tacrine has been researched along with Age-Related Memory Disorders in 42 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we tested the effects of a synthesized juxtaposition (named SCR1693) composed of an acetylcholinesterase inhibitor (AChEI) and a calcium channel blocker (CCB) on the hyperhomocysteinemia (HHcy)-induced AD rat model, and found that SCR1693 remarkably improved the HHcy-induced memory deficits and preserved dendrite morphologies as well as spine density by upregulating synapse-associated proteins PSD95 and synapsin-1." | 7.80 | Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats. ( Chen, R; Hu, J; Liu, R; Liu, X; Tian, Q; Wang, JZ; Wang, P; Wang, Q; Wang, XC; Xia, Y; Zeng, K, 2014) |
| " Therefore, the present study was designed to investigate the influence of antidementia drugs, tacrine and donepezil, on biochemical markers of oxidative stress, glutathione (GSH) and malondialdehyde (MDA), and acetylcholinesterase activity in the brain in a streptozotocin-induced experimental model of dementia in mice." | 7.74 | Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice. ( Agrawal, R; Nath, C; Saxena, G; Singh, SP, 2008) |
| " In this study, we tested the effects of a synthesized juxtaposition (named SCR1693) composed of an acetylcholinesterase inhibitor (AChEI) and a calcium channel blocker (CCB) on the hyperhomocysteinemia (HHcy)-induced AD rat model, and found that SCR1693 remarkably improved the HHcy-induced memory deficits and preserved dendrite morphologies as well as spine density by upregulating synapse-associated proteins PSD95 and synapsin-1." | 3.80 | Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats. ( Chen, R; Hu, J; Liu, R; Liu, X; Tian, Q; Wang, JZ; Wang, P; Wang, Q; Wang, XC; Xia, Y; Zeng, K, 2014) |
| "A definite diagnosis of Alzheimer's disease can be made only at autopsy." | 3.77 | Alternatives in the treatment of memory loss in patients with Alzheimer's disease. ( Volger, BW, 1991) |
| " Therefore, the present study was designed to investigate the influence of antidementia drugs, tacrine and donepezil, on biochemical markers of oxidative stress, glutathione (GSH) and malondialdehyde (MDA), and acetylcholinesterase activity in the brain in a streptozotocin-induced experimental model of dementia in mice." | 3.74 | Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice. ( Agrawal, R; Nath, C; Saxena, G; Singh, SP, 2008) |
| "Treatment approaches to memory loss typically use Alzheimer's dementia as the template, and are discussed in this report." | 2.41 | Approaches to memory loss in neuropsychiatric disorders. ( Devi, G; Silver, J, 2000) |
| " Chronic administration of B3C for 21 days prevented the memory impairments of the AD model mice in a dose-dependent manner." | 1.43 | Bis(propyl)-cognitin Prevents β-amyloid-induced Memory Deficits as Well as Synaptic Formation and Plasticity Impairments via the Activation of PI3-K Pathway. ( An, P; Chen, X; Feng, C; Han, Y; Huang, M; Jiang, L; Wang, Q; Wang, Y; Wei, X; Xu, S, 2016) |
