suramin has been researched along with Trypanosomiasis, African in 164 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin was the first drug developed using the approach of medicinal chemistry by the German Bayer company in the 1910s for the treatment of human African sleeping sickness caused by the two subspecies Trypanosoma brucei gambiense and Trypanosoma brucei rhodesienese." | 5.41 | 100 years since the publication of the suramin formula. ( Steverding, D; Troeberg, L, 2023) |
| "Suramin is one of the first drugs developed in a medicinal chemistry program (Bayer, 1916), and it is still the treatment of choice for the hemolymphatic stage of African sleeping sickness caused by Trypanosoma brucei rhodesiense." | 3.88 | Beyond immune escape: a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei. ( Cal, M; Graf, FE; Kunz Renggli, C; Mäser, P; Ndomba, E; Schmidt, RS; Wenzler, T; Wiedemar, N; Zwyer, M, 2018) |
| " He presented with an inoculation chancre and was treated with suramin within four days of fever onset." | 3.78 | Human African trypanosomiasis in a Belgian traveller returning from the Masai Mara area, Kenya, February 2012. ( Asselman, V; Clerinx, J; Lejon, V; Maes, MB; Van de Casteele, S; Vlieghe, E, 2012) |
| "Human African trypanosomiasis (HAT), otherwise known as sleeping sickness, has remained a disease with no effective treatment." | 2.42 | Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis. ( Nok, AJ, 2003) |
| "Human African trypanosomiasis is a fatal disease caused by Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense that has re-emerged in recent years." | 2.42 | Current chemotherapy of human African trypanosomiasis. ( Docampo, R; Moreno, SN, 2003) |
| "Suramin has been a primary early-stage treatment for African trypanosomiasis for nearly 100 yr." | 1.62 | Structure of trypanosome coat protein VSGsur and function in suramin resistance. ( Hälg, S; Hashemi, H; Hempelmann, A; Jeffrey, PD; Mäser, P; Papavasiliou, FN; Perez, K; Stebbins, CE; van Straaten, M; Verdi, J; Wiedemar, N; Zeelen, J, 2021) |
| "Suramin treatment failures has been observed among HAT patients in Tbr foci in Uganda." | 1.62 | Physiological and proteomic profiles of Trypanosoma brucei rhodesiense parasite isolated from suramin responsive and non-responsive HAT patients in Busoga, Uganda. ( Adung'a, VO; Akoth, MO; Awuoche, EO; Bateta, R; Mang'era, CM; Mireji, PO; Mutuku, CN; Ndung'u, K; Njunge, JM; Ondigo, BN; Rono, MK, 2021) |
| "We present a case of East-African trypanosomiasis (EAT) in a 56-year-old Dutch woman returning from holiday in Tanzania and Kenya." | 1.48 | A case of delayed diagnosis of East-African trypanosomiasis in a Dutch traveller. ( Hanssen, JLJ; Scheper, H; van Lieshout, L; Visser, LG; Wijsman, CA, 2018) |
| "Human African trypanosomiasis (HAT) is one of the most complex parasitic diseases known to humankind." | 1.48 | Trypanosoma brucei rhodesiense infection in a Chinese traveler returning from the Serengeti National Park in Tanzania. ( Chen, JX; Chen, MX; Chen, XL; Chen, ZY; Lin, YY; Liu, Q; Xie, HG; Zhang, Y; Zheng, H; Zhou, XN, 2018) |
| "Human African trypanosomiasis is a fatal parasitic infection caused by the protozoan Trypanosoma brucei." | 1.40 | Novel pyrrolobenzoxaboroles: design, synthesis, and biological evaluation against Trypanosoma brucei. ( Jacobs, RT; Meng, Q; Nare, B; Wu, P; Zhang, J; Zhou, H, 2014) |
| "African trypanosomiasis is a neglected tropical disease affecting humans and animals across 36 sub-Saharan African countries." | 1.39 | Investigating mammalian tyrosine phosphatase inhibitors as potential 'piggyback' leads to target Trypanosoma brucei transmission. ( Clark, R; Matthews, KR; Ruberto, I; Szoor, B, 2013) |
| "In January 2012, a case of Human African Trypanosomiasis (HAT) has been identified in Germany in a traveller returning from the Masai Mara area in Kenya." | 1.38 | Trypanosoma brucei rhodesiense infection in a German traveller returning from the Masai Mara area, Kenya, January 2012. ( Brodt, HR; Gottig, S; Just-Nuebling, G; Kleine, C; Wichelhaus, T; Wolf, T, 2012) |
| "Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa." | 1.36 | Human African trypanosomiasis. ( Blum, J; Brun, R; Burri, C; Chappuis, F, 2010) |
| "During the first stage of human African trypanosomiasis (HAT), Trypanosoma brucei gambiense is found mainly in the blood, and pentamidine treatment is used." | 1.35 | Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein. ( De Koning, HP; Dogruel, M; Rodgers, J; Sanderson, L; Thomas, SA, 2009) |
| "Sleeping sickness (human African trypanosomiasis) is a parasitic infection transmitted by day-biting tsetse flies." | 1.34 | African trypanosomiasis in a British soldier. ( Croft, AM; Friend, HM; Jackson, CJ; Kitson, MM; Minton, EJ, 2007) |
| "Relapses were significantly correlated with intrathecal IgM synthesis (odds ratio [OR], 46; 95% confidence interval [CI], 8 to 260), a CSF IgM concentration of >or=1." | 1.34 | Treatment failure related to intrathecal immunoglobulin M (IgM) synthesis, cerebrospinal fluid IgM, and interleukin-10 in patients with hemolymphatic-stage sleeping sickness. ( Bisser, S; Boelaert, M; Büscher, P; Hoogstoel, A; Lejon, V; Mumba, D; N'Siesi, FX; Reiber, H; Robays, J, 2007) |
| "We postulate that he had a transverse myelitis due to African trypanosomiasis, a rare and barely recognised cause." | 1.33 | Transverse myelitis due to trypanosomiasis in a middle aged Tanzanian man. ( Kibiki, GS; Murphy, DK, 2006) |
| "Human African trypanosomiasis (sleeping sickness) is a parasitic infection transmitted by day-biting tsetse flies." | 1.33 | African trypanosomiasis in a British soldier. ( Croft, AM; Friend, HM; Jackson, CJ; Minton, EJ, 2006) |
| "African trypanosomiasis is a re-emerging disease." | 1.33 | Orchitis as an unusual manifestation of human African trypanosomiasis. ( Burchard, GD; Ehrhardt, S; Lippert, U; Sudeck, H, 2006) |
