suramin has been researched along with Thrombopenia in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors report a case of suramin-induced immune-mediated thrombocytopenia occurring in a patient on a Phase II protocol for treatment of metastatic renal cell carcinoma." | 7.68 | Immune-mediated thrombocytopenia secondary to suramin. ( Reich, L; Scher, HI; Schwartz, M; Seidman, AD, 1993) |
| "The authors report a case of suramin-induced immune-mediated thrombocytopenia occurring in a patient on a Phase II protocol for treatment of metastatic renal cell carcinoma." | 3.68 | Immune-mediated thrombocytopenia secondary to suramin. ( Reich, L; Scher, HI; Schwartz, M; Seidman, AD, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seidman, AD | 1 |
| Schwartz, M | 1 |
| Reich, L | 1 |
| Scher, HI | 1 |
| Tisdale, JF | 1 |
| Figg, WD | 1 |
| Reed, E | 1 |
| McCall, NA | 1 |
| Alkins, BR | 1 |
| Horne, MK | 1 |
1 trial available for suramin and Thrombopenia
| Article | Year |
|---|---|
Severe thrombocytopenia in patients treated with suramin: evidence for an immune mechanism in one.
Topics: Antineoplastic Agents; Humans; Immunoglobulin G; Male; Middle Aged; Neoplasm Metastasis; Platelet Ag | 1996 |
1 other study available for suramin and Thrombopenia
| Article | Year |
|---|---|
Immune-mediated thrombocytopenia secondary to suramin.
Topics: Humans; Male; Middle Aged; Suramin; Thrombocytopenia | 1993 |