suramin has been researched along with Vitreoretinopathy, Proliferative in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Vitreoretinopathy, Proliferative: Vitreoretinal membrane shrinkage or contraction secondary to the proliferation of primarily retinal pigment epithelial cells and glial cells, particularly fibrous astrocytes, followed by membrane formation. The formation of fibrillar collagen and cellular proliferation appear to be the basis for the contractile properties of the epiretinal and vitreous membranes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the inhibiting effects of suramin on FGF induced proliferation of cultured RPE cells and discuss the effects and mechanisms of suramin in the prevention of proliferative vitreoretinopathy (PVR)." | 3.73 | [The inhibiting effects of suramin on bFGF induced proliferation of cultured human RPE cells]. ( Huang, XK; Luo, Y; Tang, SB; Zhu, XB, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, XB | 1 |
| Tang, SB | 1 |
| Luo, Y | 1 |
| Huang, XK | 1 |
| de Souza, OF | 1 |
| Sakamoto, T | 1 |
| Kimura, H | 1 |
| Koda, RP | 1 |
| Gabrielian, K | 1 |
| Spee, C | 1 |
| Ryan, SJ | 1 |
2 other studies available for suramin and Vitreoretinopathy, Proliferative
| Article | Year |
|---|---|
[The inhibiting effects of suramin on bFGF induced proliferation of cultured human RPE cells].
Topics: Cell Proliferation; Cells, Cultured; Fibroblast Growth Factor 2; Humans; Pigment Epithelium of Eye; | 2005 |
Inhibition of experimental proliferative vitreoretinopathy in rabbits by suramin.
Topics: Animals; Antineoplastic Agents; Biological Availability; Cells, Cultured; Disease Models, Animal; Fi | 1995 |