tacrine has been researched along with Aging in 49 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "3H-Paroxetine (PA) binding was studied in the frontal cortex (FC) and hippocampus (H) of 4 mos (young), 15 mos (adult) and 24 mos (aged) old Fischer 344 rats." | 5.29 | Aging and 3H-paroxetine binding in rat brain: effect of imipramine and tetrahydroacridine. ( Arora, RC; Crayton, JW; Gulati, A, 1993) |
| " We used matrix-assisted laser desorption/ionization mass spectrometry imaging in combination with multivariate analysis to visualize in anatomical detail metabolic effects of aging and tacrine-mediated acetylcholinesterase inhibition on comprehensive neurotransmitter systems in multiple mouse brain regions of 12-week-old and 14-month-old mice." | 4.12 | Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems. ( Andrén, PE; Fridjonsdottir, E; Mantas, I; Nilsson, A; Odell, LR; Schembri, LS; Shariatgorji, R; Svenningsson, P; Vallianatou, T, 2022) |
| "We investigated the effect of tetrahydroaminoacridine, a cholinesterase inhibitor and D-cycloserine (a partial glycine-B agonist of the NMDA receptor complex) on the defect of water maze spatial navigation in rats induced by aging." | 3.70 | Tetrahydroaminoacridine and D-cycloserine stimulate acquisition of water maze spatial navigation in aged rats. ( Aura, J; Riekkinen, M; Riekkinen, P, 1998) |
| "4) Velnacrine was shown to bind to both albumin and alpha 1-acid glycoprotein, but together they did not account for total binding." | 2.68 | Variability in the plasma protein binding of velnacrine (1-hydroxy tacrine hydrochloride). A potential agent for Alzheimer's disease. ( Ford, JM; Roberts, CJ; Wood, DM, 1996) |
| "Tacrine was the first cholinesterase inhibitor approved by regulatory agencies, followed by donepezil, rivastigmine and recently galantamine." | 2.41 | Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors. ( Jann, MW; Shirley, KL; Small, GW, 2002) |
| "Treatment approaches to memory loss typically use Alzheimer's dementia as the template, and are discussed in this report." | 2.41 | Approaches to memory loss in neuropsychiatric disorders. ( Devi, G; Silver, J, 2000) |
| "Alzheimer's disease is the most common dementing illness affecting over 4 million Americans." | 2.40 | Providing dental care for patients diagnosed with Alzheimer's disease. ( Henry, RG; Wekstein, DR, 1997) |
| "Tacrine disposition was maintained with age, and area under the concentration-time curve and clearance in old rats were similar to those in young rats for all drugs tested as was bioavailability." | 1.37 | Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. ( Aw, CC; Browne, ER; Chen, CP; Goh, CW; Lee, JH, 2011) |
| "The tacrine effects were characterized by increased hepatic mitochondrial State 4 respiration in rats and decreased State 3 respiration in humans." | 1.30 | Elucidation of mitochondrial effects by tetrahydroaminoacridine (tacrine) in rat, dog, monkey and human hepatic parenchymal cells. ( Braden, TK; de la Iglesia, FA; Lalwani, ND; Robertson, DG; Urda, ER, 1998) |
| "Velnacrine maleate is a novel, orally active acetylcholinesterase inhibitor of the acridine class with a longer duration of action than physostigmine." | 1.29 | Velnacrine maleate improves delayed matching performance by aged monkeys. ( Buccafusco, JJ; Jackson, WJ; Rush, DK; Terry, AV; Turk, DJ, 1995) |
