Page last updated: 2024-10-21

tacrine and Ache

tacrine has been researched along with Ache in 3 studies

Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.

Research Excerpts

ExcerptRelevanceReference
"We conclude that brain AChE inhibition by THA is sufficient to explain its purported therapeutic activity in Alzheimer's disease and that its favorable brain/plasma distribution in vivo may account for its central cholinergic action without inducing the severe peripheral cholinergic effects typically seen with other AChE inhibitors."1.28Correlation of brain levels of 9-amino-1,2,3,4-tetrahydroacridine (THA) with neurochemical and behavioral changes. ( Liston, D; Mena, EE; Nielsen, JA; Nocerini, MR; Williams, IH, 1989)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Matias, M1
Silvestre, S1
Falcao, A1
Alves, G1
Hooten, WM1
Pearlson, G1
Nielsen, JA1
Mena, EE1
Williams, IH1
Nocerini, MR1
Liston, D1

Reviews

1 review available for tacrine and Ache

ArticleYear
Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders.
    Mini reviews in medicinal chemistry, 2017, Volume: 17, Issue:6

    Topics: Analgesics; Central Nervous System Diseases; Choline; Donepezil; Epilepsy; gamma-Aminobutyric Acid;

2017

Other Studies

2 other studies available for tacrine and Ache

ArticleYear
Delirium caused by tacrine and ibuprofen interaction.
    The American journal of psychiatry, 1996, Volume: 153, Issue:6

    Topics: Aged; Alzheimer Disease; Delirium; Dose-Response Relationship, Drug; Drug Interactions; Female; Huma

1996
Correlation of brain levels of 9-amino-1,2,3,4-tetrahydroacridine (THA) with neurochemical and behavioral changes.
    European journal of pharmacology, 1989, Nov-28, Volume: 173, Issue:1

    Topics: Acetylcholinesterase; Aminoacridines; Animals; Avoidance Learning; Behavior, Animal; Brain; Brain Ch

1989