suramin has been researched along with Spinal Cord Injuries in 5 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although astrogliosis and glial scar formation have been involved in both damage and repair processes after SCI, their role remains controversial." | 1.38 | Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue. ( Figueroa, JD; Miranda, JD; RodrÃguez-Zayas, AE; Rosas, OR; Santiago, JM; Torrado, AI, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, CL | 1 |
| Yang, XL | 1 |
| Wang, JJ | 1 |
| Du, GH | 1 |
| Yang, WM | 1 |
| Zhang, HP | 1 |
| Matsumura, S | 1 |
| Takagi, K | 1 |
| Okuda-Ashitaka, E | 1 |
| Lu, J | 1 |
| Naritsuka, H | 1 |
| Yamaguchi, M | 1 |
| Ito, S | 1 |
| Rummery, NM | 1 |
| Tripovic, D | 1 |
| McLachlan, EM | 2 |
| Brock, JA | 2 |
| RodrÃguez-Zayas, AE | 1 |
| Torrado, AI | 1 |
| Rosas, OR | 1 |
| Santiago, JM | 1 |
| Figueroa, JD | 1 |
| Miranda, JD | 1 |
| Yeoh, M | 1 |
5 other studies available for suramin and Spinal Cord Injuries
| Article | Year |
|---|---|
Effects of intracavernous injection of P2X3 and NK1 receptor antagonists on erectile dysfunction induced by spinal cord transection in rats.
Topics: Animals; Disease Models, Animal; Erectile Dysfunction; Ganglia, Spinal; Immunohistochemistry; Inject | 2015 |
Characterization of nestin expression in the spinal cord of GFP transgenic mice after peripheral nerve injury.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Proliferation; Green Fluorescent Proteins; Intermedia | 2010 |
Sympathetic vasoconstriction is potentiated in arteries caudal but not rostral to a spinal cord transection in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Clonidine; Data Interpre | 2010 |
Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue.
Topics: Animals; Antineoplastic Agents; Astrocytes; Behavior, Animal; Female; Glial Fibrillary Acidic Protei | 2012 |
Enhanced neurally evoked responses and inhibition of norepinephrine reuptake in rat mesenteric arteries after spinal transection.
Topics: Adenosine Triphosphate; Animals; Autonomic Dysreflexia; Electric Stimulation; Female; Mesenteric Art | 2006 |