| "3H-Paroxetine (PA) binding was studied in the frontal cortex (FC) and hippocampus (H) of 4 mos (young), 15 mos (adult) and 24 mos (aged) old Fischer 344 rats." | 1.29 | Aging and 3H-paroxetine binding in rat brain: effect of imipramine and tetrahydroacridine. ( Arora, RC; Crayton, JW; Gulati, A, 1993) |
| "Nicotine (0." | 1.29 | Depletion of serotonin, dopamine and noradrenaline in aged rats decreases the therapeutic effect of nicotine, but not of tetrahydroaminoacridine. ( Aroviita, L; Kivipelto, M; Riekkinen, M; Riekkinen, P; Taskila, K, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (4.08) | 18.7374 |
| 1990's | 35 (71.43) | 18.2507 |
| 2000's | 6 (12.24) | 29.6817 |
| 2010's | 5 (10.20) | 24.3611 |
| 2020's | 1 (2.04) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Guan, XL | 1 |
| Wu, PF | 1 |
| Wang, CM | 1 |
| Cao, H | 1 |
| Li, L | 1 |
| Guo, XJ | 1 |
| Wang, F | 1 |
| Xie, N | 1 |
| Jiang, FC | 1 |
| Chen, JG | 1 |
| Fridjonsdottir, E | 2 |
| Vallianatou, T | 2 |
| Mantas, I | 1 |
| Shariatgorji, R | 1 |
| Nilsson, A | 2 |
| Schembri, LS | 1 |
| Odell, LR | 1 |
| Svenningsson, P | 2 |
| Andrén, PE | 2 |
| Shariatgorji, M | 1 |
| Källback, P | 1 |
| Schintu, N | 1 |
| Tait, DS | 1 |
| Chase, EA | 1 |
| Brown, VJ | 1 |
| Hu, Y | 1 |
| Wang, Z | 1 |
| Zhang, R | 1 |
| Wu, P | 1 |
| Xia, Z | 1 |
| Orsi, A | 1 |
| Rees, D | 1 |
| Goh, CW | 1 |
| Aw, CC | 1 |
| Lee, JH | 1 |
| Chen, CP | 1 |
| Browne, ER | 1 |
| Jann, MW | 1 |
| Shirley, KL | 1 |
| Small, GW | 1 |
| Sabolek, HR | 1 |
| Bunce, JG | 1 |
| Giuliana, D | 1 |
| Chrobak, JJ | 1 |
| Jones, DN | 1 |
| Barnes, JC | 1 |
| Kirkby, DL | 1 |
| Higgins, GA | 1 |
| Jackson, WJ | 1 |
| Buccafusco, JJ | 1 |
| Terry, AV | 1 |
| Turk, DJ | 1 |
| Rush, DK | 1 |
| Shaddock, JG | 1 |
| Feuers, RJ | 1 |
| Chou, MW | 1 |
| Swenson, DH | 1 |
| Casciano, DA | 1 |
| Bassant, MH | 1 |
| Jazat-Poindessous, F | 1 |
| Lamour, Y | 1 |
| Giménez-Roldán, S | 1 |
| Ohta, H | 1 |
| Matsumoto, K | 1 |
| Shimizu, M | 1 |
| Watanabe, H | 1 |
| Fitten, LJ | 2 |
| Perryman, KM | 1 |
| O'Neill, J | 2 |
| Halgren, E | 2 |
| Gheusi, G | 1 |
| Bluthe, RM | 1 |
| Goodall, G | 1 |
| Dantzer, R | 1 |
| Glasky, AJ | 2 |
| Melchior, CL | 2 |
| Pirzadeh, B | 1 |
| Heydari, N | 1 |
| Ritzmann, RF | 2 |
| Kling, A | 1 |
| Arora, RC | 1 |
| Gulati, A | 1 |
| Crayton, JW | 1 |
| Wood, DM | 1 |
| Ford, JM | 1 |
| Roberts, CJ | 1 |
| Smith, RD | 1 |
| Grzelak, ME | 1 |
| Belanger, B | 1 |
| Morgan, CA | 1 |
| Yavich, L | 1 |
| Sirviö, J | 4 |
| Haapalinna, A | 2 |
| Puumala, T | 1 |
| Koivisto, E | 1 |
| Heinonen, E | 1 |
| Riekkinen, PJ | 2 |
| Riekkinen, M | 4 |
| Aroviita, L | 1 |
| Kivipelto, M | 1 |
| Taskila, K | 1 |
| Riekkinen, P | 13 |
| Jäkälä, P | 2 |
| Henry, RG | 1 |
| Wekstein, DR | 1 |
| Scali, C | 2 |
| Giovannini, MG | 2 |
| Prosperi, C | 1 |
| Bartolini, L | 2 |
| Pepeu, G | 2 |
| Aura, J | 2 |
| Robertson, DG | 1 |
| Braden, TK | 1 |
| Urda, ER | 1 |
| Lalwani, ND | 1 |
| de la Iglesia, FA | 1 |
| Schmidt, B | 1 |
| Stemmelin, J | 1 |
| Cassel, JC | 1 |
| Will, B | 1 |
| Kelche, C | 1 |
| Siembieda, DW | 1 |
| Crawford, KC | 1 |
| Fisher, A | 1 |
| Refai, D | 1 |
| Kosasa, T | 1 |
| Kuriya, Y | 1 |
| Matsui, K | 1 |
| Yamanishi, Y | 1 |
| Devi, G | 1 |