| "In human African trypanosomiasis (HAT), the parasites invade the central nervous system (CNS), leading to the development of meningo-encephalitis and an irreversible demyelinating process, which kills the patient unless specific treatment is undertaken." | 1.32 | Megazol combined with suramin improves a new diagnosis index of the early meningo-encephalitic phase of experimental African trypanosomiasis. ( Bourdon, L; Bouteille, B; Buguet, A; Chevrier, C; Darsaud, A; Dumas, M, 2004) |
| "Treatment of late-stage human African trypanosomiasis is complicated by the presence of trypanosomes within the central nervous system (CNS)." | 1.31 | Human African trypanosomiasis: potential therapeutic benefits of an alternative suramin and melarsoprol regimen. ( Bradley, B; Gettinby, G; Jennings, FW; Kennedy, PG; Murray, M; Rodgers, J, 2002) |
| "Human African Trypanosomiasis (HAT) is a re-emerging disease whose usual treatments are becoming less efficient because of the increasing parasite resistance." | 1.31 | Availability and affordability of treatment for Human African Trypanosomiasis. ( Etchegorry, MG; Helenport, JP; Jannin, J; Legros, D; Pecoul, B, 2001) |
| "Two returning safari tourists with African trypanosomiasis were admitted to the Hospital for Tropical Diseases, London, in a 3-day period, compared with six cases in the previous 14 years." | 1.31 | African trypanosomiasis in travelers returning to the United Kingdom. ( Agranoff, D; Bailey, JW; Chiodini, PL; Edwards, M; Escombe, R; Moore, DA; Squire, SB, 2002) |
| "This year at least nine cases of African trypanosomiasis have occurred among Europeans visiting the Serengeti Park in Tanzania." | 1.31 | [African trypanosomiasis--a rare imported disease]. ( Myrvang, B; von der Lippe, B, 2002) |
| "Chemotherapy for human African trypanosomiasis (HAT), or sleeping sickness, is unreliable because of resistance, refraction and toxic and adverse side-effects." | 1.30 | Megazol combined with suramin: a chemotherapy regimen which reversed the CNS pathology in a model of human African trypanosomiasis in mice. ( Bouteille, B; Chauvière, G; Dumas, M; Enanga, B; Keita, M, 1998) |
| " Two other goats appeared to be cured with this dosage of suramin but later developed abnormal central nervous system (CNS) signs and parasitaemia." | 1.28 | Experimental infection of goats with Trypanosoma brucei ssp. and effects of treatment with suramin and Mel-B. ( Chumo, DA; Muriithi, RM; Mwangi, J; Reardon, MJ; Towett, S; Wellde, BT, 1989) |
| "Mel-B was used to treat 55 relapses after suramin therapy with 1." | 1.28 | Treatment of Rhodesian sleeping sickness in Kenya. ( Abinya, A; Chumo, DA; Dola, S; Mbwabi, D; Reardon, MJ; Siongok, TA; Smith, DH; Wanyama, L; Wellde, BT, 1989) |
| "An American citizen acquired African trypanosomiasis while on a hunting safari in Sudan, East Africa." | 1.27 | African trypanosomiasis in an American hunter in East Africa. ( Hill, CD; Quinn, TC, 1983) |
| " A (donor) mouse, infected for 28 days, is dosed with a drug, or combination of drugs, and samples of blood, cerebral cortex, choroid plexus and lining of ventricle are injected into clean (recipient) mice." | 1.27 | Screening compounds for sleeping sickness therapy without relapse. ( Ormerod, WE; Raseroka, BH, 1988) |
| " Both inhibitors cured the TREU 667 and LUMP 1001 isolates if used in combination with a single (20 mg/kg) injection of suramin, a trypanocide in current clinical use." | 1.27 | Effects of the ornithine decarboxylase inhibitors DL-alpha-difluoromethylornithine and alpha-monofluoromethyldehydroornithine methyl ester alone and in combination with suramin against Trypanosoma brucei brucei central nervous system models. ( Bacchi, CJ; Bienen, EJ; Bitonti, AJ; Clarkson, AB; McCann, PP; Nathan, HC; Sjoerdsma, A, 1987) |
| "Suramin was very effective, even after combined therapy had failed repeatedly, while melarsoprol was less effective." | 1.27 | Trypanosoma brucei and T. vivax: salicylhydroxamic acid and glycerol treatment of acute and chronically infected rats. ( van der Meer, C; Versluijs-Broers, JA, 1986) |
| "Since 1967, six cases of African trypanosomiasis have been diagnosed and treated in the United States." | 1.25 | Imported African trypanosomiasis in the United States. ( Brodsky, RE; Gibson, JJ; Schultz, MG; Spencer, HC, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 78 (47.56) | 18.7374 |
| 1990's | 23 (14.02) | 18.2507 |
| 2000's | 29 (17.68) | 29.6817 |
| 2010's | 29 (17.68) | 24.3611 |
| 2020's | 5 (3.05) | 2.80 |
| Authors | Studies |
|---|---|
| George, TG | 1 |
| Endeshaw, MM | 1 |
| Morgan, RE | 1 |
| Mahasenan, KV | 1 |
| Delfín, DA | 1 |
| Mukherjee, MS | 1 |
| Yakovich, AJ | 1 |
| Fotie, J | 1 |
| Li, C | 1 |
| Werbovetz, KA | 1 |
| Olmo, ED | 1 |
| Diaz-González, R | 1 |
| Escarcena, R | 1 |
| Carvalho, L | 1 |
| Bustos, LA | 1 |
| Navarro, M | 1 |
| Feliciano, AS | 1 |
| Ettari, R | 1 |
| Tamborini, L | 2 |
| Angelo, IC | 1 |
| Micale, N | 1 |
| Pinto, A | 2 |
| De Micheli, C | 2 |
| Conti, P | 2 |
| Wu, P | 1 |
| Zhang, J | 1 |
| Meng, Q | 1 |
| Nare, B | 1 |
| Jacobs, RT | 1 |
| Zhou, H | 1 |
| Seebacher, W | 1 |
| Wolkinger, V | 1 |
| Faist, J | 1 |
| Kaiser, M | 1 |
| Brun, R | 4 |
| Saf, R | 1 |
| Bucar, F | 1 |
| Gröblacher, B | 1 |
| Brantner, A | 1 |
| Merino, V | 1 |
| Kalia, Y | 1 |
| Scapozza, L | 1 |
| Perozzo, R | 1 |
| Weis, R | 1 |
| Eadsforth, TC | 1 |
| Luciani, R | 1 |
| Cullia, G | 1 |
| Marinelli, L | 1 |
| Cosconati, S | 1 |
| Novellino, E | 1 |
| Lo Presti, L | 1 |
| Cordeiro da Silva, A | 1 |
| Hunter, WN | 1 |
| Costi, MP | 1 |
| Steverding, D | 2 |
| Troeberg, L | 1 |
| Wiedemar, N | 3 |
| Hauser, DA | 1 |
| Mäser, P | 3 |
| Ndung'u, K | 2 |
| Murilla, GA | 1 |
| Thuita, JK | 1 |
| Ngae, GN | 1 |
| Auma, JE | 1 |
| Gitonga, PK | 1 |
| Thungu, DK | 1 |
| Kurgat, RK | 1 |
| Chemuliti, JK | 1 |
| Mdachi, RE | 1 |
| Zeelen, J | 1 |
| van Straaten, M | 1 |
| Verdi, J | 1 |
| Hempelmann, A | 1 |