| "Phenytoin-treated kindled animals were associated with learning and memory deficit, while tacrine supplementation improved memory deficit with increased seizure severity score." | 1.40 | Adjuvant anticholinesterase therapy for the management of epilepsy-induced memory deficit: a critical pre-clinical study. ( Goel, RK; Mishra, A, 2014) |
| "Tacrine was infused into the medial septum just prior to testing." | 1.33 | Intraseptal tacrine-induced disruptions of spatial memory performance. ( Bunce, JG; Chrobak, JJ; Sabolek, HR, 2005) |
| "Manganese was incorporated in the structure of the selected antioxidants to mimic the superoxide dismutase (SOD) and to increase radical scavenging ability." | 1.32 | Manganese-based complexes of radical scavengers as neuroprotective agents. ( Boonchoong, P; Kammasud, N; Sumanont, Y; Vajragupta, O; Watanabe, H; Wongkrajang, Y, 2003) |
| "The effects of acute and chronic administration of MKC-231, a new choline uptake enhancer, and two other nootropic agents, linopiridine (Dup 996) and tetrahydroaminoacridine (THA) on working memory deficits and decreased hippocampal acetylcholine (ACh) content were studied in a delayed non-matching to sample task, using a T-maze, in ethylcholine aziridinium ion (AF64A)-treated mice." | 1.29 | MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice. ( Abe, E; Itoh, T; Masuda, Y; Murai, S; Odashima, J; Saito, H, 1994) |
| ") produced amnesia in the passive avoidance task, chronic administration of tacrine (1, 3 and 10 mg/kg, once a day for 1 week) improved the amnesia." | 1.28 | The effect of tacrine (THA) on cycloheximide- and basal forebrain lesion-induced memory deficit in rats. ( Kameyama, T; Katoh, A; Maruyama, E; Nabeshima, T, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.38) | 18.7374 |
| 1990's | 13 (30.95) | 18.2507 |
| 2000's | 11 (26.19) | 29.6817 |
| 2010's | 17 (40.48) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ishihara, Y | 1 |
| Hirai, K | 1 |
| Miyamoto, M | 1 |
| Goto, G | 1 |
| Thiratmatrakul, S | 1 |
| Yenjai, C | 1 |
| Waiwut, P | 1 |
| Vajragupta, O | 3 |
| Reubroycharoen, P | 1 |
| Tohda, M | 1 |
| Boonyarat, C | 2 |
| Najafi, Z | 1 |
| Mahdavi, M | 1 |
| Saeedi, M | 1 |
| Karimpour-Razkenari, E | 1 |
| Asatouri, R | 1 |
| Vafadarnejad, F | 1 |
| Moghadam, FH | 1 |
| Khanavi, M | 1 |
| Sharifzadeh, M | 1 |
| Akbarzadeh, T | 1 |
| Ishola, IO | 2 |
| Tota, S | 2 |
| Adeyemi, OO | 2 |
| Agbaje, EO | 2 |
| Narender, T | 1 |
| Shukla, R | 2 |
| Mishra, A | 1 |
| Goel, RK | 1 |
| Xia, Y | 1 |
| Liu, R | 1 |
| Chen, R | 1 |
| Tian, Q | 1 |
| Zeng, K | 1 |
| Hu, J | 2 |
| Liu, X | 1 |
| Wang, Q | 4 |
| Wang, P | 2 |
| Wang, XC | 1 |
| Wang, JZ | 1 |
| Arunrungvichian, K | 1 |
| Fokin, VV | 1 |
| Taylor, P | 1 |
| Jiang, L | 1 |
| Huang, M | 1 |
| Xu, S | 2 |
| Wang, Y | 2 |
| An, P | 1 |
| Feng, C | 1 |
| Chen, X | 1 |
| Wei, X | 1 |
| Han, Y | 2 |
| Chang, L | 1 |
| Cui, W | 2 |
| Yang, Y | 1 |
| Zhou, W | 1 |
| Fu, H | 1 |
| Hu, S | 1 |
| Mak, S | 1 |
| Ma, VP | 1 |
| Choi, TC | 1 |
| Ma, ED | 1 |
| Tao, L | 1 |
| Pang, Y | 1 |
| Rowan, MJ | 1 |
| Anwyl, R | 1 |
| Hu, SQ | 2 |
| Wang, R | 2 |
| Mak, SH | 1 |
| Li, G | 1 |
| Hu, YJ | 1 |
| Lee, MY | 1 |
| Pang, YP | 1 |
| Han, YF | 2 |
