t140-peptide and Lung-Neoplasms

t140-peptide has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for t140-peptide and Lung-Neoplasms

Article	Year
T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer. FEBS letters, 2003, Aug-28, Volume: 550, Issue:1-3 A chemokine receptor, CXCR4, and its endogenous ligand, stromal cell-derived factor-1 (SDF-1), have been recognized to be involved in the metastasis of several types of cancers. T140 analogs are peptidic CXCR4 antagonists composed of 14 amino acid residues that were previously developed as anti-HIV agents having inhibitory activity against HIV-entry through its co-receptor, CXCR4. Herein, we report that these compounds effectively inhibited SDF-1-induced migration of human breast cancer cells (MDA-MB-231), human leukemia T cells (Sup-T1) and human umbilical vein endothelial cells at concentrations of 10-100 nM in vitro. Furthermore, slow release administration by subcutaneous injection using an Alzet osmotic pump of a potent and bio-stable T140 analog, 4F-benzoyl-TN14003, gave a partial, but statistically significant (P Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Movement; Chemokine CXCL12; Chemokines, CXC; Drug Screening Assays, Antitumor; Endothelium, Vascular; Female; Gene Expression Regulation, Neoplastic; Humans; Jurkat Cells; Lung Neoplasms; Mice; Mice, SCID; Neoplasm Metastasis; Oligopeptides; Peptides; Receptors, CCR7; Receptors, Chemokine; Receptors, CXCR4; RNA, Messenger; Tumor Cells, Cultured	2003

Article

Year

T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer.

FEBS letters, 2003, Aug-28, Volume: 550, Issue:1-3

A chemokine receptor, CXCR4, and its endogenous ligand, stromal cell-derived factor-1 (SDF-1), have been recognized to be involved in the metastasis of several types of cancers. T140 analogs are peptidic CXCR4 antagonists composed of 14 amino acid residues that were previously developed as anti-HIV agents having inhibitory activity against HIV-entry through its co-receptor, CXCR4. Herein, we report that these compounds effectively inhibited SDF-1-induced migration of human breast cancer cells (MDA-MB-231), human leukemia T cells (Sup-T1) and human umbilical vein endothelial cells at concentrations of 10-100 nM in vitro. Furthermore, slow release administration by subcutaneous injection using an Alzet osmotic pump of a potent and bio-stable T140 analog, 4F-benzoyl-TN14003, gave a partial, but statistically significant (P

Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Movement; Chemokine CXCL12; Chemokines, CXC; Drug Screening Assays, Antitumor; Endothelium, Vascular; Female; Gene Expression Regulation, Neoplastic; Humans; Jurkat Cells; Lung Neoplasms; Mice; Mice, SCID; Neoplasm Metastasis; Oligopeptides; Peptides; Receptors, CCR7; Receptors, Chemokine; Receptors, CXCR4; RNA, Messenger; Tumor Cells, Cultured

2003