suramin has been researched along with Ureteral Obstruction in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Ureteral Obstruction: Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We recently showed that suramin treatment prevents the onset of renal fibrosis in a model of obstructive nephropathy induced by unilateral ureteral obstruction (UUO)." | 7.77 | Delayed administration of suramin attenuates the progression of renal fibrosis in obstructive nephropathy. ( Liu, N; Ponnusamy, M; Tolbert, E; Yan, H; Zhuang, S, 2011) |
| "We recently showed that suramin treatment prevents the onset of renal fibrosis in a model of obstructive nephropathy induced by unilateral ureteral obstruction (UUO)." | 3.77 | Delayed administration of suramin attenuates the progression of renal fibrosis in obstructive nephropathy. ( Liu, N; Ponnusamy, M; Tolbert, E; Yan, H; Zhuang, S, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, N | 1 |
| Tolbert, E | 1 |
| Ponnusamy, M | 1 |
| Yan, H | 1 |
| Zhuang, S | 1 |
1 other study available for suramin and Ureteral Obstruction
| Article | Year |
|---|---|
Delayed administration of suramin attenuates the progression of renal fibrosis in obstructive nephropathy.
Topics: Actins; Animals; Blotting, Western; Cells, Cultured; Collagen Type I; Disease Progression; ErbB Rece | 2011 |