| Zhu, X | 1 |
| Tian, J | 1 |
| Sun, S | 1 |
| Dong, Q | 1 |
| Zhang, F | 1 |
| Zhang, X | 1 |
| Hu, Y | 1 |
| Wang, Z | 1 |
| Zhang, R | 1 |
| Wu, P | 1 |
| Xia, Z | 1 |
| Orsi, A | 1 |
| Rees, D | 1 |
| Lee, IA | 1 |
| Joh, EH | 1 |
| Kim, DH | 2 |
| Saxena, G | 2 |
| Patro, IK | 1 |
| Nath, C | 2 |
| Cheng, LL | 1 |
| Chen, XN | 1 |
| Yu, L | 1 |
| Kuang, X | 1 |
| Wang, LL | 1 |
| Yang, W | 1 |
| Du, JR | 1 |
| Zhao, Q | 1 |
| Matsumoto, K | 2 |
| Tsuneyama, K | 1 |
| Tanaka, K | 1 |
| Li, F | 1 |
| Shibahara, N | 1 |
| Miyata, T | 1 |
| Yokozawa, T | 1 |
| Han, RW | 1 |
| Zhang, RS | 1 |
| Chang, M | 1 |
| Peng, YL | 1 |
| Choi, CL | 1 |
| Yin, M | 1 |
| Mishima, K | 1 |
| Egashira, N | 1 |
| Matsumoto, Y | 1 |
| Iwasaki, K | 1 |
| Fujiwara, M | 1 |
| Boonchoong, P | 1 |
| Sumanont, Y | 1 |
| Watanabe, H | 2 |
| Wongkrajang, Y | 1 |
| Kammasud, N | 1 |
| Rispoli, V | 1 |
| Rotiroti, D | 1 |
| Carelli, V | 1 |
| Liberatore, F | 1 |
| Scipione, L | 1 |
| Marra, R | 1 |
| Giorgioni, G | 1 |
| Di Stefano, A | 1 |
| Sabolek, HR | 2 |
| Bunce, JG | 2 |
| Giuliana, D | 1 |
| Chrobak, JJ | 2 |
| Yamamoto, Y | 1 |
| Mikami, A | 1 |
| Fujii, Y | 1 |
| Kamei, C | 2 |
| Yoon, BH | 1 |
| Kim, YW | 1 |
| Lee, S | 1 |
| Shin, BY | 1 |
| Jung, JW | 1 |
| Kim, HJ | 1 |
| Lee, YS | 1 |
| Choi, JS | 1 |
| Kim, SY | 1 |
| Lee, KT | 1 |
| Ryu, JH | 1 |
| Singh, SP | 1 |
| Agrawal, R | 1 |
| Brinkman, SD | 1 |
| Gershon, S | 1 |
| Burov, IuV | 1 |
| Baĭmanov, TD | 1 |
| Robakidze, TN | 1 |
| Murai, S | 1 |
| Saito, H | 1 |
| Abe, E | 1 |
| Masuda, Y | 1 |
| Odashima, J | 1 |
| Itoh, T | 1 |
| O'Connell, A | 1 |
| Earley, B | 1 |
| Leonard, BE | 1 |
| Eguchi, J | 1 |
| Yuasa, T | 1 |
| Egawa, M | 1 |
| Tobe, A | 1 |
| Kumar, V | 1 |
| Goldstein, MZ | 1 |
| Doraiswamy, PM | 1 |
| Senda, T | 1 |
| Matsuno, K | 1 |
| Okamoto, K | 1 |
| Kobayashi, T | 1 |
| Nakata, K | 1 |
| Mita, S | 1 |
| Abe, K | 1 |
| Horiuchi, M | 1 |
| Yoshimura, K | 1 |
| Murakami, Y | 1 |
| Tanaka, E | 1 |
| Sakai, Y | 1 |
| Li, HB | 1 |
| O'Neill, J | 1 |
| Fitten, LJ | 1 |
| Siembieda, D | 1 |
| Halgren, E | 1 |
| Kim, E | 1 |
| Fisher, A | 1 |
| Perryman, K | 1 |
| Devi, G | 1 |
| Silver, J | 1 |
| Chen, Z | 2 |
| Chen, JQ | 1 |
| Xu, AJ | 1 |
| Li, R | 1 |
| Wei, EQ | 1 |
| Nabeshima, T | 1 |
| Maruyama, E | 1 |
| Katoh, A | 1 |
| Kameyama, T | 1 |
| Volger, BW | 1 |
| Riekkinen, P | 2 |
| Sirviö, J | 1 |
4 reviews available for tacrine and Age-Related Memory Disorders
| Article | Year |
|---|---|
Measurement of cholinergic drug effects on memory in Alzheimer's disease.
Topics: Alzheimer Disease; Arecoline; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Humans | 1983 |
Advances in pharmacotherapy for decline of memory and cognition in patients with Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Cognition Disorders; Humans; Memory Disorders | 1996 |
Approaches to memory loss in neuropsychiatric disorders.
Topics: Aging; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholinesterase Inhibitors; Dementia; D | 2000 |
Alternatives in the treatment of memory loss in patients with Alzheimer's disease.
