tacrine has been researched along with Amentia in 47 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To review the evidence for the effectiveness of cholinesterase inhibitors (donepezil, galantamine, rivastigmine, and tacrine) and the neuropeptide-modifying agent memantine in achieving clinically relevant improvements, primarily in cognition, global function, behavior, and quality of life, for patients with dementia." | 8.84 | Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. ( Booker, L; Cowan, D; Ismaila, A; Levine, M; Oremus, M; Patterson, C; Raina, P; Santaguida, P, 2008) |
| " Therefore, the present study was designed to investigate the influence of antidementia drugs, tacrine and donepezil, on biochemical markers of oxidative stress, glutathione (GSH) and malondialdehyde (MDA), and acetylcholinesterase activity in the brain in a streptozotocin-induced experimental model of dementia in mice." | 7.74 | Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice. ( Agrawal, R; Nath, C; Saxena, G; Singh, SP, 2008) |
| "The goal of this study was to investigate whether donepezil treatment is associated with reduced mortality in nursing home residents who have dementia." | 7.73 | Is donepezil therapy associated with reduced mortality in nursing home residents with dementia? ( Gasper, MC; Lapane, KL; Ott, BR, 2005) |
| "Memantine, a moderate-affinity, uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, has been shown to be effective in dementia, including Alzheimer disease (AD)." | 7.72 | Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy. ( Hartmann, S; Möbius, HJ, 2003) |
| "To investigate the extent to which treatment with tacrine is associated with a reduction in mortality in nursing home residents with dementia." | 7.71 | Tacrine therapy is associated with reduced mortality in nursing home residents with dementia. ( Lapane, KL; Ott, BR, 2002) |
| "To review the evidence for the effectiveness of cholinesterase inhibitors (donepezil, galantamine, rivastigmine, and tacrine) and the neuropeptide-modifying agent memantine in achieving clinically relevant improvements, primarily in cognition, global function, behavior, and quality of life, for patients with dementia." | 4.84 | Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. ( Booker, L; Cowan, D; Ismaila, A; Levine, M; Oremus, M; Patterson, C; Raina, P; Santaguida, P, 2008) |
| "The pharmacological treatment of dementia is particularly difficult because of the uncertainty of the diagnosis and of the underlying pathogenetic processes, and because of the variable severity of the syndrome." | 3.77 | Clinical trials in cognitive impairment in the elderly. ( Boller, F; Forette, F; Panisset, M, 1992) |
| " Therefore, the present study was designed to investigate the influence of antidementia drugs, tacrine and donepezil, on biochemical markers of oxidative stress, glutathione (GSH) and malondialdehyde (MDA), and acetylcholinesterase activity in the brain in a streptozotocin-induced experimental model of dementia in mice." | 3.74 | Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice. ( Agrawal, R; Nath, C; Saxena, G; Singh, SP, 2008) |
| "The goal of this study was to investigate whether donepezil treatment is associated with reduced mortality in nursing home residents who have dementia." | 3.73 | Is donepezil therapy associated with reduced mortality in nursing home residents with dementia? ( Gasper, MC; Lapane, KL; Ott, BR, 2005) |
| "Memantine, a moderate-affinity, uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, has been shown to be effective in dementia, including Alzheimer disease (AD)." | 3.72 | Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy. ( Hartmann, S; Möbius, HJ, 2003) |
| "To investigate the extent to which treatment with tacrine is associated with a reduction in mortality in nursing home residents with dementia." | 3.71 | Tacrine therapy is associated with reduced mortality in nursing home residents with dementia. ( Lapane, KL; Ott, BR, 2002) |
| "The authors studied the influence of amiridin and tacrine on learning and memory in mice and rat by passive avoidance conditioning test at norm and under scopolamine induced amnesia as well as of their effect on acetylcholine esterase (AChE) activity in brain cortex homogenates." | 3.68 | [Experimental study of the effects of amiridin and tacrine on learning and memory]. ( Burov, IuV; Kadysheva, LV; Robakidze, TN; Sukhanova, SA, 1991) |
| "Treatment approaches to memory loss typically use Alzheimer's dementia as the template, and are discussed in this report." | 2.41 | Approaches to memory loss in neuropsychiatric disorders. ( Devi, G; Silver, J, 2000) |
