tacrine has been researched along with Abnormalities, Autosome in 3 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tacrine was mutagenic in Salmonella but did not produce chromosome damage in CHO cells or in mouse bone marrow cells." | 1.30 | Genetic toxicity studies of 1,2,3,4-tetrahydro-9-acridinamine (tacrine). ( Erexson, G; Mortelmans, K; Thilagar, A; Zeiger, E, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zeiger, E | 1 |
| Erexson, G | 1 |
| Mortelmans, K | 1 |
| Thilagar, A | 1 |
| Giri, AK | 1 |
| Khan, KA | 1 |
| Srivastava, SK | 1 |
| Srivastava, RC | 1 |
| Sethi, N | 1 |
| Jarema, M | 1 |
1 review available for tacrine and Abnormalities, Autosome
| Article | Year |
|---|---|
[Progress in the studies of the etiology and treatment of Alzheimer's disease].
Topics: Acetylcholine; Alzheimer Disease; Brain; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Do | 1988 |
2 other studies available for tacrine and Abnormalities, Autosome
| Article | Year |
|---|---|
Genetic toxicity studies of 1,2,3,4-tetrahydro-9-acridinamine (tacrine).
Topics: Animals; Bone Marrow Cells; CHO Cells; Cholinesterase Inhibitors; Chromosome Aberrations; Cricetinae | 1997 |
Evaluation of the genotoxicity of 4-N-butylamino-1,2,3,4-tetrahydroacridine hydrochloride (centbucridine): a new local anaesthetic.
Topics: Anesthetics, Local; Animals; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; DNA Damage; Dos | 1992 |