Page last updated: 2024-11-04

suramin and Uveitis

suramin has been researched along with Uveitis in 3 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Uveitis: Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"Suramin treatment was most effective in suppressing EAU when started concurrently with immunization (afferent)."5.29Suramin treatment suppresses induction of experimental autoimmune uveoretinitis (EAU) in rodents. ( Caspi, RR; Chan, CC; Sartani, G; Silver, PB; Strassmann, G, 1995)
"Suramin treatment was most effective in suppressing EAU when started concurrently with immunization (afferent)."1.29Suramin treatment suppresses induction of experimental autoimmune uveoretinitis (EAU) in rodents. ( Caspi, RR; Chan, CC; Sartani, G; Silver, PB; Strassmann, G, 1995)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Defontis, M1
Richartz, J1
Engelmann, N1
Bauer, C1
Schwierk, VM1
Büscher, P1
Moritz, A1
Sartani, G1
Silver, PB1
Strassmann, G1
Chan, CC1
Caspi, RR1
Vingtain, P1
Lucot, J1
Chovet, M1

Other Studies

3 other studies available for suramin and Uveitis

ArticleYear
Canine Trypanosoma evansi infection introduced into Germany.
    Veterinary clinical pathology, 2012, Volume: 41, Issue:3

    Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Anti-Inflammatory Age

2012
Suramin treatment suppresses induction of experimental autoimmune uveoretinitis (EAU) in rodents.
    Current eye research, 1995, Volume: 14, Issue:10

    Topics: Animals; Autoimmune Diseases; Eye Proteins; Female; Hypersensitivity, Delayed; Immunization; Immunog

1995
[Therapy of ocular onchocerciasis].
    Revue internationale du trachome et de pathologie oculaire tropicale et subtropicale : organe de la Ligue contre le trachome avec la collaboration de l'International Organization against Trachoma et des organisations nationales et inter..., 1979, Volume: 56, Issue:3-4

    Topics: Anthelmintics; Diethylcarbamazine; Eye Diseases; Filaricides; Humans; Keratitis; Onchocerciasis; Sur

1979