| "The features of apoptotic dose responses typically have been evaluated over a broad dose-response continuum to differentiate apoptotic and necrotic responses." | 2.41 | Apoptosis: biphasic dose responses. ( Calabrese, EJ, 2001) |
| "So far, the treatment of dementia focuses essentially on the consequences of neuronal dysfunction or cell loss by either a palliative approach addressing psychosis, behavior or anxiety and depression, or by substitution of deficient neurotransmitters with quasi no success." | 2.39 | [Toward a treatment for dementia]. ( Ghika, J, 1995) |
| "Developing treatment guidelines for Alzheimer's disease and other dementias depends primarily on a literature review." | 2.39 | Developing treatment guidelines for Alzheimer's disease and other dementias. ( Rabins, PV, 1996) |
| "Huperzine A (HupA) is a selective inhibitor of acetylcholinesterase (AChE) and has been shown to significantly reduce cognitive impairment in animal models of dementia." | 1.39 | Huperzine A, but not tacrine, stimulates S100B secretion in astrocyte cultures. ( Abib, R; Gonçalves, CA; Guerra, MC; Leite, MC; Lunardi, P; Nardin, P, 2013) |
| "Inflammation has been recently implicated in pathogenesis of dementia disorders." | 1.34 | Effect of anti-dementia drugs on LPS induced neuroinflammation in mice. ( Agrawal, R; Nath, C; Shukla, R; Tyagi, E, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (8.51) | 18.7374 |
| 1990's | 20 (42.55) | 18.2507 |
| 2000's | 20 (42.55) | 29.6817 |
| 2010's | 3 (6.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vidaluc, JL | 1 |
| Calmel, F | 1 |
| Bigg, D | 1 |
| Carilla, E | 1 |
| Stenger, A | 1 |
| Chopin, P | 1 |
| Briley, M | 1 |
| Atri, A | 1 |
| Ishola, IO | 1 |
| Adeyemi, OO | 1 |
| Agbaje, EO | 1 |
| Tota, S | 1 |
| Shukla, R | 2 |
| Lunardi, P | 1 |
| Nardin, P | 1 |
| Guerra, MC | 1 |
| Abib, R | 1 |
| Leite, MC | 1 |
| Gonçalves, CA | 1 |
| Hartmann, S | 1 |
| Möbius, HJ | 1 |
| Werber, EA | 1 |
| Gandelman-Marton, R | 1 |
| Klein, C | 1 |
| Rabey, JM | 1 |
| Fuchsberger, T | 1 |
| Möller, HJ | 1 |
| Hampel, H | 1 |
| Warner, J | 3 |
| Butler, R | 3 |
| Arya, P | 2 |
| Miyanaga, K | 1 |
| Gasper, MC | 1 |
| Ott, BR | 2 |
| Lapane, KL | 2 |
| Wuntakal, B | 1 |
| Ringman, JM | 1 |
| Cummings, JL | 2 |
| Lyketsos, CG | 1 |
| Colenda, CC | 1 |
| Beck, C | 1 |
| Blank, K | 1 |
| Doraiswamy, MP | 1 |
| Kalunian, DA | 1 |
| Yaffe, K | 1 |
| Tyagi, E | 1 |
| Agrawal, R | 2 |
| Nath, C | 2 |
| Saxena, G | 1 |
| Singh, SP | 1 |
| Qaseem, A | 1 |
| Snow, V | 1 |
| Cross, JT | 1 |
| Forciea, MA | 1 |
| Hopkins, R | 1 |
| Shekelle, P | 1 |
| Adelman, A | 1 |
| Mehr, D | 1 |
| Schellhase, K | 1 |
| Campos-Outcalt, D | 1 |
| Santaguida, P | 2 |
| Owens, DK | 1 |
| Raina, P | 1 |
| Ismaila, A | 1 |
| Patterson, C | 1 |
| Cowan, D | 1 |
| Levine, M | 1 |
| Booker, L | 1 |
| Oremus, M | 1 |
| Graham, L | 1 |
| Kaye, WH | 1 |
| Sitaram, N | 1 |
| Weingartner, H | 1 |
| Ebert, MH | 1 |
| Smallberg, S | 1 |
| Gillin, JC | 1 |
| Summers, WK | 1 |
| Viesselman, JO | 1 |
| Marsh, GM | 1 |
| Candelora, K | 1 |
| Ghika, J | 1 |
| McSwain, ML | 1 |
| Forman, LM | 1 |
| Cacabelos, R | 1 |
| Wilcock, GK | 1 |
| Scott, MI | 1 |
| Ganesan, R | 1 |
| Standish, T | 1 |
| Molloy, DW | 1 |
| Darzins, P | 1 |
| Orange, JB | 1 |
| Hutchinson, M | 1 |
| Fazzini, E | 1 |
| Maany, I | 1 |
| Ojer Tsakiridu, D | 1 |
| Dosantos Hernández, JO | 1 |
| Larrabe Medina, J | 1 |
| Sánchez Casado, JI | 1 |
| Sologuren Echenagusia, A | 1 |
| Rabins, PV | 1 |
| Nichols, ME | 1 |
| Scarbrough, TJ | 1 |
| Schneider, LS | 1 |
| Katsube, N | 1 |
| Sunaga, K | 1 |
| Aishita, H | 1 |
| Chuang, DM | 1 |
| Ishitani, R | 1 |
| Cabeza-Alvarez, CI | 1 |
| González-Rubio, M | 1 |
| García-Montero, R | 1 |
| Alvarez-Tejerina, A | 1 |
| Pryse-Phillips, W | 1 |
| Murakami, Y | 1 |
| Ikenoya, M | 1 |
| Matsumoto, K | 1 |
| Li, H | 1 |
| Watanabe, H | 1 |
| Devi, G | 1 |
| Silver, J | 1 |
| Calabrese, EJ | 1 |
| Forette, F | 1 |
| Panisset, M | 1 |
| Boller, F | 1 |
| Thal, LJ | 1 |
| Burov, IuV | 1 |
| Robakidze, TN | 1 |
| Kadysheva, LV | 1 |
| Sukhanova, SA | 1 |
| Otomo, E | 1 |
| Nilsson, L | 1 |
| Adem, A | 1 |
| Hardy, J | 1 |
| Winblad, B | 1 |
| Nordberg, A | 1 |
21 reviews available for tacrine and Amentia
| Article | Year |
|---|---|
Effective pharmacological management of Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Dementia; Disease Progression; Donepezil; G | 2011 |
[Current therapy of patients with dementia].
