suramin and Sarcoma
suramin has been researched along with Sarcoma in 4 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " The antitumor effectiveness of cisplatin, paclitaxel, and suramin as single agents and in combination was evaluated in vivo against four lines of human pleural malignant mesothelioma xenografts in athymic nude mice, including one epithelial type and three fibrosarcomatous." | 7.70 | Effectiveness of cisplatin, paclitaxel, and suramin against human malignant mesothelioma xenografts in athymic nude mice. ( Chahinian, AP; Gluck, H; Holland, JF; Mandeli, JP; Naim, H; Teirstein, AS, 1998) |
| " The antitumor effectiveness of cisplatin, paclitaxel, and suramin as single agents and in combination was evaluated in vivo against four lines of human pleural malignant mesothelioma xenografts in athymic nude mice, including one epithelial type and three fibrosarcomatous." | 3.70 | Effectiveness of cisplatin, paclitaxel, and suramin against human malignant mesothelioma xenografts in athymic nude mice. ( Chahinian, AP; Gluck, H; Holland, JF; Mandeli, JP; Naim, H; Teirstein, AS, 1998) |
| "Significant neurologic toxicity can result from therapy with suramin, even when dosing is designed to avoid exposure to plasma concentrations greater than 350 micrograms/mL." | 2.68 | Pharmacologic variables associated with the development of neurologic toxicity in patients treated with suramin. ( Bitton, RJ; Bowden, C; Cooper, MR; Dalakas, MC; Figg, WD; Headlee, D; Myers, CE; Reed, E; Venzon, DJ, 1995) |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Nylund, G | 1 |
| Nordgren, S | 1 |
| Delbro, DS | 1 |
| Bitton, RJ | 1 |
| Figg, WD | 1 |
| Venzon, DJ | 1 |
| Dalakas, MC | 1 |
| Bowden, C | 1 |
| Headlee, D | 1 |
| Reed, E | 1 |
| Myers, CE | 1 |
| Cooper, MR | 1 |
| Chahinian, AP | 1 |
| Mandeli, JP | 1 |
| Gluck, H | 1 |
| Naim, H | 1 |
| Teirstein, AS | 1 |
| Holland, JF | 1 |
| Mattock, NM | 1 |
| Peters, W | 1 |
Trials
1 trial available for suramin and Sarcoma
| Article | Year |
|---|---|
Pharmacologic variables associated with the development of neurologic toxicity in patients treated with suramin.
Topics: Adult; Aged; Aged, 80 and over; Humans; Logistic Models; Male; Melanoma; Middle Aged; Motor Neuron D | 1995 |
Other Studies
3 other studies available for suramin and Sarcoma
| Article | Year |
|---|---|
Expression of P2Y2 purinoceptors in MCG 101 murine sarcoma cells, and HT-29 human colon carcinoma cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Antineoplastic Agents; Blotting, Western; Ce | 2004 |
Effectiveness of cisplatin, paclitaxel, and suramin against human malignant mesothelioma xenografts in athymic nude mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Fe | 1998 |
The experimental chemotherapy of leishmaniasis. II. The activity in tissue culture of some antiparasitic and antimicrobial compounds in clinical use.
Topics: Aminoquinolines; Animals; Anti-Bacterial Agents; Antimalarials; Antimony; Antiprotozoal Agents; Asci | 1975 |