suramin has been researched along with Sensitivity and Specificity in 11 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Relapses were significantly correlated with intrathecal IgM synthesis (odds ratio [OR], 46; 95% confidence interval [CI], 8 to 260), a CSF IgM concentration of >or=1." | 1.34 | Treatment failure related to intrathecal immunoglobulin M (IgM) synthesis, cerebrospinal fluid IgM, and interleukin-10 in patients with hemolymphatic-stage sleeping sickness. ( Bisser, S; Boelaert, M; Büscher, P; Hoogstoel, A; Lejon, V; Mumba, D; N'Siesi, FX; Reiber, H; Robays, J, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (54.55) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wigle, TJ | 1 |
| Singleton, SF | 1 |
| Inoue, N | 1 |
| Winter, J | 1 |
| Lal, RB | 1 |
| Offermann, MK | 1 |
| Koyano, S | 1 |
| Niemistö, A | 1 |
| Dunmire, V | 1 |
| Yli-Harja, O | 1 |
| Zhang, W | 1 |
| Shmulevich, I | 1 |
| Lejon, V | 1 |
| Robays, J | 1 |
| N'Siesi, FX | 1 |
| Mumba, D | 1 |
| Hoogstoel, A | 1 |
| Bisser, S | 1 |
| Reiber, H | 1 |
| Boelaert, M | 1 |
| Büscher, P | 1 |
| Monzón, CM | 1 |
| Jara, A | 1 |
| Nantulya, VM | 1 |
| Castro, E | 1 |
| Mateo, J | 1 |
| Tomé, AR | 1 |
| Barbosa, RM | 1 |
| Miras-Portugal, MT | 1 |
| Rosário, LM | 1 |
| Trezise, DJ | 1 |
| Kennedy, I | 1 |
| Humphrey, PP | 1 |
| Kraft, A | 1 |
| Reid, LM | 1 |
| Zvibel, I | 1 |
| Kassack, M | 1 |
| Nickel, P | 1 |
| Bültmann, R | 1 |
| Trendelenburg, M | 1 |
| Tuluc, F | 1 |
| Wittenburg, H | 1 |
| Starke, K | 1 |
| Small, EJ | 1 |
| McMillan, A | 1 |
| Meyer, M | 1 |
| Chen, L | 1 |
| Slichenmyer, WJ | 1 |
| Lenehan, PF | 1 |
| Eisenberger, M | 1 |
1 trial available for suramin and Sensitivity and Specificity
| Article | Year |
|---|---|
Serum prostate-specific antigen decline as a marker of clinical outcome in hormone-refractory prostate cancer patients: association with progression-free survival, pain end points, and survival.
Topics: Adenocarcinoma; Adult; Aged; Anti-Inflammatory Agents; Antineoplastic Agents; Biomarkers, Tumor; Dis | 2001 |
10 other studies available for suramin and Sensitivity and Specificity
| Article | Year |
|---|---|
Directed molecular screening for RecA ATPase inhibitors.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Binding Sites; Biological | 2007 |
Characterization of entry mechanisms of human herpesvirus 8 by using an Rta-dependent reporter cell line.
Topics: Cell Line; Genes, Reporter; Heparitin Sulfate; Herpesvirus 8, Human; Humans; Hydrogen-Ion Concentrat | 2003 |
Robust quantification of in vitro angiogenesis through image analysis.
Topics: Algorithms; Animals; Artificial Intelligence; Cells, Cultured; Coculture Techniques; Endothelial Cel | 2005 |
Treatment failure related to intrathecal immunoglobulin M (IgM) synthesis, cerebrospinal fluid IgM, and interleukin-10 in patients with hemolymphatic-stage sleeping sickness.
Topics: Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Biomarkers; Central Nervous System Protozoa | 2007 |
Sensitivity of antigen ELISA test for detecting Trypanosoma evansi antigen in horses in the subtropical area of Argentina.
Topics: Animals; Antigens, Protozoan; Argentina; Diminazene; Disease Outbreaks; Enzyme-Linked Immunosorbent | 1995 |
Cell-specific purinergic receptors coupled to Ca2+ entry and Ca2+ release from internal stores in adrenal chromaffin cells. Differential sensitivity to UTP and suramin.
Topics: Adenosine Triphosphate; Adrenal Medulla; Animals; Calcium; Cattle; Cells, Cultured; Dimethylphenylpi | 1995 |
Characterization of purinoceptors mediating depolarization of rat isolated vagus nerve.
Topics: Adenosine Triphosphate; Animals; Drug Synergism; Extracellular Space; In Vitro Techniques; Kinetics; | 1993 |
Suramin inhibits growth and yet promotes insulin-like growth factor II expression in HepG2 cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Differentiation; Cell Division; Gene Expression; Glycosamin | 1993 |
Rapid, highly sensitive gradient narrow-bore high-performance liquid chromatographic determination of suramin and its analogues.
Topics: Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Sensitivity and Specificit | 1996 |
Concomitant blockade of P2X-receptors and ecto-nucleotidases by P2-receptor antagonists: functional consequences in rat vas deferens.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphatases; Adenosine Triphosphate; | 1999 |