Page last updated: 2024-11-04

suramin and Thrombopenia

suramin has been researched along with Thrombopenia in 2 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Research Excerpts

ExcerptRelevanceReference
"The authors report a case of suramin-induced immune-mediated thrombocytopenia occurring in a patient on a Phase II protocol for treatment of metastatic renal cell carcinoma."7.68Immune-mediated thrombocytopenia secondary to suramin. ( Reich, L; Scher, HI; Schwartz, M; Seidman, AD, 1993)
"The authors report a case of suramin-induced immune-mediated thrombocytopenia occurring in a patient on a Phase II protocol for treatment of metastatic renal cell carcinoma."3.68Immune-mediated thrombocytopenia secondary to suramin. ( Reich, L; Scher, HI; Schwartz, M; Seidman, AD, 1993)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Seidman, AD1
Schwartz, M1
Reich, L1
Scher, HI1
Tisdale, JF1
Figg, WD1
Reed, E1
McCall, NA1
Alkins, BR1
Horne, MK1

Trials

1 trial available for suramin and Thrombopenia

ArticleYear
Severe thrombocytopenia in patients treated with suramin: evidence for an immune mechanism in one.
    American journal of hematology, 1996, Volume: 51, Issue:2

    Topics: Antineoplastic Agents; Humans; Immunoglobulin G; Male; Middle Aged; Neoplasm Metastasis; Platelet Ag

1996

Other Studies

1 other study available for suramin and Thrombopenia

ArticleYear
Immune-mediated thrombocytopenia secondary to suramin.
    Cancer, 1993, Feb-01, Volume: 71, Issue:3

    Topics: Humans; Male; Middle Aged; Suramin; Thrombocytopenia

1993