suramin has been researched along with Weight Loss in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Weight Loss: Decrease in existing BODY WEIGHT.
| Excerpt | Relevance | Reference |
|---|---|---|
| "At present there is no effective treatment for cachexia." | 5.29 | Suramin interferes with interleukin-6 receptor binding in vitro and inhibits colon-26-mediated experimental cancer cachexia in vivo. ( D'Alessandro, F; Fong, M; Freter, CE; Nordan, RP; Strassmann, G; Windsor, S, 1993) |
| "At present there is no effective treatment for cachexia." | 1.29 | Suramin interferes with interleukin-6 receptor binding in vitro and inhibits colon-26-mediated experimental cancer cachexia in vivo. ( D'Alessandro, F; Fong, M; Freter, CE; Nordan, RP; Strassmann, G; Windsor, S, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Strassmann, G | 1 |
| Fong, M | 1 |
| Freter, CE | 1 |
| Windsor, S | 1 |
| D'Alessandro, F | 1 |
| Nordan, RP | 1 |
1 other study available for suramin and Weight Loss
| Article | Year |
|---|---|
Suramin interferes with interleukin-6 receptor binding in vitro and inhibits colon-26-mediated experimental cancer cachexia in vivo.
Topics: Adenocarcinoma; Animals; Cachexia; Colonic Neoplasms; Humans; Interleukin-6; Liver; Male; Mice; Mice | 1993 |