suramin has been researched along with Teratocarcinoma in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Teratocarcinoma: A malignant neoplasm consisting of elements of teratoma with those of embryonal carcinoma or choriocarcinoma, or both. It occurs most often in the testis. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Based on these data, the effects of suramin were studied on the growth of a monolayer culture of two human teratocarcinoma cell lines, NT2/D1 and N2102ep." | 5.07 | Suramin for germ cell tumors. In vitro growth inhibition and results of a phase II trial. ( Bajorin, DF; Bost, GJ; Dmitrovsky, E; Miller, WH; Motzer, RJ; Scher, HI; Tong, WP, 1993) |
| "Suramin treatment increased the 125I-FGF-2 binding capacity of undifferentiated F9 cells threefold but had little effect on the binding capacity of differentiated cells." | 1.29 | Autocrine downregulation of fibroblast growth factor receptors in F9 teratocarcinoma cells. ( Moscatelli, D, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moscatelli, D | 1 |
| Motzer, RJ | 1 |
| Dmitrovsky, E | 1 |
| Miller, WH | 1 |
| Tong, WP | 1 |
| Bajorin, DF | 1 |
| Scher, HI | 1 |
| Bost, GJ | 1 |
1 trial available for suramin and Teratocarcinoma
| Article | Year |
|---|---|
Suramin for germ cell tumors. In vitro growth inhibition and results of a phase II trial.
Topics: Adult; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance; Female; Germinoma; Humans; Infu | 1993 |
1 other study available for suramin and Teratocarcinoma
| Article | Year |
|---|---|
Autocrine downregulation of fibroblast growth factor receptors in F9 teratocarcinoma cells.
Topics: Animals; Bucladesine; Cell Differentiation; Cross-Linking Reagents; Down-Regulation; Fibroblast Grow | 1994 |