| Hashemi, H | 1 |
| Perez, K | 1 |
| Jeffrey, PD | 1 |
| Hälg, S | 1 |
| Papavasiliou, FN | 1 |
| Stebbins, CE | 1 |
| Mutuku, CN | 1 |
| Bateta, R | 1 |
| Rono, MK | 1 |
| Njunge, JM | 1 |
| Awuoche, EO | 1 |
| Mang'era, CM | 1 |
| Akoth, MO | 1 |
| Adung'a, VO | 1 |
| Ondigo, BN | 1 |
| Mireji, PO | 1 |
| Gómez-Junyent, J | 1 |
| Pinazo, MJ | 1 |
| Castro, P | 1 |
| Fernández, S | 1 |
| Mas, J | 1 |
| Chaguaceda, C | 1 |
| Pellicé, M | 1 |
| Gascón, J | 1 |
| Muñoz, J | 1 |
| Graf, FE | 1 |
| Zwyer, M | 1 |
| Ndomba, E | 1 |
| Kunz Renggli, C | 1 |
| Cal, M | 1 |
| Schmidt, RS | 1 |
| Wenzler, T | 1 |
| Wijsman, CA | 1 |
| Hanssen, JLJ | 1 |
| Scheper, H | 1 |
| Visser, LG | 1 |
| van Lieshout, L | 1 |
| Liu, Q | 2 |
| Chen, XL | 1 |
| Chen, MX | 1 |
| Xie, HG | 1 |
| Chen, ZY | 1 |
| Lin, YY | 1 |
| Zheng, H | 1 |
| Chen, JX | 1 |
| Zhang, Y | 1 |
| Zhou, XN | 1 |
| Kolosevska, K | 1 |
| Sánchez-Moreno, M | 1 |
| Huits, R | 1 |
| De Ganck, G | 1 |
| Clerinx, J | 2 |
| Büscher, P | 2 |
| Bottieau, E | 1 |
| Thomas, JA | 1 |
| Baker, N | 2 |
| Hutchinson, S | 1 |
| Dominicus, C | 1 |
| Trenaman, A | 1 |
| Glover, L | 2 |
| Alsford, S | 3 |
| Horn, D | 3 |
| Kennedy, PGE | 1 |
| Rodgers, J | 3 |
| Field, MC | 3 |
| Cnops, J | 1 |
| Bockstal, V | 1 |
| De Trez, C | 1 |
| Miquel, MC | 1 |
| Radwanska, M | 1 |
| Magez, S | 1 |
| Sbaraglini, ML | 1 |
| Vanrell, MC | 1 |
| Bellera, CL | 1 |
| Benaim, G | 1 |
| Carrillo, C | 1 |
| Talevi, A | 1 |
| Romano, PS | 1 |
| Hedley, L | 1 |
| Fink, D | 1 |
| Sparkes, D | 1 |
| Chiodini, PL | 4 |
| Sanderson, L | 1 |
| Dogruel, M | 1 |
| De Koning, HP | 2 |
| Thomas, SA | 1 |
| Ishiyama, A | 1 |
| Otoguro, K | 1 |
| Iwatsuki, M | 2 |
| Namatame, M | 1 |
| Nishihara, A | 1 |
| Nonaka, K | 1 |
| Kinoshita, Y | 1 |
| Takahashi, Y | 1 |
| Masuma, R | 1 |
| Shiomi, K | 1 |
| Yamada, H | 1 |
| Omura, S | 1 |
| Blum, J | 2 |
| Chappuis, F | 1 |
| Burri, C | 2 |
| Schlitzer, M | 1 |
| Nadjm, B | 1 |
| Van Tulleken, C | 1 |
| Macdonald, D | 1 |
| Wainwright, M | 1 |
| Jacobi, EA | 1 |
| Eckert, S | 1 |
| Sanchez-Flores, A | 1 |
| Leung, KF | 1 |
| Turner, DJ | 1 |
| Berriman, M | 1 |
| Cottle, LE | 1 |
| Peters, JR | 1 |
| Hall, A | 1 |
| Bailey, JW | 2 |
| Noyes, HA | 1 |
| Rimington, JE | 1 |
| Beeching, NJ | 1 |
| Squire, SB | 2 |
| Beadsworth, MB | 1 |
| Wolf, T | 1 |
| Wichelhaus, T | 1 |
| Gottig, S | 1 |
| Kleine, C | 1 |
| Brodt, HR | 1 |
| Just-Nuebling, G | 1 |
| Vlieghe, E | 1 |
| Asselman, V | 1 |
| Van de Casteele, S | 1 |
| Maes, MB | 1 |
| Lejon, V | 2 |
| Richter, J | 1 |
| Göbels, S | 1 |
| Göbel, T | 1 |
| Westenfeld, R | 1 |
| Müller-Stöver, I | 1 |
| Häussinger, D | 1 |
| Wise, E | 1 |
| Easom, N | 1 |
| Watson, J | 1 |
| Bailey, R | 1 |
| Brown, M | 1 |
| Kuepfer, I | 1 |
| Schmid, C | 2 |
| Allan, M | 1 |
| Edielu, A | 1 |
| Haary, EP | 1 |
| Kakembo, A | 1 |
| Kibona, S | 1 |
| Ruberto, I | 1 |
| Szoor, B | 1 |
| Clark, R | 1 |
| Matthews, KR | 1 |
| Jennings, FW | 12 |
| Bradley, B | 1 |
| Gettinby, G | 1 |
| Kennedy, PG | 1 |
| Murray, M | 1 |
| Kager, PA | 1 |
| Nok, AJ | 1 |
| Docampo, R | 1 |
| Moreno, SN | 1 |
| MASSEGUIN, A | 1 |
| CAUSSE, M | 1 |
| RICOSSE, M | 1 |
| WILLIAMSON, J | 7 |
| STEPHEN, LE | 2 |
| NEUJEAN, G | 1 |
| BERG, SS | 1 |
| BROWN, KN | 1 |
| LUCAS, JM | 1 |
| SCHNEIDER, J | 2 |
| CAHILL, KM | 1 |
| GILL, BS | 1 |
| MALHOTRA, MN | 1 |
| LIMBOS, P | 1 |
| JADIN, J | 1 |
| WALLS, LP | 1 |
| TELLA, A | 1 |
| Darsaud, A | 1 |
| Chevrier, C | 1 |
| Bourdon, L | 1 |
| Dumas, M | 4 |
| Buguet, A | 1 |
| Bouteille, B | 5 |
| Faust, SN | 1 |
| Woodrow, CJ | 1 |
| Patel, S | 1 |
| Snape, M | 1 |
| Tudor-Williams, G | 1 |
| Hermione Lyall, EG | 1 |
| Ehrhardt, S | 1 |
| Lippert, U | 1 |
| Burchard, GD | 1 |
| Sudeck, H | 1 |
| Kibona, SN | 1 |
| Matemba, L | 1 |
| Kaboya, JS | 1 |
| Lubega, GW | 1 |
| Tsuda, A | 1 |
| Witola, WH | 1 |
| Konnai, S | 1 |
| Ohashi, K | 1 |
| Onuma, M | 1 |
| Kibiki, GS | 1 |
| Murphy, DK | 1 |
| Uslan, DZ | 1 |
| Jacobson, KM | 1 |
| Kumar, N | 1 |
| Berbari, EF | 1 |
| Orenstein, R | 1 |
| Croft, AM | 2 |
| Jackson, CJ | 2 |
| Friend, HM | 2 |
| Minton, EJ | 2 |
| Robays, J | 1 |
| N'Siesi, FX | 1 |
| Mumba, D | 1 |
| Hoogstoel, A | 1 |
| Bisser, S | 1 |
| Reiber, H | 1 |
| Boelaert, M | 1 |
| Kitson, MM | 1 |
| Amin, DN | 1 |
| Masocha, W | 1 |
| Ngan'dwe, K | 1 |
| Rottenberg, M | 1 |
| Kristensson, K | 1 |
| Fairlamb, AH | 2 |
| Bowman, IB | 2 |
| Dukes, P | 1 |
| Clarkson, AB | 3 |
| Bienen, EJ | 2 |
| Bacchi, CJ | 3 |
| McCann, PP | 3 |
| Nathan, HC | 3 |
| Hutner, SH | 1 |
| Sjoerdsma, A | 3 |
| Urquhart, GM | 4 |
| Murray, PK | 2 |
| Miller, BM | 2 |
| Quinn, TC | 1 |
| Hill, CD | 1 |
| Emerole, GO | 1 |
| Thabrew, MI | 1 |
| Cochran, R | 1 |
| Rosen, T | 1 |
| Robertson, DH | 1 |
| Pickens, S | 1 |
| Lawson, JH | 1 |
| Lennox, B | 1 |
| Shertzer, HG | 1 |
| Hall, JE | 2 |
| Seed, JR | 2 |
| Otte, JA | 1 |
| Nouwen, JL | 1 |
| Wismans, PJ | 1 |
| Beukers, R | 1 |
| Vroon, HJ | 1 |
| Stuiver, PC | 1 |
| Doua, F | 1 |
| Boa Yapo, F | 1 |
| Yunmbam, MK | 1 |
| Roberts, JF | 1 |
| Burudi, EM | 1 |
| Karanja, SM | 1 |
| Njue, AI | 1 |
| Githiori, JB | 1 |
| Ndung'u, JM | 2 |
| Kinabo, LD | 1 |
| Kimata, DM | 1 |
| Makawiti, DW | 1 |
| Tengekyon, KM | 1 |
| Dadzie, S | 1 |
| Waindi, EN | 1 |
| Niederau, C | 1 |
| Günther, B | 1 |
| Erkenbrecht, J | 1 |
| Strohmeyer, G | 1 |
| Damian, MS | 1 |
| Dorndorf, W | 1 |
| Burkardt, H | 1 |
| Singer, I | 1 |
| Leinweber, B | 1 |
| Schachenmayr, W | 1 |
| Pépin, J | 1 |
| Milord, F | 1 |
| Yarlett, N | 1 |
| Goldberg, B | 1 |
| Saric, M | 1 |
| Iten, M | 1 |
| Matovu, E | 1 |
| Kaminsky, R | 4 |
| Keita, M | 2 |
| Enanga, B | 2 |
| Vallat, JM | 1 |
| Harrison, SM | 2 |
| Harris, RW | 1 |
| Bales, JD | 2 |
| El Sawalhy, A | 1 |
| El Attar, H | 1 |
| Chauvière, G | 1 |
| Pérez Martín, O | 1 |
| Lastre González, M | 1 |
| Urban, M | 1 |
| Shwalbach, J | 1 |
| El Rayah, IE | 1 |
