| Roland, JJ | 1 |
| Levinson, M | 1 |
| Vetreno, RP | 1 |
| Savage, LM | 1 |
| Pan, SY | 1 |
| Zhang, Y | 1 |
| Guo, BF | 1 |
| Han, YF | 1 |
| Ko, KM | 1 |
| Murphy, KJ | 1 |
| Foley, AG | 1 |
| O'connell, AW | 1 |
| Regan, CM | 1 |
| Murai, S | 1 |
| Saito, H | 1 |
| Abe, E | 2 |
| Masuda, Y | 1 |
| Odashima, J | 1 |
| Itoh, T | 1 |
| Yoshida, S | 3 |
| Suzuki, N | 1 |
| Braida, D | 2 |
| Paladini, E | 2 |
| Griffini, P | 2 |
| Lamperti, M | 2 |
| Maggi, A | 1 |
| Sala, M | 2 |
| Maurice, T | 1 |
| Lockhart, BP | 1 |
| Privat, A | 1 |
| Cheng, DH | 1 |
| Ren, H | 1 |
| Tang, XC | 2 |
| Kojima, J | 1 |
| Nakajima, K | 1 |
| Ochiai, M | 1 |
| Nakayama, K | 1 |
| Colibretti, L | 1 |
| Wang, T | 1 |
| Burov, IuV | 3 |
| Borisova, AO | 1 |
| Robakidze, TN | 3 |
| Goncharenko, SB | 1 |
| Nabeshima, T | 4 |
| Kinbara, K | 1 |
| Kameyama, T | 4 |
| Maruyama, E | 1 |
| Katoh, A | 1 |
| Kadysheva, LV | 2 |
| Sukhanova, SA | 1 |
| Voronin, AE | 1 |
| Shaposhnikova, GI | 1 |
| DeNoble, VJ | 1 |
| DeNoble, KF | 1 |
| Spencer, KR | 1 |
| Johnson, LC | 1 |
| Cook, L | 1 |
| Myers, MJ | 1 |
| Scribner, RM | 1 |
| Itoh, J | 1 |
25 other studies available for tacrine and Amnesia
| Article | Year |
|---|---|
Novel [2-(4-piperidinyl)ethyl](thio)ureas: synthesis and antiacetylcholinesterase activity.
Topics: Acetylcholinesterase; Amnesia; Animals; Avoidance Learning; Cholinesterase Inhibitors; Dementia; Dos | 1994 |
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.
Topics: Acetylcholinesterase; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Blood-Brain Barrie | 2015 |
Substituted Aminobenzothiazole Derivatives of Tacrine: Synthesis and Study on Learning and Memory Impairment in Scopolamine-Induced Model of Amnesia in Rat.
Topics: Alzheimer Disease; Amination; Amnesia; Animals; Benzothiazoles; Learning; Male; Maze Learning; Nootr | 2019 |
Hippocampal memory enhancing activity of pine needle extract against scopolamine-induced amnesia in a mouse model.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Cell Prolif | 2015 |
Differential effects of systemic and intraseptal administration of the acetylcholinesterase inhibitor tacrine on the recovery of spatial behavior in an animal model of diencephalic amnesia.
Topics: Acetylcholine; Amnesia; Animals; Behavior, Animal; Cholinesterase Inhibitors; Disease Models, Animal | 2010 |
Tacrine and bis(7)-tacrine attenuate cycloheximide-induced amnesia in mice, with attention to acute toxicity.
Topics: Amnesia; Animals; Behavior, Animal; Cognition; Cycloheximide; Disease Models, Animal; Exploratory Be | 2011 |
Chronic exposure of rats to cognition enhancing drugs produces a neuroplastic response identical to that obtained by complex environment rearing.
Topics: Acetylcholine; Amnesia; Animals; Avoidance Learning; Cognition; Dentate Gyrus; Dose-Response Relatio | 2006 |
MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice.
Topics: Acetylcholine; Acetylcholinesterase; Amnesia; Animals; Aziridines; Choline; Choline Deficiency; Data | 1994 |
Antiamnesic and cholinomimetic side-effects of the cholinesterase inhibitors, physostigmine, tacrine and NIK-247 in rats.
Topics: Administration, Oral; Aminoquinolines; Amnesia; Animals; Avoidance Learning; Body Temperature; Choli | 1993 |
An inverted U-shaped curve for heptylphysostigmine on radial maze performance in rats: comparison with other cholinesterase inhibitors.
Topics: Amnesia; Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Donepezil; Dose | 1996 |
Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction.
Topics: Acetylcholine; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Avoidance Learning; Choli | 1996 |
Huperzine A, a novel promising acetylcholinesterase inhibitor.
Topics: Acetylcholinesterase; Alkaloids; Amnesia; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinerg | 1996 |
Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Amnesia; Animals; Butyrylcholinesterase; C | 1997 |
Long-lasting antiamnesic effect of a novel anticholinesterase inhibitor (MF268).
Topics: Amnesia; Animals; Brain; Cholinesterase Inhibitors; Cognition; Donepezil; Indans; Male; Maze Learnin | 1998 |
Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine.
Topics: Alkaloids; Amnesia; Animals; Cholinesterase Inhibitors; Donepezil; Indans; Male; Maze Learning; Musc | 1998 |
[Effect of the new 9-aminoacridine derivative on the working and long-term memory in rats].
Topics: Acridines; Aminoquinolines; Amnesia; Animals; Cholinesterase Inhibitors; Learning; Male; Memory; Noo | 1999 |
Effects of NIK-247 on CO-induced impairment of passive avoidance in mice.
Topics: Aminoquinolines; Amnesia; Animals; Avoidance Learning; Carbon Monoxide; Cholinesterase Inhibitors; M | 1992 |
Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats.
Topics: Amnesia; Animals; Avoidance Learning; Cognition; Dihydroergotoxine; Dose-Response Relationship, Drug | 1992 |
Reversal effect of DM-9384 on scopolamine-induced acetylcholine depletion in certain regions of the mouse brain.
Topics: Acetylcholine; Amnesia; Animals; Brain Chemistry; Central Nervous System Agents; Male; Mice; Mice, I | 1991 |
The effect of tacrine (THA) on cycloheximide- and basal forebrain lesion-induced memory deficit in rats.
Topics: Administration, Oral; Amnesia; Animals; Aphasia; Ataxia; Avoidance Learning; Behavior, Animal; Brain | 1991 |
[Experimental study of the effects of amiridin and tacrine on learning and memory].
Topics: Acetylcholinesterase; Aminoquinolines; Amnesia; Animals; Cerebral Cortex; Cholinesterase Inhibitors; | 1991 |
[Study of anti-amnesic activity of amiridin in a model of amnesic syndrome].
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Amnesia; Animals; Cerebral Cortex; Choline | 1991 |
Comparison of DuP 996, with physostigmine, THA and 3,4-DAP on hypoxia-induced amnesia in rats.
Topics: 4-Aminopyridine; Amnesia; Animals; Avoidance Learning; Hypoxia; Indoles; Male; Oxygen Consumption; P | 1990 |
Utility of an elevated plus-maze for the evaluation of memory in mice: effects of nootropics, scopolamine and electroconvulsive shock.
Topics: Amnesia; Animals; Electroshock; Injections, Intraventricular; Male; Memory; Mice; Mice, Inbred Strai | 1990 |
Effects of the novel compound NIK-247 on impairment of passive avoidance response in mice.
Topics: Aminoquinolines; Amnesia; Animals; Avoidance Learning; Choline; Cholinesterase Inhibitors; Cyclohexi | 1988 |