Topics: Activities of Daily Living; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Controlled Cli | 2003 |
Dementia.
Topics: Alzheimer Disease; Antipsychotic Agents; Benzodiazepines; Cognition; Dementia; Donepezil; Galantamin | 2004 |
Dementia.
Topics: Alzheimer Disease; Dementia; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Memantine; Nootr | 2004 |
Dementia.
Topics: Alzheimer Disease; Benzodiazepines; Dementia; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; | 2005 |
Current and emerging pharmacological treatment options for dementia.
Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Human | 2006 |
Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline.
Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excit | 2008 |
[Toward a treatment for dementia].
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Humans; Middle Aged; Nerve Growth Fact | 1995 |
[Tacrine: first generation of anti-dementia drugs].
Topics: Animals; Dementia; Humans; Tacrine | 1995 |
Dementia: the failing brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dementia; Dementia, Vascular; Humans; Middle Aged; Parki | 1995 |
New treatments for dementia. Myth, magic, and science.
Topics: Acetylcarnitine; Adult; Aged; Aged, 80 and over; Attitude to Death; Attitude to Health; Canada; Cult | 1994 |
[Piracetam, nimodipine and tacrine in the pharmacologic treatment of dementia: bibliographic review].
Topics: Aged; Aged, 80 and over; Dementia; Double-Blind Method; Humans; Nimodipine; Nootropic Agents; Pirace | 1996 |
Developing treatment guidelines for Alzheimer's disease and other dementias.
Topics: Alzheimer Disease; Antipsychotic Agents; Behavior Therapy; Cognition Disorders; Dementia; Humans; Me | 1996 |
Dementia in the elderly.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Female; | 1997 |
Diffuse Lewy body disease: a common yet misdiagnosed dementia in which neuroleptics may be contraindicated.
Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Brain; Cholinesterase Inhibitors; Contraindications; | 1998 |
New therapeutic approaches to cognitive impairment.
Topics: Aged; Alzheimer Disease; Antioxidants; Carbamates; Cholinesterase Inhibitors; Cognition Disorders; D | 1998 |
Do we have drugs for dementia? No.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Ginkgo biloba; Humans; Indans; Ne | 1999 |
Approaches to memory loss in neuropsychiatric disorders.
Topics: Aging; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholinesterase Inhibitors; Dementia; D | 2000 |
Apoptosis: biphasic dose responses.
Topics: Animals; Antioxidants; Apoptosis; Cycloheximide; Dementia; Dimethylformamide; Dose-Response Relation | 2001 |
Clinical trials in cognitive impairment in the elderly.
Topics: Activities of Daily Living; Alzheimer Disease; Cognition; Dementia; Humans; Tacrine | 1992 |
Assessment issues in clinical trials of tetrahydroaminoacridine and studies to alter decline in Alzheimer disease.
Topics: Alzheimer Disease; Clinical Trials as Topic; Dementia; Humans; Psychiatric Status Rating Scales; Tac | 1991 |
3 trials available for tacrine and Amentia
| Article | Year |
|---|---|
The clinical use of P300 event related potentials for the evaluation of cholinesterase inhibitors treatment in demented patients.
Topics: Acetylcholine; Aged; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Cognition Disorders; De | 2003 |
Cholinesterase inhibition in Parkinson's disease.
Topics: Aged; Cholinesterase Inhibitors; Dementia; Female; Humans; Male; Parkinson Disease; Pilot Projects; | 1996 |
Clinical trials in cognitive impairment in the elderly.