| El Malik, KH | 1 |
| Malesker, MA | 1 |
| Boken, D | 1 |
| Ruma, TA | 1 |
| Vuchetich, PJ | 1 |
| Murphy, PJ | 1 |
| Smith, PW | 1 |
| Barrett, SV | 1 |
| Barrett, MP | 1 |
| Sanner, BM | 1 |
| Doberauer, C | 1 |
| Tepel, M | 1 |
| Zidek, W | 1 |
| Etchegorry, MG | 1 |
| Helenport, JP | 1 |
| Pecoul, B | 1 |
| Jannin, J | 1 |
| Legros, D | 1 |
| Moore, DA | 1 |
| Edwards, M | 1 |
| Escombe, R | 1 |
| Agranoff, D | 1 |
| Myrvang, B | 1 |
| von der Lippe, B | 1 |
| Moore, AC | 1 |
| Ryan, ET | 1 |
| Waldron, MA | 1 |
| Pal, A | 1 |
| Hall, BS | 1 |
| Recht, K | 1 |
| Pfürtner-Bloos, I | 1 |
| Gross, R | 1 |
| Spencer, HC | 1 |
| Gibson, JJ | 1 |
| Brodsky, RE | 1 |
| Schultz, MG | 2 |
| Foulkes, JR | 1 |
| Buyst, H | 2 |
| Olowe, SA | 1 |
| Jones, IG | 1 |
| Lowenthal, MN | 1 |
| Mahmoud, AA | 1 |
| Warren, KS | 1 |
| Zweygarth, E | 3 |
| Eckersall, PD | 1 |
| Webster, P | 1 |
| Demey, F | 1 |
| Ormerod, WE | 3 |
| Raseroka, BH | 3 |
| Mbwabi, DL | 1 |
| Schecter, PJ | 1 |
| Thomson, KD | 1 |
| Baeriswyl, S | 1 |
| Kunz, C | 1 |
| Wellde, BT | 2 |
| Reardon, MJ | 2 |
| Chumo, DA | 2 |
| Muriithi, RM | 1 |
| Towett, S | 1 |
| Mwangi, J | 1 |
| Abinya, A | 1 |
| Wanyama, L | 1 |
| Dola, S | 1 |
| Mbwabi, D | 1 |
| Smith, DH | 1 |
| Siongok, TA | 1 |
| Löscher, T | 1 |
| Nothdurft, HD | 1 |
| Taelman, H | 1 |
| Boogaerts, M | 1 |
| Omar, M | 1 |
| von Sonnenburg, F | 1 |
| Jefferies, D | 1 |
| Jenni, L | 1 |
| Waitumbi, JN | 1 |
| Brown, HC | 1 |
| Holmes, PH | 1 |
| Nieman, RE | 1 |
| Kelly, JJ | 1 |
| Waskin, HA | 1 |
| Bitonti, AJ | 1 |
| Ulrich, P | 1 |
| Cerami, A | 1 |
| Darde, ML | 1 |
| Pestre-Alexandre, M | 1 |
| Gutteridge, WE | 1 |
| Arroz, J | 1 |
| Djedje, M | 1 |
| de Diego, JA | 1 |
| Higueras, A | 1 |
| Gamallo, C | 1 |
| Mayer, RF | 1 |
| Rey Calero, J | 1 |
| Röttcher, D | 1 |
| van der Meer, C | 1 |
| Versluijs-Broers, JA | 1 |
| Gear, JH | 1 |
| Miller, GB | 1 |
| Weir, AB | 1 |
| Agbowu, J | 1 |
| Ajayi, N | 1 |
| Wu, SH | 1 |
| Barrett-Connor, E | 1 |
| Duggan, AJ | 1 |
| Watson, HJ | 1 |
| Binz, G | 1 |
| Ogada, T | 1 |
| Barret-Connor, E | 1 |
| Ugoretz, RJ | 1 |
| Braude, AI | 1 |
| Mastrandrea, G | 1 |
| Ilardi, I | 1 |
| Mazzacurati, G | 1 |
| Seah, SK | 1 |
| Flegel, KM | 1 |
| Hutchinson, MP | 1 |
| Neitz, WO | 1 |
| McCully, M | 1 |
| Klein, P | 1 |
| Jenny, M | 1 |
| Raether, W | 1 |
| Seidenath, H | 1 |
| Perera, DR | 1 |
| Donovan, DL | 1 |
| Stroud, GM | 1 |
15 reviews available for suramin and Trypanosomiasis, African
| Article | Year |
|---|---|
100 years since the publication of the suramin formula.
Topics: Animals; Humans; Suramin; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosomiasis | 2023 |
100 Years of Suramin.
Topics: Animals; Humans; Suramin; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, Afri | 2020 |
Clinical and Neuropathogenetic Aspects of Human African Trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Blood-Brain Barrier; Brain; Delayed Diagnosis; Humans; Incidence; Neg | 2019 |
Neglected Tropical Protozoan Diseases: Drug Repositioning as a Rational Option.
Topics: Antiprotozoal Agents; Chagas Disease; Drug Repositioning; Humans; Leishmaniasis; Neglected Diseases; | 2016 |
[Agents for the treatment of African sleeping sickness. Those developed in the last century].
Topics: Animals; Eflornithine; History, 20th Century; Humans; Melarsoprol; Nifurtimox; Pentamidine; Suramin; | 2009 |
Dyes, trypanosomiasis and DNA: a historical and critical review.
Topics: Acridines; Africa; Animals; Azo Compounds; Cattle; Chagas Disease; DNA; History, 19th Century; Histo | 2010 |
Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis.
Topics: Animals; Drug Resistance; HIV; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypa | 2003 |
Current chemotherapy of human African trypanosomiasis.
Topics: Animals; Eflornithine; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma; | 2003 |
THE CHEMOTHERAPY OF TRYPANOSOMIASIS.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antimony; Antiprotozoal Agents; Arsenic | 1963 |
Pharmacology of existing drugs for animal trypanosomiasis.
Topics: Animals; Arsenicals; Diminazene; Ethidium; Phenanthridines; Quinolinium Compounds; Suramin; Trypanoc | 1993 |
The treatment of human African trypanosomiasis.
Topics: Animals; Diminazene; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Suramin; Trypanocid | 1994 |
Transporters in African trypanosomes: role in drug action and resistance.
Topics: Africa South of the Sahara; Animals; Arsenicals; Biological Transport; Eflornithine; Humans; Nitroim | 2001 |
Chemotherapy of African trypanosomiasis.
Topics: Adult; Amidines; Animals; Cattle; Drug Resistance; Drug Therapy, Combination; Humans; Melarsoprol; P | 1976 |
Existing chemotherapy and its limitations.
Topics: Chagas Disease; Gentian Violet; Humans; Melarsoprol; Nifurtimox; Nitroimidazoles; Pentamidine; Suram | 1985 |
[Therapy of human African trypanosomiasis].
Topics: Amidines; Antimony; Arsenicals; Humans; Suramin; Trypanosomiasis, African | 1967 |
2 trials available for suramin and Trypanosomiasis, African
| Article | Year |
|---|---|
Safety and efficacy of the 10-day melarsoprol schedule for the treatment of second stage Rhodesiense sleeping sickness.
Topics: Adolescent; Adult; Aged; Brain Diseases; Child; Drug Administration Schedule; Endemic Diseases; Fema | 2012 |
Attempt to correlate urine arsenic excretion with clinical course during melarsoprol therapy of patients with Rhodesian trypanosomiasis.
Topics: Adolescent; Adult; Aged; Animals; Arsenic; Child; Child, Preschool; Creatinine; Drug Therapy, Combin | 1997 |
147 other studies available for suramin and Trypanosomiasis, African
| Article | Year |
|---|---|
Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents.
Topics: Animals; Cell Line; Kinetoplastida; Leishmania donovani; Microtubules; Models, Chemical; Models, Mol | 2007 |
Diamine and aminoalcohol derivatives active against Trypanosoma brucei.