| Silver, J | 1 |
| Chopin, P | 1 |
| Colpaert, FC | 1 |
| Marien, M | 1 |
| Zhang, X | 1 |
| Tian, JY | 1 |
| Svensson, AL | 1 |
| Gong, ZH | 1 |
| Meyerson, B | 1 |
| Nordberg, A | 1 |
| Harju, M | 1 |
| Dierssen, M | 2 |
| Màrmol, F | 2 |
| Vivas, NM | 2 |
| Clos, MV | 2 |
| Badia, A | 2 |
| Feuerstein, TJ | 1 |
| Lehmann, J | 1 |
| Sauermann, W | 1 |
| van Velthoven, V | 1 |
| Jackisch, R | 1 |
| Sirvioö, J | 1 |
| Lammintausta, R | 1 |
| Gascón, S | 1 |
| Lahtinen, H | 1 |
| Valjakka, A | 1 |
| Benesová, O | 2 |
| Kristofíková, Z | 2 |
| Tejkalová, H | 2 |
| Aaltonen, M | 2 |
| Binková, B | 1 |
| Tucek, S | 1 |
| Dlohozková, N | 1 |
| Hodges, H | 1 |
| Ribeiro, AM | 1 |
| Gray, JA | 1 |
| Marchbanks, RM | 1 |
| Boller, F | 1 |
| Forette, F | 1 |
| Russell, RW | 1 |
6 reviews available for tacrine and Aging
| Article | Year |
|---|---|
Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors.
Topics: Aging; Alzheimer Disease; Biological Availability; Carbamates; Cholinesterase Inhibitors; Donepezil; | 2002 |
[Alzheimer's disease].
Topics: Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Humans; Tacrine | 1995 |
Providing dental care for patients diagnosed with Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Caregivers; Cholinesterase | 1997 |
Approaches to memory loss in neuropsychiatric disorders.
Topics: Aging; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholinesterase Inhibitors; Dementia; D | 2000 |
Alzheimer's disease and THA: a review of the cholinergic theory and of preliminary results.
Topics: Aging; Alzheimer Disease; Aminoacridines; Clinical Trials as Topic; Cognition; Double-Blind Method; | 1989 |
Behavioral correlates of presynaptic events in the cholinergic neurotransmitter system.
Topics: Acetylcholine; Aging; Behavior; Choline; Choline O-Acetyltransferase; Cholinergic Fibers; Cholineste | 1988 |
2 trials available for tacrine and Aging
| Article | Year |
|---|---|
Variability in the plasma protein binding of velnacrine (1-hydroxy tacrine hydrochloride). A potential agent for Alzheimer's disease.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Binding, Compet | 1996 |
Alzheimer's disease and THA: a review of the cholinergic theory and of preliminary results.
Topics: Aging; Alzheimer Disease; Aminoacridines; Clinical Trials as Topic; Cognition; Double-Blind Method; | 1989 |
42 other studies available for tacrine and Aging
| Article | Year |
|---|---|
Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases.
Topics: Acetylcholinesterase; Aging; Animals; Butyrylcholinesterase; CA1 Region, Hippocampal; Cell Line, Tum | 2012 |
Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems.
Topics: Aging; Animals; Brain; Brain Mapping; Cholinesterase Inhibitors; Dopaminergic Neurons; gamma-Aminobu | 2022 |
Molecular imaging identifies age-related attenuation of acetylcholine in retrosplenial cortex in response to acetylcholinesterase inhibition.
Topics: Acetylcholine; Aging; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Male; Mice, Inbred C57BL; | 2019 |
Tacrine improves reversal learning in older rats.
Topics: Aging; Animals; Attention; Cholinesterase Inhibitors; Male; Rats; Reversal Learning; Tacrine | 2013 |
Regulation of M1-receptor mRNA stability by smilagenin and its significance in improving memory of aged rats.