Topics: Activities of Daily Living; Alzheimer Disease; Cognition; Dementia; Humans; Tacrine | 1992 |
24 other studies available for tacrine and Amentia
| Article | Year |
|---|---|
Novel [2-(4-piperidinyl)ethyl](thio)ureas: synthesis and antiacetylcholinesterase activity.
Topics: Acetylcholinesterase; Amnesia; Animals; Avoidance Learning; Cholinesterase Inhibitors; Dementia; Dos | 1994 |
Combretum mucronatum and Capparis thonningii prevent scopolamine-induced memory deficit in mice.
Topics: Administration, Oral; Animals; Antioxidants; Avoidance Learning; Brain; Capparis; Cholinesterase Inh | 2013 |
Huperzine A, but not tacrine, stimulates S100B secretion in astrocyte cultures.
Topics: Alkaloids; Animals; Astrocytes; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Dementia; | 2013 |
Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy.
Topics: Adult; Aged; Aged, 80 and over; Carbamates; Cholinesterase Inhibitors; Dementia; Donepezil; Dose-Res | 2003 |
[Treatment of dementia].
Topics: Cerebrovascular Circulation; Cholinesterase Inhibitors; Dementia; Exercise; Galantamine; Humans; Nut | 2005 |
Is donepezil therapy associated with reduced mortality in nursing home residents with dementia?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cohort Studies; Cross-Sectional Studies; Databases, Fact | 2005 |
Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease.
Topics: Aged; Alkaloids; Alzheimer Disease; Brain; Caregivers; Cholinesterase Inhibitors; Cognition Disorder | 2006 |
Effect of anti-dementia drugs on LPS induced neuroinflammation in mice.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Brain; Cholinesterase Inhibitors; Dementia; Don | 2007 |
Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Brain; Dementia; Disease Models, Animal; Donepezi | 2008 |
Summaries for patients. Drug treatment for patients with dementia: American College of Physicians and American Academy of Family Physicians recommendations.
Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excit | 2008 |
Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians.
Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excit | 2008 |
AAFP and ACP release guideline on dementia treatment.
Topics: Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Guidelines as Topic; Humans; Indans; Me | 2008 |
Modest facilitation on memory in dementia with combined lecithin and anticholinerestase treatment.
Topics: Aged; Cholinesterase Inhibitors; Dementia; Drug Therapy, Combination; Humans; Memory; Middle Aged; P | 1982 |
Use of THA in treatment of Alzheimer-like dementia: pilot study in twelve patients.
Topics: Acridines; Adult; Aged; Alzheimer Disease; Dementia; Drug Evaluation; Female; Humans; Male; Memory; | 1981 |
Severe parkinsonian symptom development on combination treatment with tacrine and haloperidol.
Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Dementia; Drug Therapy, Combination; Haloperidol; Hum | 1995 |
Tacrine for senile dementia of Alzheimer's or Lewy body type.
Topics: Alzheimer Disease; Brain; Dementia; Humans; Lewy Bodies; Tacrine | 1994 |
Adverse interaction of tacrine and haloperidol.
Topics: Aged; Dementia; Drug Interactions; Drug Therapy, Combination; Female; Haloperidol; Humans; Parkinson | 1996 |
ONO-1603, a potential antidementia drug, delays age-induced apoptosis and suppresses overexpression of glyceraldehyde-3-phosphate dehydrogenase in cultured central nervous system neurons.
Topics: Animals; Apoptosis; Cells, Cultured; Cellular Senescence; Central Nervous System; Cholinesterase Inh | 1999 |
[Parkinsonian syndrome related to tacrine].
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Dementia; Humans; Male; Parkinson Disease, Secon | 1999 |
Ameliorative effect of tacrine on spatial memory deficit in chronic two-vessel occluded rats is reversible and mediated by muscarinic M1 receptor stimulation.
Topics: Acetylcholine; Animals; Carotid Stenosis; Cerebral Cortex; Dementia; Disease Models, Animal; Dose-Re | 2000 |
Tacrine therapy is associated with reduced mortality in nursing home residents with dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cohort Studies; Comorbidity; | 2002 |
[Experimental study of the effects of amiridin and tacrine on learning and memory].
Topics: Acetylcholinesterase; Aminoquinolines; Amnesia; Animals; Cerebral Cortex; Cholinesterase Inhibitors; | 1991 |
[Drug therapy of Alzheimer's disease. General concepts on nootropic drugs].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amantadine; Aminoacridines; Dementia; gamma-Aminobutyric | 1988 |
Do tetrahydroaminoacridine (THA) and physostigmine restore acetylcholine release in Alzheimer brains via nicotinic receptors?
Topics: Acetylcholine; Aged; Alzheimer Disease; Aminoacridines; Dementia; Female; Frontal Lobe; Humans; In V | 1987 |