suramin has been researched along with Sarcoma, Kaposi in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Sarcoma, Kaposi: A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin was given to ten outpatients with acquired immunodeficiency syndrome (AIDS) presenting as Kaposi's sarcoma (KS) or as an AIDS-related complex (ARC)." | 3.67 | Effects of suramin on HTLV-III/LAV infection presenting as Kaposi's sarcoma or AIDS-related complex: clinical pharmacology and suppression of virus replication in vivo. ( Broder, S; Collins, JM; Gelmann, E; Hoth, DF; Klecker, RW; Lane, HC; Markham, PD; Mitsuya, H; Redfield, RR; Yarchoan, R, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Broder, S | 1 |
| Yarchoan, R | 1 |
| Collins, JM | 1 |
| Lane, HC | 1 |
| Markham, PD | 1 |
| Klecker, RW | 1 |
| Redfield, RR | 1 |
| Mitsuya, H | 1 |
| Hoth, DF | 1 |
| Gelmann, E | 1 |
| Raise, E | 1 |
| Gritti, FM | 1 |
| Bonazzi, L | 1 |
| Monti, M | 1 |
| Grillo, A | 1 |
| Savoia, M | 1 |
| Gambetti, M | 1 |
| Pulsatelli, L | 1 |
| Casertano, MG | 1 |
| Di Figlia, C | 1 |
2 other studies available for suramin and Sarcoma, Kaposi
| Article | Year |
|---|---|
Effects of suramin on HTLV-III/LAV infection presenting as Kaposi's sarcoma or AIDS-related complex: clinical pharmacology and suppression of virus replication in vivo.
Topics: Acquired Immunodeficiency Syndrome; Adult; Deltaretrovirus; Humans; Male; Middle Aged; Retroviridae | 1985 |
R-interferon alpha A and suramin sodium in the treatment of AIDS and ARC cases.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Female; Humans; Interferon Type I; | 1987 |