Topics: Alcohols; Animals; Cell Death; Chemistry, Pharmaceutical; Chlorocebus aethiops; Diamines; Drug Desig | 2012 |
Inhibition of rhodesain as a novel therapeutic modality for human African trypanosomiasis.
Topics: Cathepsin L; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Protozoan Proteins; St | 2013 |
Novel pyrrolobenzoxaboroles: design, synthesis, and biological evaluation against Trypanosoma brucei.
Topics: Animals; Boron Compounds; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Design; F | 2014 |
Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Azabicyclo Compounds; Disease Models, Animal; D | 2015 |
Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity.
Topics: Animals; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Leukemia; Macrophages; Meth | 2015 |
Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model.
Topics: Animals; Diminazene; Disease Models, Animal; Drug Resistance; Kenya; Male; Melarsoprol; Mice; Pentam | 2020 |
Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Topics: Antigenic Variation; Binding Sites; Crystallography, X-Ray; Drug Resistance; Endocytosis; Immune Eva | 2021 |
Physiological and proteomic profiles of Trypanosoma brucei rhodesiense parasite isolated from suramin responsive and non-responsive HAT patients in Busoga, Uganda.
Topics: Animals; Humans; Male; Mice; Parasites; Proteomics; Suramin; Trypanosoma brucei brucei; Trypanosoma | 2021 |
Human African Trypanosomiasis in a Spanish traveler returning from Tanzania.
Topics: Diagnosis, Differential; Female; Humans; Middle Aged; Pentamidine; Spain; Suramin; Tanzania; Travel; | 2017 |
Beyond immune escape: a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei.
Topics: Animals; Antigenic Variation; Drug Resistance; Genome; Membrane Glycoproteins; Suramin; Trypanosoma | 2018 |
A case of delayed diagnosis of East-African trypanosomiasis in a Dutch traveller.
Topics: Animals; Delayed Diagnosis; Diagnosis, Differential; Female; Humans; Kenya; Malaria; Middle Aged; Ne | 2018 |
Trypanosoma brucei rhodesiense infection in a Chinese traveler returning from the Serengeti National Park in Tanzania.
Topics: Adult; China; Communicable Diseases, Imported; Female; Humans; Parks, Recreational; Pentamidine; Pol | 2018 |
Trypanocidal activity of tetradentated pyridine-based manganese complexes is not linked to inactivation of superoxide dismutase.
Topics: Antioxidants; Drug Interactions; Eflornithine; HL-60 Cells; Humans; Manganese Compounds; Microbial S | 2018 |
A veterinarian with fever, rash and chancre after holidays in Uganda.
Topics: Belgium; Female; Fever; Humans; Insect Bites and Stings; Middle Aged; Suramin; Travel; Trypanocidal | 2018 |
Insights into antitrypanosomal drug mode-of-action from cytology-based profiling.
Topics: Cell Biology; Humans; Lysosomes; Melarsoprol; Mitochondria; Mitochondrial Proteins; Mitosis; Nifurti | 2018 |
Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy.
Topics: Animals; Endocytosis; Endosomes; Humans; Membrane Glycoproteins; Protozoan Proteins; Suramin; Transp | 2013 |
Curative drug treatment of trypanosomosis leads to the restoration of B-cell lymphopoiesis and splenic B-cell compartments.
Topics: Animals; B-Lymphocyte Subsets; Bone Marrow; Diminazene; Female; Lymphopoiesis; Mice; Mice, Inbred C5 | 2015 |
African sleeping sickness.
Topics: Animals; Eflornithine; Humans; Insect Vectors; Nifurtimox; Pentamidine; Suramin; Trypanocidal Agents | 2016 |
Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein.
Topics: Adenine; Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Bl | 2009 |
In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin.
Topics: Alamethicin; Animals; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Cell Line; Cell Surviv | 2009 |
Human African trypanosomiasis.
Topics: Africa; Animals; Biomedical Research; Communicable Disease Control; Eflornithine; Endemic Diseases; | 2010 |
East African trypanosomiasis in a pregnant traveler.
Topics: Adult; Communicable Diseases, Emerging; Female; Humans; Infant, Newborn; London; Pentamidine; Pregna | 2009 |
Killer coma: the evolving story of sleeping sickness treatment.
Topics: Animals; Biomedical Research; Drug Discovery; Drug Resistance; Drug Therapy, Combination; Eflornithi | 2010 |
[The sleeping disease drug Germanine as an instrument for propaganda: reception in literature and film during National Socialism].
Topics: Germany; History, 20th Century; Humans; Literature, Modern; Medicine in Literature; Motion Pictures; | 2010 |
High-throughput decoding of antitrypanosomal drug efficacy and resistance.
Topics: Aquaglyceroporins; Drug Resistance; Eflornithine; Endocytosis; Glycosylation; High-Throughput Screen | 2012 |
Multiorgan dysfunction caused by travel-associated African trypanosomiasis.
Topics: Female; Humans; Middle Aged; Multiple Organ Failure; Suramin; Travel; Treatment Outcome; Trypanocida | 2012 |
Trypanosoma brucei rhodesiense infection in a German traveller returning from the Masai Mara area, Kenya, January 2012.
Topics: Animals; Chancre; Diagnosis, Differential; Fever; Fluorescent Antibody Technique; Germany; Headache; | 2012 |
Human African trypanosomiasis in a Belgian traveller returning from the Masai Mara area, Kenya, February 2012.
Topics: Belgium; Chancre; Fever; Headache; Humans; Kenya; Male; Polymerase Chain Reaction; Suramin; Travel; | 2012 |
A returning traveller with fever, facial swelling, and skin lesions.
Topics: Adrenal Cortex Hormones; Animals; Diagnosis, Differential; Disease Progression; Face; Fever; Humans; | 2012 |
Lesson of the month: a psychiatric diagnosis overturned by a blood film.
Topics: Antibodies, Protozoan; Cerebrospinal Fluid; Diagnosis, Differential; Female; Humans; Melarsoprol; Me | 2012 |
Investigating mammalian tyrosine phosphatase inhibitors as potential 'piggyback' leads to target Trypanosoma brucei transmission.
Topics: Animals; Humans; Mice; Models, Molecular; Protein Conformation; Protein Tyrosine Phosphatases; Proto | 2013 |
Human African trypanosomiasis: potential therapeutic benefits of an alternative suramin and melarsoprol regimen.
Topics: Animals; Anti-Infective Agents, Local; Drug Synergism; Drug Therapy, Combination; Female; Humans; Me | 2002 |
[The return of sleeping sickness in an epidemic form: international action for drugs].
Topics: Africa, Central; Animals; Disease Outbreaks; Eflornithine; Humans; International Cooperation; Melars | 2002 |
[Preliminary note on combined lomidine and moranyl in the prevention of sleeping sickness].
Topics: Amidines; Animals; Biomedical Research; Humans; Pentamidine; Suramin; Trypanosomiasis; Trypanosomias | 1955 |
Suramin complexes. I. Prophylactic activity against Trypanosoma congolense in small animals.
Topics: Animals; Suramin; Trypanosoma congolense; Trypanosomiasis; Trypanosomiasis, African | 1957 |
Suramin complexes. V. Ethidium complex: attempts to overcome the injection-site reaction in cattle.
Topics: Animals; Black People; Cattle; Cattle Diseases; Ethidium; Humans; Quinolines; Suramin; Trypanosomias | 1958 |
[Chemotherapy and chemoprophylaxis of sleeping sickness caused by Trypanosoma gambiense].
Topics: Animals; Arsenicals; Chemoprevention; Humans; Pentamidine; Suramin; Trypanosoma brucei gambiense; Tr | 1959 |
Suramin complexes. VII. Further attempts to overcome the ethidium complex injection-site reaction.
Topics: Animals; Cattle; Cattle Diseases; Ethidium; Quinolines; Sheep; Sheep Diseases; Suramin; Trypanosomia | 1961 |
The trypanocidal activity and local tolerance of sparingly soluble salts of metamidium.
Topics: Antiparasitic Agents; Salts; Suramin; Trypanosomiasis; Trypanosomiasis, African | 1961 |
[Treatment of human African trypanosomiasis].
Topics: Amidines; Animals; Antiparasitic Agents; Humans; Suramin; Trypanosomiasis; Trypanosomiasis, African | 1963 |
Chemotherapy and chemoprophylaxis of African trypanosomiasis.
