t0901317 has been researched along with Subarachnoid-Hemorrhage* in 1 studies
1 other study(ies) available for t0901317 and Subarachnoid-Hemorrhage
| Article | Year |
|---|---|
T0901317, an Agonist of Liver X Receptors, Attenuates Neuronal Apoptosis in Early Brain Injury after Subarachnoid Hemorrhage in Rats via Liver X Receptors/Interferon Regulatory Factor/P53 Upregulated Modulator of Apoptosis/Dynamin-1-Like Protein Pathway.
Subarachnoid hemorrhage (SAH) models of Sprague-Dawley rats were established with perforation method. T0901317 was injected intraperitoneally 1-hour post-SAH. GSK2033, an inhibitor of LXRs, and interferon regulatory factor (IRF-1) CRISPR activation were injected intracerebroventricularly to evaluate potential signaling pathway. The severity of SAH, neurobehavior test in both short- and long-term and apoptosis was measured with Western blot and immunofluorescence staining.. Expression of LXR-. T0901317 attenuated neuronal apoptosis via LXRs/IRF-1/PUMA/Drp1 pathway in SAH rats. Topics: Animals; Apoptosis; Brain Injuries; Dynamin I; Humans; Hydrocarbons, Fluorinated; Liver X Receptors; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; Subarachnoid Hemorrhage; Sulfonamides | 2021 |