Topics: Alzheimer Disease; Humans; Memory Disorders; Multicenter Studies as Topic; Phosphatidylcholines; Phy | 1991 |
2 trials available for tacrine and Age-Related Memory Disorders
| Article | Year |
|---|---|
Measurement of cholinergic drug effects on memory in Alzheimer's disease.
Topics: Alzheimer Disease; Arecoline; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Humans | 1983 |
Alternatives in the treatment of memory loss in patients with Alzheimer's disease.
Topics: Alzheimer Disease; Humans; Memory Disorders; Multicenter Studies as Topic; Phosphatidylcholines; Phy | 1991 |
38 other studies available for tacrine and Age-Related Memory Disorders
| Article | Year |
|---|---|
Central cholinergic agents. 6. Synthesis and evaluation of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepi n-8-yl)-1-propanones and their analogs as central selective acetylcholinesterase inhibitors.
Topics: Animals; Behavior, Animal; Benzazepines; Cholinesterase Inhibitors; Diazepam; In Vitro Techniques; M | 1994 |
Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Butyrylcholin | 2014 |
Novel tacrine-1,2,3-triazole hybrids: In vitro, in vivo biological evaluation and docking study of cholinesterase inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Death; Cell Line; Cell | 2017 |
Protective effect of Cnestis ferruginea and its active constituent on scopolamine-induced memory impairment in mice: a behavioral and biochemical study.
Topics: Acetylcholinesterase; Administration, Oral; Animals; Antioxidants; Avoidance Learning; Biflavonoids; | 2013 |
Adjuvant anticholinesterase therapy for the management of epilepsy-induced memory deficit: a critical pre-clinical study.
Topics: Animals; Anticonvulsants; Atropine; Chemotherapy, Adjuvant; Cholinesterase Inhibitors; Epilepsy; Mal | 2014 |
Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats.
Topics: Animals; Brain Diseases; Calcium Channel Blockers; Cholinesterase Inhibitors; Disease Models, Animal | 2014 |
Cognitive improvements in a mouse model with substituted 1,2,3-triazole agonists for nicotinic acetylcholine receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; Cholinester | 2015 |
Bis(propyl)-cognitin Prevents β-amyloid-induced Memory Deficits as Well as Synaptic Formation and Plasticity Impairments via the Activation of PI3-K Pathway.
Topics: Amyloid beta-Peptides; Animals; Cognition Disorders; Dendrites; Hippocampus; Long-Term Potentiation; | 2016 |
Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Cells, Cultured; Cholineste | 2015 |
Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's β-Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Cell Survival; Disease | 2015 |
(-)-SCR1693 Protects against Memory Impairment and Hippocampal Damage in a Chronic Cerebral Hypoperfusion Rat Model.
Topics: Animals; Arterial Occlusive Diseases; Carotid Artery Diseases; Cerebrovascular Disorders; Chronic Di | 2016 |
Regulation of M1-receptor mRNA stability by smilagenin and its significance in improving memory of aged rats.
Topics: 3,3'-Diaminobenzidine; Aging; Analysis of Variance; Animals; Atropine; Binding Sites; Binding, Compe | 2010 |
Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice.
Topics: Acetylcholinesterase; Animals; Arctium; Avoidance Learning; Cholinesterase Inhibitors; Drugs, Chines | 2011 |
ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor.
Topics: Analysis of Variance; Animals; Blood Glucose; Brain; Calcium; Caspase 3; Cell Death; Cholinesterase | 2011 |
Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice.
Topics: 4-Butyrolactone; Acetylcholinesterase; Angelica; Animals; Choline O-Acetyltransferase; Cholinergic A | 2011 |
Diabetes-induced central cholinergic neuronal loss and cognitive deficit are attenuated by tacrine and a Chinese herbal prescription, kangen-karyu: elucidation in type 2 diabetes db/db mice.
Topics: Animals; Brain; Cholinergic Neurons; Cognition Disorders; Diabetes Mellitus, Experimental; Diabetes | 2011 |
Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins.
Topics: Analysis of Variance; Animals; Cholinergic Antagonists; Cholinesterase Inhibitors; Disease Models, A | 2012 |
Combretum mucronatum and Capparis thonningii prevent scopolamine-induced memory deficit in mice.