Topics: Acridines; Amidines; Animals; Anti-Bacterial Agents; Arsenicals; Chemoprevention; Drug Resistance; D | 1962 |
THE HUMAN TRYPANOSOMATIDAE. I.
Topics: Amidines; Animals; Dimercaprol; Humans; Pathology; Suramin; Trypanosomatina; Trypanosomiasis; Trypan | 1963 |
PROPHYLACTIC ACTIVITY OF SURAMIN COMPLEXES IN 'SURRA' (TRYPANOSOMA EVANSI).
Topics: Animals; Antiprotozoal Agents; India; Mice; Pharmacology; Quinolines; Rats; Research; Suramin; Trypa | 1963 |
[STUDY OF A SLIGHTLY VIRULENT STRAIN OF T. GAMBIENSE ISOLATED IN A EUROPEAN IN THE FORMER BELGIAN CONGO].
Topics: Animals; Antiprotozoal Agents; Carrier State; Cerebrospinal Fluid; Congo; Democratic Republic of the | 1963 |
CHEMOTHERAPY OF TROPICAL DISEASES.
Topics: Amebiasis; Amebicides; Anti-Bacterial Agents; Antimalarials; Antimony; Arsenicals; Chagas Disease; C | 1964 |
[SLEEPING SICKNESS. AFRICAN TRYPANOSOMIASIS].
Topics: Africa; Africa, Central; Amidines; Animals; Diagnosis; Drug Therapy; Humans; Suramin; Trypanosomiasi | 1964 |
Megazol combined with suramin improves a new diagnosis index of the early meningo-encephalitic phase of experimental African trypanosomiasis.
Topics: Anemia; Animals; Body Weight; Drug Therapy, Combination; Eating; Hematocrit; Male; Meningoencephalit | 2004 |
Sleeping sickness in brothers in london.
Topics: Adolescent; Animals; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-U | 2004 |
Orchitis as an unusual manifestation of human African trypanosomiasis.
Topics: Adult; Humans; Male; Orchitis; Suramin; Trypanocidal Agents; Trypanosomiasis, African | 2006 |
Drug-resistance of Trypanosoma b. rhodesiense isolates from Tanzania.
Topics: Animals; Diminazene; Drug Resistance; Humans; Mass Screening; Melarsoprol; Phenanthridines; Recurren | 2006 |
The effect of TAO expression on PCD-like phenomenon development and drug resistance in Trypanosoma brucei.
Topics: Animals; Apoptosis; Dose-Response Relationship, Drug; Drug Resistance; Gene Expression Regulation, E | 2006 |
Transverse myelitis due to trypanosomiasis in a middle aged Tanzanian man.
Topics: Animals; Developing Countries; Drug Therapy, Combination; Follow-Up Studies; Humans; Male; Melarsopr | 2006 |
A woman with fever and rash after African safari.
Topics: Africa; Exanthema; Female; Fever; Humans; Melarsoprol; Middle Aged; Pentamidine; Suramin; Travel; Tr | 2006 |
African trypanosomiasis in a British soldier.
Topics: Adult; Antinematodal Agents; Chancre; Erythema; Fever; Humans; Injections; Male; Military Personnel; | 2006 |
Treatment failure related to intrathecal immunoglobulin M (IgM) synthesis, cerebrospinal fluid IgM, and interleukin-10 in patients with hemolymphatic-stage sleeping sickness.
Topics: Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Biomarkers; Central Nervous System Protozoa | 2007 |
African trypanosomiasis in a British soldier.
Topics: Adult; Animals; Humans; Malawi; Male; Military Medicine; Military Personnel; Parasitic Diseases; Sur | 2007 |
Suramin and minocycline treatment of experimental African trypanososmiasis at an early stage of parasite brain invasion.
Topics: Animals; Antiprotozoal Agents; Brain; Drug Therapy, Combination; Male; Mice; Mice, Inbred C57BL; Min | 2008 |
An improved method for the estimation of suramin in plasma and trypanosome samples.
Topics: Animals; Hydrolysis; Methods; Rats; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African | 1980 |
Uptake of the trypanocidal drug suramin by bloodstream forms of Trypanosoma brucei and its effect on respiration and growth rate in vivo.
Topics: Animals; Glycolysis; Male; Oxygen Consumption; Rats; Suramin; Trypanosoma brucei brucei; Trypanosomi | 1980 |
Drug sensitivity of pleomorphic Trypanosoma rhodesiense.
Topics: Animals; Arsenicals; Drug Resistance, Microbial; Ethidium; Mice; Pentamidine; Quinolinium Compounds; | 1983 |
Arsenic and old taxa: subspeciation and drug sensitivity in Trypanosoma brucei.
Topics: Animals; Arsenicals; Diminazene; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Isoen | 1984 |
New drug combination for experimental late-stage African trypanosomiasis: DL-alpha-difluoromethylornithine (DFMO) with suramin.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Eflornithine; Humans; Injections, Intrav | 1984 |
The use of 2-substituted 5-nitroimidazoles in the treatment of chronic murine Trypanosoma brucei infections with central nervous system involvement.
Topics: Animals; Antiprotozoal Agents; Brain; Chronic Disease; Drug Therapy, Combination; Female; Mice; Mice | 1984 |
The use of the 2 substituted 5-nitroimidazole, Fexinidazole (Hoe 239) in the treatment of chronic T. brucei infections in mice.
Topics: Animals; Antiprotozoal Agents; Chronic Disease; Diminazene; Drug Therapy, Combination; Female; Mice; | 1983 |
Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murine Trypanosoma brucei infections with central nervous system involvement.
Topics: Animals; Antiprotozoal Agents; Cattle; Central Nervous System Diseases; Drug Therapy, Combination; F | 1983 |
African trypanosomiasis in an American hunter in East Africa.
Topics: Adult; Diagnostic Errors; Humans; Male; Sudan; Suramin; Travel; Trypanosomiasis, African | 1983 |
Response of the rat's hepatic drug-metabolizing enzyme system to chemotherapy of Trypanosoma b. brucei infections with Berenil and Suramin.
Topics: Amidines; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Diminazene; Female; Glutamate Deh | 1984 |
African trypanosomiasis in the United States.
Topics: Africa; Aged; Humans; Insect Vectors; Male; Skin Diseases, Parasitic; Suramin; Travel; Trypanosomias | 1983 |
An accidental laboratory infection with African trypanosomes of a defined stock. I. The clinical course of the infection.
Topics: Adult; Animals; Antigens; Humans; Immunoglobulin M; Laboratory Infection; Male; Rats; Scotland; Sura | 1980 |
Hepatic mixed-function oxidase activity in mice infected with Trypanosoma brucei gambiense or treated with trypanocides.
Topics: Animals; Arsenicals; Cytochrome P-450 Enzyme System; Liver; Male; Melarsoprol; Mice; Mixed Function | 1981 |
[African sleeping sickness in The Netherlands].
Topics: Animals; Antibodies, Protozoan; Antiprotozoal Agents; Blood; Cerebrospinal Fluid; Diagnosis, Differe | 1995 |
[Current therapy of trypanosomiasis].
Topics: Adenosylmethionine Decarboxylase; Animals; Arsenicals; Deoxyadenosines; Drug Resistance; Eflornithin | 1994 |
In vivo evaluation of reuterin and its combinations with suramin, melarsoprol, DL-alpha-difluoromethylornithine and bleomycin in mice infected with Trypanosoma brucei brucei.
Topics: Aldehydes; Animals; Anti-Bacterial Agents; Bleomycin; Drug Therapy, Combination; Eflornithine; Femal | 1993 |
Establishment of a partly DFMO-sensitive primate model of Trypanosoma rhodesiense sleeping sickness.
Topics: Animals; Chlorocebus aethiops; Disease Models, Animal; Drug Therapy, Combination; Eflornithine; Sura | 1995 |
Delayed recovery of adrenocortical and testicular function after chemotherapy of human trypanosomiasis.
Topics: Adolescent; Adrenal Cortex; Adult; Aged; Anemia; Animals; Hematocrit; Humans; Hydrocortisone; Hypogo | 1994 |
[Fever after travel to the tropics in Africa: the etiology is not always malaria].