Topics: 3,3'-Diaminobenzidine; Aging; Analysis of Variance; Animals; Atropine; Binding Sites; Binding, Compe | 2010 |
Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats.
Topics: Aging; Animals; Biological Availability; Brain; Cholinesterase Inhibitors; Cholinesterases; Donepezi | 2011 |
Within-subject memory decline in middle-aged rats: effects of intraseptal tacrine.
Topics: Acetylcholine; Aging; Animals; Catheterization; Cholinergic Fibers; Drug Administration Routes; Earl | 2004 |
Age-associated impairments in a test of attention: evidence for involvement of cholinergic systems.
Topics: Aging; Animals; Attention; Behavior, Animal; Cholinergic Agents; Exploratory Behavior; Male; Mecamyl | 1995 |
Velnacrine maleate improves delayed matching performance by aged monkeys.
Topics: Aging; Alzheimer Disease; Animals; Behavior, Animal; Cholinesterase Inhibitors; Dose-Response Relati | 1995 |
Genotoxicity of tacrine in primary hepatocytes isolated from B6C3F1 mice and aged ad libitum and calorie restricted Fischer 344 rats.
Topics: Aging; Animals; Cells, Cultured; DNA Repair; Energy Intake; Liver; Male; Mice; Mutagenicity Tests; R | 1995 |
Metabolic response to tacrine (THA) and physostigmine in the aged rat brain.
Topics: Aging; Animals; Autoradiography; Brain; Carbon Radioisotopes; Cholinesterase Inhibitors; Deoxyglucos | 1995 |
Paeoniflorin attenuates learning impairment of aged rats in operant brightness discrimination task.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Bridged-Ring Compounds; Discrimi | 1994 |
Influence of cholinesterase inhibitors on cortical slow-wave activity in aging nonhuman primate.
Topics: Aging; Amodiaquine; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Electrodes; Electroencephal | 1994 |
Ethological study of the effects of tetrahydroaminoacridine (THA) on social recognition in rats.
Topics: Aging; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Interperso | 1994 |
Effect of AIT-082, a purine analog, on working memory in normal and aged mice.
Topics: Aging; Aminobenzoates; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Hypoxanthines; Mal | 1994 |
Effect of age and strain on working memory in mice as measured by win-shift paradigm.
Topics: Aging; Animals; Male; Memory, Short-Term; Mice; Mice, Inbred C57BL; Models, Psychological; Physostig | 1993 |
Aging and 3H-paroxetine binding in rat brain: effect of imipramine and tetrahydroacridine.
Topics: Aging; Animals; Brain; Imipramine; Male; Paroxetine; Rats; Rats, Inbred F344; Tacrine; Tritium | 1993 |
The effects of tropicamide on mydriasis in young rats exhibiting a natural deficit in passive-avoidance responding.
Topics: Aging; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Injections, Subcutaneous; Musc | 1996 |
The systemic administration of tacrine or selegiline facilitate spatial learning in aged fisher 344 rats.
Topics: Aging; Animals; Cholinesterase Inhibitors; Drug Evaluation, Preclinical; Escape Reaction; Male; Maze | 1996 |
Depletion of serotonin, dopamine and noradrenaline in aged rats decreases the therapeutic effect of nicotine, but not of tetrahydroaminoacridine.
Topics: Aging; Animals; Behavior, Animal; Dopamine; Fenclonine; Frontal Lobe; Male; Nicotine; Norepinephrine | 1996 |
Combined cholinergic and 5-HT2 receptor activation suppresses thalamocortical oscillations in aged rats.
Topics: Aging; Amphetamines; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Drug Synergism; Electroenc | 1997 |
Tacrine administration enhances extracellular acetylcholine in vivo and restores the cognitive impairment in aged rats.
Topics: Acetylcholine; Administration, Oral; Aging; Analysis of Variance; Animals; Avoidance Learning; Behav | 1997 |
Tetrahydroaminoacridine and D-cycloserine stimulate acquisition of water maze spatial navigation in aged rats.
Topics: Aging; Animals; Cholinesterase Inhibitors; Cycloserine; Drug Synergism; Female; Male; Maze Learning; | 1998 |
Elucidation of mitochondrial effects by tetrahydroaminoacridine (tacrine) in rat, dog, monkey and human hepatic parenchymal cells.
