suramin and Uveitis
suramin has been researched along with Uveitis in 3 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Uveitis: Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin treatment was most effective in suppressing EAU when started concurrently with immunization (afferent)." | 5.29 | Suramin treatment suppresses induction of experimental autoimmune uveoretinitis (EAU) in rodents. ( Caspi, RR; Chan, CC; Sartani, G; Silver, PB; Strassmann, G, 1995) |
| "Suramin treatment was most effective in suppressing EAU when started concurrently with immunization (afferent)." | 1.29 | Suramin treatment suppresses induction of experimental autoimmune uveoretinitis (EAU) in rodents. ( Caspi, RR; Chan, CC; Sartani, G; Silver, PB; Strassmann, G, 1995) |
Research
Studies (3)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Defontis, M | 1 |
| Richartz, J | 1 |
| Engelmann, N | 1 |
| Bauer, C | 1 |
| Schwierk, VM | 1 |
| Büscher, P | 1 |
| Moritz, A | 1 |
| Sartani, G | 1 |
| Silver, PB | 1 |
| Strassmann, G | 1 |
| Chan, CC | 1 |
| Caspi, RR | 1 |
| Vingtain, P | 1 |
| Lucot, J | 1 |
| Chovet, M | 1 |
Other Studies
3 other studies available for suramin and Uveitis
| Article | Year |
|---|---|
Canine Trypanosoma evansi infection introduced into Germany.
Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Anti-Inflammatory Age | 2012 |
Suramin treatment suppresses induction of experimental autoimmune uveoretinitis (EAU) in rodents.
Topics: Animals; Autoimmune Diseases; Eye Proteins; Female; Hypersensitivity, Delayed; Immunization; Immunog | 1995 |
[Therapy of ocular onchocerciasis].
Topics: Anthelmintics; Diethylcarbamazine; Eye Diseases; Filaricides; Humans; Keratitis; Onchocerciasis; Sur | 1979 |