Page last updated: 2024-11-04

suramin and Sarcoma

suramin has been researched along with Sarcoma in 4 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.

Research Excerpts

ExcerptRelevanceReference
" The antitumor effectiveness of cisplatin, paclitaxel, and suramin as single agents and in combination was evaluated in vivo against four lines of human pleural malignant mesothelioma xenografts in athymic nude mice, including one epithelial type and three fibrosarcomatous."7.70Effectiveness of cisplatin, paclitaxel, and suramin against human malignant mesothelioma xenografts in athymic nude mice. ( Chahinian, AP; Gluck, H; Holland, JF; Mandeli, JP; Naim, H; Teirstein, AS, 1998)
" The antitumor effectiveness of cisplatin, paclitaxel, and suramin as single agents and in combination was evaluated in vivo against four lines of human pleural malignant mesothelioma xenografts in athymic nude mice, including one epithelial type and three fibrosarcomatous."3.70Effectiveness of cisplatin, paclitaxel, and suramin against human malignant mesothelioma xenografts in athymic nude mice. ( Chahinian, AP; Gluck, H; Holland, JF; Mandeli, JP; Naim, H; Teirstein, AS, 1998)
"Significant neurologic toxicity can result from therapy with suramin, even when dosing is designed to avoid exposure to plasma concentrations greater than 350 micrograms/mL."2.68Pharmacologic variables associated with the development of neurologic toxicity in patients treated with suramin. ( Bitton, RJ; Bowden, C; Cooper, MR; Dalakas, MC; Figg, WD; Headlee, D; Myers, CE; Reed, E; Venzon, DJ, 1995)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's2 (50.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nylund, G1
Nordgren, S1
Delbro, DS1
Bitton, RJ1
Figg, WD1
Venzon, DJ1
Dalakas, MC1
Bowden, C1
Headlee, D1
Reed, E1
Myers, CE1
Cooper, MR1
Chahinian, AP1
Mandeli, JP1
Gluck, H1
Naim, H1
Teirstein, AS1
Holland, JF1
Mattock, NM1
Peters, W1

Trials

1 trial available for suramin and Sarcoma

ArticleYear
Pharmacologic variables associated with the development of neurologic toxicity in patients treated with suramin.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Humans; Logistic Models; Male; Melanoma; Middle Aged; Motor Neuron D

1995

Other Studies

3 other studies available for suramin and Sarcoma

ArticleYear
Expression of P2Y2 purinoceptors in MCG 101 murine sarcoma cells, and HT-29 human colon carcinoma cells.
    Autonomic neuroscience : basic & clinical, 2004, May-31, Volume: 112, Issue:1-2

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Antineoplastic Agents; Blotting, Western; Ce

2004
Effectiveness of cisplatin, paclitaxel, and suramin against human malignant mesothelioma xenografts in athymic nude mice.
    Journal of surgical oncology, 1998, Volume: 67, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Fe

1998
The experimental chemotherapy of leishmaniasis. II. The activity in tissue culture of some antiparasitic and antimicrobial compounds in clinical use.
    Annals of tropical medicine and parasitology, 1975, Volume: 69, Issue:3

    Topics: Aminoquinolines; Animals; Anti-Bacterial Agents; Antimalarials; Antimony; Antiprotozoal Agents; Asci

1975