suramin has been researched along with Rodent Diseases in 4 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Rodent Diseases: Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The activity of diethylcarbamazine (DEC) and suramin (S) on Litomosoides carinii filariasis was assessed by the study of microfilaraemia in 30 cotton-rats (Sigmodon hispidus)." | 3.66 | Litomosoides carinii infection in cotton-rats: evolution of microfilaraemia before and after treatment with diethylcarbamazine and suramin. ( Carme, B; Gentilini, M; Lenoble, DR; Pontal, P; Smith, M, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jennings, FW | 1 |
| Urquhart, GM | 1 |
| Murray, PK | 1 |
| Miller, BM | 1 |
| Carme, B | 2 |
| Richard-Lenoble, D | 1 |
| Amgar, A | 1 |
| Danis, M | 1 |
| Gentilini, M | 2 |
| Lenoble, DR | 1 |
| Smith, M | 1 |
| Pontal, P | 1 |
| Duarte, Z | 1 |
| Gantier, JC | 1 |
| Gayral, P | 1 |
4 other studies available for suramin and Rodent Diseases
| Article | Year |
|---|---|
The use of 2-substituted 5-nitroimidazoles in the treatment of chronic murine Trypanosoma brucei infections with central nervous system involvement.
Topics: Animals; Antiprotozoal Agents; Brain; Chronic Disease; Drug Therapy, Combination; Female; Mice; Mice | 1984 |
Litomosoides carinii infection in cotton-rats before and after treatment with diethylcarbamazine and suramin: evolution of free serum antigens.
Topics: Animals; Antigens; Arvicolinae; Blood; Diethylcarbamazine; Drug Therapy, Combination; Filariasis; Ro | 1982 |
Litomosoides carinii infection in cotton-rats: evolution of microfilaraemia before and after treatment with diethylcarbamazine and suramin.
Topics: Animals; Arvicolinae; Blood; Diethylcarbamazine; Drug Therapy, Combination; Filariasis; Filarioidea; | 1981 |
Activity of albendazole-ivermectin combination and other filaricidal drugs against infective larvae, preadult, microfilariae and adult worms of Molinema dessetae in the rodent Proechimys oris.
Topics: Administration, Oral; Albendazole; Animals; Diethylcarbamazine; Drug Combinations; Female; Filariasi | 1994 |