Topics: Adult; Democratic Republic of the Congo; Diagnosis, Differential; Fever of Unknown Origin; Humans; M | 1994 |
[Polyneuritis and myositis in Trypanosoma gambiense infection].
Topics: Animals; Diagnosis, Differential; Drug Therapy, Combination; Electrocardiography; Electromyography; | 1994 |
Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides.
Topics: Animals; Arsenicals; Diminazene; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Eflo | 1994 |
Innate lack of susceptibility of Ugandan Trypanosoma brucei rhodesiense to DL-alpha-difluoromethylornithine (DFMO).
Topics: Animals; Drug Resistance; Eflornithine; Female; Humans; Hypoxanthine; Hypoxanthines; Melarsoprol; Mi | 1995 |
Trypanosoma brucei brucei: a long-term model of human African trypanosomiasis in mice, meningo-encephalitis, astrocytosis, and neurological disorders.
Topics: Animals; Astrocytes; Brain; Choroid Plexus; Disease Models, Animal; Female; Meninges; Meningoencepha | 1997 |
Increased excretion of aromatic amino acid catabolites in animals infected with Trypanosoma brucei evansi.
Topics: Amino Acids; Animals; Dog Diseases; Dogs; Equidae; Female; Gas Chromatography-Mass Spectrometry; Hyd | 1998 |
Megazol combined with suramin: a chemotherapy regimen which reversed the CNS pathology in a model of human African trypanosomiasis in mice.
Topics: Animals; Body Weight; Central Nervous System Diseases; Disease Models, Animal; Drug Evaluation, Prec | 1998 |
[In vivo resistance to strains of Trypanosoma rhodesiense, Mozambique, 1985].
Topics: Animals; Drug Resistance; Humans; Melarsoprol; Mice; Suramin; Trypanocidal Agents; Trypanosoma bruce | 1991 |
Drug resistance in Sudanese Trypanosoma evansi.
Topics: Animals; Camelus; Chromatography, Ion Exchange; Drug Resistance; Female; Hypoxanthine; Inhibitory Co | 1999 |
Rhodesian trypanosomiasis in a splenectomized patient.
Topics: Adult; Africa; Animals; Central Nervous System Diseases; Humans; Male; Melarsoprol; Splenectomy; Sur | 1999 |
Anti-sleeping sickness drugs and cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Eflornithine; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocida | 2000 |
Fulminant disease simulating bacterial sepsis with disseminated intravascular coagulation after a trip to East Africa.
Topics: Africa, Eastern; Animals; Bacterial Infections; Diagnosis, Differential; Disseminated Intravascular | 2000 |
Treatment of human African trypanosomiasis.
Topics: Acetanilides; Africa; Humans; Melarsoprol; Nitroimidazoles; Pentamidine; Suramin; Thiadiazoles; Tryp | 2000 |
Availability and affordability of treatment for Human African Trypanosomiasis.
Topics: Eflornithine; Health Services Accessibility; Humans; Melarsoprol; Pentamidine; Research; Suramin; Tr | 2001 |
African trypanosomiasis in travelers returning to the United Kingdom.
Topics: Adult; Humans; Kenya; Male; Middle Aged; Suramin; Tanzania; Travel; Trypanocidal Agents; Trypanosomi | 2002 |
[African trypanosomiasis--a rare imported disease].
Topics: Adult; Female; Humans; Risk; Suramin; Travel; Tropical Medicine; Trypanocidal Agents; Trypanosomiasi | 2002 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 20-2002. A 37-year-old man with fever, hepatosplenomegaly, and a cutaneous foot lesion after a trip to Africa.
Topics: Adult; Africa; Animals; Anthrax; Blood; Cerebrospinal Fluid; Diagnosis, Differential; Erythema; Feve | 2002 |
Evidence for a non-LDL-mediated entry route for the trypanocidal drug suramin in Trypanosoma brucei.
Topics: Animals; Endocytosis; Lipoproteins, LDL; Parasitic Sensitivity Tests; rab4 GTP-Binding Proteins; rab | 2002 |
Chemotherapy of African trypanosomiasis.
Topics: Arsenicals; Diminazene; Humans; Suramin; Triazines; Trypanocidal Agents; Trypanosomiasis, African | 1976 |
Chemotherapy of sleeping sickness.
Topics: Arsenicals; Humans; Melarsoprol; Pentamidine; Suramin; Trypanosomiasis, African | 1979 |
[Imported East-African trypanosomiasis (sleeping sickness)].
Topics: Botswana; Diagnosis, Differential; Germany, West; Humans; Malaria; Male; Middle Aged; Suramin; Trypa | 1977 |
Imported African trypanosomiasis in the United States.
Topics: Adult; Aged; Diagnosis, Differential; Female; Humans; Male; Melarsoprol; Middle Aged; Suramin; Trypa | 1975 |
An evaluation of prednisolone as a routine adjunct to the treatment of T. rhodesiense.
Topics: Adult; Arsenicals; Child; Drug Administration Schedule; Drug Evaluation, Preclinical; Humans; Melars | 1975 |
The treatment of T. rhodesiense sleeping sickness, with special reference to its physio-pathological and epidemiological basis.
Topics: Arsenicals; Chloroquine; Humans; Melarsoprol; Proguanil; Suramin; Trypanosomiasis, African; Zambia | 1975 |
A case of congenital trypanosomiasis in Lagos.
Topics: Acid-Base Equilibrium; Autopsy; Brain; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; M | 1975 |
Electrocardiographic changes in African trypanosomiasis caused by Trypanosoma brucei rhodesiense.
Topics: Adolescent; Adult; Aged; Electrocardiography; Female; Heart Diseases; Humans; Male; Melarsoprol; Mid | 1975 |
Algorithms in the diagnosis and management of exotic diseases. XI. African trypanosomiases.
Topics: Acute Disease; Blood; Blood Sedimentation; Cerebrospinal Fluid; Chronic Disease; Humans; Lymph Nodes | 1976 |
Evaluation of DL-alpha-difluoromethylornithine against susceptible and drug-resistant Trypanosoma brucei brucei.
Topics: Animals; Arsenicals; Culture Media; Diminazene; Drug Antagonism; Drug Synergism; Drug Therapy, Combi | 1991 |
Elevation of the concentration of acute phase proteins in dogs infected with Trypanosoma brucei.
Topics: Animals; C-Reactive Protein; Dog Diseases; Dogs; Haptoglobins; Suramin; Trypanosoma brucei brucei; T | 1991 |
Chemotherapy of CNS-trypanosomiasis: combination chemotherapy with a 5-nitroimidazole (MK 436), an arsenical (Cymelarsan) and suramin.
Topics: Animals; Arsenicals; Brain Diseases; Disease Models, Animal; Drug Therapy, Combination; Female; Mice | 1991 |
Chemotherapy of CNS-trypanosomiasis: the combined use of the arsenicals and nitro-compounds.
Topics: Animals; Antiprotozoal Agents; Arsenicals; Brain Diseases; Drug Synergism; Drug Therapy, Combination | 1991 |
Trypanosoma brucei evansi: dyskinetoplasia and loss of infectivity after long-term in vitro cultivation.
Topics: Animals; Diminazene; DNA, Circular; DNA, Kinetoplast; Female; Male; Mice; Microscopy, Electron; Phen | 1990 |
Studies on the efficacy of DL-alpha-difluoromethylornithine (DFMO) associated with bleomycin and suramin for treatment of mice infected with metacyclic forms of Trypanosoma brucei brucei.
Topics: Animals; Bleomycin; Drug Therapy, Combination; Eflornithine; Female; Mice; Suramin; Trypanosoma bruc | 1987 |
Screening compounds for sleeping sickness therapy without relapse.
Topics: Animals; Bleomycin; Drug Evaluation, Preclinical; Eflornithine; Melarsoprol; Metronidazole; Mice; Su | 1988 |
Treatment of arsenical refractory Rhodesian sleeping sickness in Kenya.
Topics: Adult; Animals; Arsenicals; Drug Therapy, Combination; Eflornithine; Female; Humans; Kenya; Male; Me | 1989 |
Tryparsamide.