Topics: Administration, Oral; Animals; Antioxidants; Avoidance Learning; Brain; Capparis; Cholinesterase Inh | 2013 |
Involvement of reduced acetylcholine release in Delta9-tetrahydrocannabinol-induced impairment of spatial memory in the 8-arm radial maze.
Topics: Acetylcholine; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Cognition Disorders; Dronabinol; | 2002 |
Manganese-based complexes of radical scavengers as neuroprotective agents.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Dopamine; Flavonoids; Free Radical Scavengers; In Vitr | 2003 |
Choline pivaloyl esters improve in rats cognitive and memory performances impaired by scopolamine treatment or lesions of the nucleus basalis of Meynert.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Basal Nucleus of Meynert; Cell Count; Choline; | 2004 |
Within-subject memory decline in middle-aged rats: effects of intraseptal tacrine.
Topics: Acetylcholine; Aging; Animals; Catheterization; Cholinergic Fibers; Drug Administration Routes; Earl | 2004 |
Intraseptal tacrine-induced disruptions of spatial memory performance.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Discrimination Learning; | 2005 |
Effect of histamine on muscimol-induced working memory deficits in radial maze performance.
Topics: Animals; Brain Chemistry; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; GA | 2007 |
The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice.
Topics: Administration, Oral; Animals; Avoidance Learning; Behavior, Animal; Cassia; Cholinesterase Inhibito | 2007 |
Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Brain; Dementia; Disease Models, Animal; Donepezi | 2008 |
[The effect of amiridine and tacrine on reversible capture of neuromediators in experimental memory disorders].
Topics: Aminoquinolines; Animals; Biogenic Monoamines; Cholinesterase Inhibitors; Disease Models, Animal; Ma | 1995 |
MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice.
Topics: Acetylcholine; Acetylcholinesterase; Amnesia; Animals; Aziridines; Choline; Choline Deficiency; Data | 1994 |
The neuroprotective effect of tacrine on trimethyltin induced memory and muscarinic receptor dysfunction in the rat.
Topics: Amino Acid Transport Systems, Neutral; Animals; Autoradiography; Behavior, Animal; Brain; Carrier Pr | 1994 |
Effects of a novel compound MCI-225 on impaired learning and memory in rats.
Topics: Animals; Avoidance Learning; Behavior, Animal; Carbon Dioxide; Cholinesterase Inhibitors; Learning D | 1994 |
Ameliorating effect of SA4503, a novel sigma 1 receptor agonist, on memory impairments induced by cholinergic dysfunction in rats.
Topics: Animals; Avoidance Learning; Guinea Pigs; Ibotenic Acid; Male; Memory; Memory Disorders; Nootropic A | 1996 |
Potentiation by DSP-4 of EEG slowing and memory impairment in basal forebrain-lesioned rats.
Topics: Animals; Benzylamines; Brain Diseases; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Drug | 1997 |
Tacrine improves working memory deficit caused by permanent occlusion of bilateral common carotid arteries in rats.
Topics: Animals; Carotid Artery, Common; Carotid Stenosis; Cholinesterase Inhibitors; Disease Models, Animal | 1997 |
Effects of AF102B and tacrine on delayed match-to-sample in monkeys.
Topics: Age Factors; Animals; Humans; Macaca radiata; Memory; Memory Disorders; Parasympathomimetics; Quinuc | 1998 |
Effect of H1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats.
Topics: Animals; Cognition; Dibenzazepines; Diphenhydramine; Histamine H1 Antagonists; Imidazoles; Male; Maz | 2001 |
Reversal of scopolamine-induced spatial memory deficits in rats by TAK-147.
Topics: Animals; Benzazepines; Cholinesterase Inhibitors; Donepezil; Indans; Male; Maze Learning; Memory Dis | 2002 |
The effect of tacrine (THA) on cycloheximide- and basal forebrain lesion-induced memory deficit in rats.
Topics: Administration, Oral; Amnesia; Animals; Aphasia; Ataxia; Avoidance Learning; Behavior, Animal; Brain | 1991 |
The effects of THA on medial septal lesion-induced memory defects.
Topics: Aminoacridines; Animals; Avoidance Learning; Hippocampus; Male; Medial Forebrain Bundle; Memory; Mem | 1990 |