Topics: Adult; Aged; Aging; Animals; DNA, Mitochondrial; Dogs; Female; Haplorhini; Humans; Liver; Male; Midd | 1998 |
Effect of subchronic treatment with metrifonate and tacrine on brain cholinergic function in aged F344 rats.
Topics: Acetylcholine; Administration, Oral; Aging; Animals; Blood Pressure; Body Weight; Cerebral Cortex; C | 1998 |
Sensitivity to cholinergic drug treatments of aged rats with variable degrees of spatial memory impairment.
Topics: Aging; Animals; Brain; Cholinergic Agents; Escape Reaction; Female; Maze Learning; Mental Recall; Mo | 1999 |
Divided attention-enhancing effects of AF102B and THA in aging monkeys.
Topics: Aging; Animals; Attention; Cholinergic Agents; Cholinesterase Inhibitors; Female; Macaca radiata; Ma | 1999 |
Inhibitory effects of donepezil hydrochloride (E2020) on cholinesterase activity in brain and peripheral tissues of young and aged rats.
Topics: Aging; Animals; Brain; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Erythrocytes; Indans; | 1999 |
Pre-training blocks the improving effect of tetrahydroaminoacridine and D-cycloserine on spatial navigation performance in aged rats.
Topics: Aging; Animals; Cholinesterase Inhibitors; Conditioning, Psychological; Cycloserine; Male; Maze Lear | 2000 |
Effects of acute and subchronic administration of dexefaroxan, an alpha(2)-adrenoceptor antagonist, on memory performance in young adult and aged rodents.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Ag | 2002 |
Chronic treatments with tacrine and (-)-nicotine induce different changes of nicotinic and muscarinic acetylcholine receptors in the brain of aged rat.
Topics: Aging; Animals; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Drug Administration S | 2002 |
Comparative effects of alpha-2 receptor agents and THA on the performance of adult and aged rats in the delayed non-matching to position task.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 1992 |
Post-train administration of 9-amino-1,2,3,4-tetrahydroacridine enhances passive avoidance retention and decreases beta-adrenoceptor-linked cyclic AMP formation in middle-aged rats.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Avoidance Learning; Cerebral Cortex; Conditioning, Psyc | 1992 |
The autoinhibitory feedback control of acetylcholine release in human neocortex tissue.
Topics: Acetylcholine; Aging; Atropine; Cerebral Cortex; Electric Stimulation; Feedback; Humans; In Vitro Te | 1992 |
Combination of atipamezole and tetrahydroaminoacridine/pilocarpine treatment suppresses high voltage spindle activity in aged rats.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Drug Combinations; Electrophysiology; Imidazoles; Male | 1991 |
Acute effects of tetrahydroaminoacridine on beta-adrenoceptor-linked cyclic AMP accumulation in brain of young and middle-aged rats.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Brain; Cerebral Cortex; Cholinesterase Inhibitors; Cycl | 1991 |
Tetrahydroaminoacridine improves passive avoidance retention defects induced by aging and medial septal lesion but not by fimbria-fornix lesion.
Topics: Aging; Animals; Avoidance Learning; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Hippocam | 1991 |
Experimental study of long-term administration of cholinesterase inhibitors in aging rats.
Topics: Aging; Animals; Behavior, Animal; Brain; Male; Pyrithioxin; Rats; Rats, Inbred Strains; Tacrine; Tim | 1991 |
Tetrahydroaminoacridine alleviates medial septal lesion-induced and age-related spatial reference but not working memory deficits.
Topics: Aging; Animals; Brain Mapping; Cholinergic Fibers; Discrimination Learning; Escape Reaction; Hippoca | 1991 |
The evaluation of nootropic drug effects in aging rats.
Topics: Aging; Aminoacridines; Animals; Brain; Dose-Response Relationship, Drug; Male; Memory; Neurotransmit | 1990 |
Tetrahydroaminoacridine inhibits high voltage spindle activity in aged rats after acute and chronic treatment.
Topics: Aging; Animals; Brain; Cholinesterases; Electroencephalography; Electrophysiology; Female; Pilocarpi | 1991 |
Low dose tetrahydroaminoacridine (THA) improves cognitive function but does not affect brain acetylcholine in rats.
Topics: Acetylcholine; Acetylcholinesterase; Aging; Aminoacridines; Animals; Brain; Cognition; Ethanol; Fema | 1990 |