tacrine has been researched along with Ache in 3 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conclude that brain AChE inhibition by THA is sufficient to explain its purported therapeutic activity in Alzheimer's disease and that its favorable brain/plasma distribution in vivo may account for its central cholinergic action without inducing the severe peripheral cholinergic effects typically seen with other AChE inhibitors." | 1.28 | Correlation of brain levels of 9-amino-1,2,3,4-tetrahydroacridine (THA) with neurochemical and behavioral changes. ( Liston, D; Mena, EE; Nielsen, JA; Nocerini, MR; Williams, IH, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matias, M | 1 |
| Silvestre, S | 1 |
| Falcao, A | 1 |
| Alves, G | 1 |
| Hooten, WM | 1 |
| Pearlson, G | 1 |
| Nielsen, JA | 1 |
| Mena, EE | 1 |
| Williams, IH | 1 |
| Nocerini, MR | 1 |
| Liston, D | 1 |
1 review available for tacrine and Ache
| Article | Year |
|---|---|
Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders.
Topics: Analgesics; Central Nervous System Diseases; Choline; Donepezil; Epilepsy; gamma-Aminobutyric Acid; | 2017 |
2 other studies available for tacrine and Ache
| Article | Year |
|---|---|
Delirium caused by tacrine and ibuprofen interaction.
Topics: Aged; Alzheimer Disease; Delirium; Dose-Response Relationship, Drug; Drug Interactions; Female; Huma | 1996 |
Correlation of brain levels of 9-amino-1,2,3,4-tetrahydroacridine (THA) with neurochemical and behavioral changes.
Topics: Acetylcholinesterase; Aminoacridines; Animals; Avoidance Learning; Behavior, Animal; Brain; Brain Ch | 1989 |