Topics: Drug Therapy, Combination; Humans; Melarsoprol; Nigeria; Pentamidine; Suramin; Trypanocidal Agents; | 1989 |
In vitro drug sensitivity of Trypanosoma gambiense isolates.
Topics: Animals; Arsenicals; Cote d'Ivoire; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; | 1989 |
Experimental infection of goats with Trypanosoma brucei ssp. and effects of treatment with suramin and Mel-B.
Topics: Animals; Arsenicals; Brain; Central Nervous System; Central Nervous System Diseases; Goat Diseases; | 1989 |
Treatment of Rhodesian sleeping sickness in Kenya.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Arsenicals; Child; Drug Resistance; Female; Fol | 1989 |
[Sleeping sickness in German travelers to the tropics].
Topics: Adult; Africa, Central; Female; Germany; Humans; Male; Middle Aged; Risk Factors; Suramin; Travel; T | 1989 |
Suramin/metronidazole combination for African sleeping sickness.
Topics: Drug Therapy, Combination; Humans; Metronidazole; Suramin; Trypanosomiasis, African | 1985 |
The effect of trypanocidal drugs on the transmission of Trypanosoma brucei brucei by Glossina morsitans centralis.
Topics: Animals; Diminazene; Pentamidine; Phenanthridines; Suramin; Trypanocidal Agents; Trypanosoma brucei | 1987 |
The relapse of Trypanosoma brucei brucei infections after chemotherapy in rabbits.
Topics: Amidines; Animals; Diminazene; Female; Male; Mice; Rabbits; Recurrence; Suramin; Trypanosoma brucei | 1988 |
Severe African trypanosomiasis with spurious hypoglycemia.
Topics: Animals; Blood Glucose; Diagnostic Errors; Female; Humans; Hypoglycemia; Middle Aged; Suramin; Trypa | 1989 |
Effects of the ornithine decarboxylase inhibitors DL-alpha-difluoromethylornithine and alpha-monofluoromethyldehydroornithine methyl ester alone and in combination with suramin against Trypanosoma brucei brucei central nervous system models.
Topics: Animals; Central Nervous System; Dose-Response Relationship, Drug; Drug Therapy, Combination; Eflorn | 1987 |
Chemotherapy of trypanosomiasis: the use of guanylhydrazone compounds in the treatment of experimental murine trypanosomiasis.
Topics: Animals; Drug Therapy, Combination; Eflornithine; Female; Mice; Mitoguazone; Suramin; Trypanocidal A | 1987 |
[Action of drugs tested in an acellular medium and in mice infected with Trypanosoma brucei brucei].
Topics: Acetanilides; Animals; Culture Media; Cyclosporins; Eflornithine; In Vitro Techniques; Melarsoprol; | 1988 |
Chemotherapy of chronic trypanosomiasis: the failure of ketoconazole to cure murine infections of Trypanosoma brucei with central nervous system involvement.
Topics: Animals; Central Nervous System Diseases; Chronic Disease; Drug Therapy, Combination; Ketoconazole; | 1988 |
Suramin and metronidazole in the treatment of Trypanosoma brucei rhodesiense.
Topics: Adult; Animals; Drug Therapy, Combination; Humans; Male; Metronidazole; Mozambique; Suramin; Trypano | 1988 |
[Conventional and analytic morphometry using the IBAS-1 computer in experimental Trypanosoma b. brucei infection].
Topics: Animals; Computers; Male; Mice; Mice, Inbred Strains; Microscopy; Suramin; Trypanosoma brucei brucei | 1987 |
Trypanocidal activity of a 5-substituted 2-nitroimidazole compound (Ro 15-0216) in mice.
Topics: Acetanilides; Animals; Drug Therapy, Combination; Female; Male; Mice; Nitroimidazoles; Suramin; Tryp | 1987 |
Chemotherapy of late-stage trypanosomiasis: the effect of the nitrothiazole compounds.
Topics: Animals; Drug Therapy, Combination; Mice; Niridazole; Suramin; Trypanocidal Agents; Trypanosoma bruc | 1987 |
Trypanosoma brucei and T. vivax: salicylhydroxamic acid and glycerol treatment of acute and chronically infected rats.
Topics: Animals; Brain; Drug Administration Schedule; Drug Therapy, Combination; Female; Glycerol; Melarsopr | 1986 |
The clinical manifestations of Rhodesian trypanosomiasis: an account of cases contracted in the Okavango swamps of Botswana.
Topics: Adult; Botswana; Humans; Male; Middle Aged; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, Afr | 1986 |
Hyperendemic West African trypanosomiasis in a rural hospital setting.
Topics: Brain Diseases; Dexamethasone; Drug Administration Schedule; Drug Therapy, Combination; Hospitals, R | 1985 |
African human trypanosomiasis in southern Sudan. Report of 77 cases.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Male; Melarsoprol; Middle Aged; Sudan; S | 1985 |
Induction of human serum-sensitive Trypanosoma brucei stabilates into human serum-resistant "T. rhodesiense".
Topics: Animals; Blood Physiological Phenomena; Brain; Female; Humans; Mice; Suramin; Trypanosoma brucei bru | 1985 |
Protection of the sleeping sickness trypanosome from chemotherapy by different parts of the brain.
Topics: Animals; Blood-Brain Barrier; Cerebral Cortex; Cerebral Ventricles; Choroid Plexus; Female; Glycerol | 1985 |
Chemoprophylaxis of amebiasis and African trypanosomiasis.
Topics: Acetates; Amebiasis; Amides; Amidines; Antiprotozoal Agents; Arsenicals; Clioquinol; Humans; Intesti | 1972 |
The treatment of African trypanosomiasis.
Topics: Africa, Eastern; Africa, Western; Amidines; Arsenicals; Humans; Injections, Intramuscular; Injection | 1973 |
The epidemiology of human sleeping sickness in the Lambwe Valley, South Nyanza, Kenya.
Topics: Adolescent; Adult; Age Factors; Arsenicals; Child; Disease Reservoirs; Female; Humans; Kenya; Male; | 1972 |
Observations on levels of immunoglobulin M in confirmed cases of Trypanosoma rhodesiense infection in the Lambwe Valley.
Topics: Arsenicals; Chronic Disease; Humans; Immunoglobulin M; Kenya; Suramin; Time Factors; Triazines; Tryp | 1972 |
The management of human trypanosomiasis.
Topics: Amidines; Antiprotozoal Agents; Arsenicals; Encephalitis; Furosemide; Glycine; Humans; Suramin; Tria | 1972 |
Disseminated intravascular coagulation in trypanosomiasis.
Topics: Adult; Anemia, Hemolytic; Botswana; California; Complement System Proteins; Coombs Test; Disseminate | 1973 |
African trypanosomiasis in Canada.
Topics: Adult; Canada; Female; Humans; Suramin; Trypanosomiasis, African | 1972 |
Human trypanosomiasis in South-West Ethiopia (March 1967-March 1970).
Topics: Adolescent; Adult; Child; Child, Preschool; Disease Outbreaks; Disease Reservoirs; Environment; Ethi | 1971 |
Clinicopathological study on experimental Trypanosoma brucei infections in horses. 1. Development of clinically recognizable nervous symptoms in nagana-infected horses treated with subcurative doses of Antrypol and Berenil.
Topics: Acetates; Amidines; Animals; Azo Compounds; Brain; Chronic Disease; Glycine; Horse Diseases; Horses; | 1971 |
[On the ideological history of the early period of chemotherapy].
Topics: Animals; Arsphenamine; Birds; Drug Therapy; History, 20th Century; Humans; Malaria; Malaria, Avian; | 1966 |
[African trypanosomiasis. A propos of a case of sleeping sickness treated in Switzerland].
Topics: Arsenic; Humans; Male; Middle Aged; Suramin; Trypanosomiasis, African | 1970 |
[Curative and preventive effect of Berenil afe oraland subcutaneous administration in experimental trypanosomiasis (Trypanoso rhodesiense, T.gambiense)].
Topics: Acetates; Amidines; Animals; Antiprotozoal Agents; Azo Compounds; Cresols; Glycine; Mice; Phenanthri | 1971 |
Imported African sleeping sickness.
Topics: Florida; Humans; Male; Middle Aged; Suramin; Trypanosomiasis, African | 1969 |