suramin has been researched along with Retinal Pigment Epithelial Detachment in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a rabbit model of retinal detachment, early Müller glial cell reactivity was monitored-specifically, changes in membrane features-to determine whether these changes involve an upregulation of purinergic P2 receptor-mediated responses and whether all or some of these alterations could be blocked by suramin or pyridoxal phosphate 6-azophenyl-2',4'-disulfonic acid (PPADS)." | 7.72 | Early glial cell reactivity in experimental retinal detachment: effect of suramin. ( Bringmann, A; Francke, M; Goczalik, I; Pannicke, T; Reichenbach, A; Uckermann, O; Uhlmann, S; Ulbricht, E; Weick, M; Wiedemann, P, 2003) |
| "In a rabbit model of retinal detachment, early Müller glial cell reactivity was monitored-specifically, changes in membrane features-to determine whether these changes involve an upregulation of purinergic P2 receptor-mediated responses and whether all or some of these alterations could be blocked by suramin or pyridoxal phosphate 6-azophenyl-2',4'-disulfonic acid (PPADS)." | 3.72 | Early glial cell reactivity in experimental retinal detachment: effect of suramin. ( Bringmann, A; Francke, M; Goczalik, I; Pannicke, T; Reichenbach, A; Uckermann, O; Uhlmann, S; Ulbricht, E; Weick, M; Wiedemann, P, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uhlmann, S | 1 |
| Bringmann, A | 1 |
| Uckermann, O | 1 |
| Pannicke, T | 1 |
| Weick, M | 1 |
| Ulbricht, E | 1 |
| Goczalik, I | 1 |
| Reichenbach, A | 1 |
| Wiedemann, P | 1 |
| Francke, M | 1 |
1 other study available for suramin and Retinal Pigment Epithelial Detachment
| Article | Year |
|---|---|
Early glial cell reactivity in experimental retinal detachment: effect of suramin.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Membrane; Female; Hyaluronic Acid; Male; Membrane Pot | 2003 |