suramin has been researched along with Recrudescence in 12 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Relapses were significantly correlated with intrathecal IgM synthesis (odds ratio [OR], 46; 95% confidence interval [CI], 8 to 260), a CSF IgM concentration of >or=1." | 1.34 | Treatment failure related to intrathecal immunoglobulin M (IgM) synthesis, cerebrospinal fluid IgM, and interleukin-10 in patients with hemolymphatic-stage sleeping sickness. ( Bisser, S; Boelaert, M; Büscher, P; Hoogstoel, A; Lejon, V; Mumba, D; N'Siesi, FX; Reiber, H; Robays, J, 2007) |
| "Chemotherapy for human African trypanosomiasis (HAT), or sleeping sickness, is unreliable because of resistance, refraction and toxic and adverse side-effects." | 1.30 | Megazol combined with suramin: a chemotherapy regimen which reversed the CNS pathology in a model of human African trypanosomiasis in mice. ( Bouteille, B; Chauvière, G; Dumas, M; Enanga, B; Keita, M, 1998) |
| "Mel-B was used to treat 55 relapses after suramin therapy with 1." | 1.28 | Treatment of Rhodesian sleeping sickness in Kenya. ( Abinya, A; Chumo, DA; Dola, S; Mbwabi, D; Reardon, MJ; Siongok, TA; Smith, DH; Wanyama, L; Wellde, BT, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (41.67) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kibona, SN | 1 |
| Matemba, L | 1 |
| Kaboya, JS | 1 |
| Lubega, GW | 1 |
| Lejon, V | 1 |
| Robays, J | 1 |
| N'Siesi, FX | 1 |
| Mumba, D | 1 |
| Hoogstoel, A | 1 |
| Bisser, S | 1 |
| Reiber, H | 1 |
| Boelaert, M | 1 |
| Büscher, P | 1 |
| Doua, F | 1 |
| Boa Yapo, F | 1 |
| Payne, RC | 1 |
| Sukanto, IP | 1 |
| Partoutomo, S | 1 |
| Jones, TW | 1 |
| Rasheed, Q | 1 |
| Cacchione, JG | 1 |
| Berry, J | 1 |
| Richards, F | 1 |
| Bryant, L | 1 |
| Strony, J | 1 |
| Enger, C | 1 |
| Hodgson, JM | 1 |
| Keita, M | 2 |
| Bouteille, B | 2 |
| Enanga, B | 2 |
| Vallat, JM | 1 |
| Dumas, M | 2 |
| Chauvière, G | 1 |
| Bales, JD | 1 |
| Harrison, SM | 1 |
| Mbwabi, DL | 1 |
| Schecter, PJ | 1 |
| Wellde, BT | 1 |
| Chumo, DA | 1 |
| Reardon, MJ | 1 |
| Abinya, A | 1 |
| Wanyama, L | 1 |
| Dola, S | 1 |
| Mbwabi, D | 1 |
| Smith, DH | 1 |
| Siongok, TA | 1 |
| Waitumbi, JN | 1 |
| Brown, HC | 1 |
| Jennings, FW | 1 |
| Holmes, PH | 1 |
| Duggan, AJ | 1 |
| Woo, P | 1 |
| Soltys, MA | 1 |
12 other studies available for suramin and Recrudescence
| Article | Year |
|---|---|
Drug-resistance of Trypanosoma b. rhodesiense isolates from Tanzania.
Topics: Animals; Diminazene; Drug Resistance; Humans; Mass Screening; Melarsoprol; Phenanthridines; Recurren | 2006 |
Treatment failure related to intrathecal immunoglobulin M (IgM) synthesis, cerebrospinal fluid IgM, and interleukin-10 in patients with hemolymphatic-stage sleeping sickness.
Topics: Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Biomarkers; Central Nervous System Protozoa | 2007 |
[Current therapy of trypanosomiasis].
Topics: Adenosylmethionine Decarboxylase; Animals; Arsenicals; Deoxyadenosines; Drug Resistance; Eflornithin | 1994 |
Efficacy of Cymelarsan treatment of suramin resistant Trypanosoma evansi in cattle.
Topics: Animals; Arsenicals; Cattle; Drug Resistance; Injections, Subcutaneous; Recurrence; Suramin; Treatme | 1994 |
Local intramural drug delivery using an infusion balloon following angioplasty in normal and atherosclerotic vessels.
Topics: Angioplasty, Balloon, Coronary; Animals; Arteriosclerosis; Catheterization; Coronary Artery Disease; | 1994 |
Trypanosoma brucei brucei: a long-term model of human African trypanosomiasis in mice, meningo-encephalitis, astrocytosis, and neurological disorders.
Topics: Animals; Astrocytes; Brain; Choroid Plexus; Disease Models, Animal; Female; Meninges; Meningoencepha | 1997 |
Megazol combined with suramin: a chemotherapy regimen which reversed the CNS pathology in a model of human African trypanosomiasis in mice.
Topics: Animals; Body Weight; Central Nervous System Diseases; Disease Models, Animal; Drug Evaluation, Prec | 1998 |
Treatment of arsenical refractory Rhodesian sleeping sickness in Kenya.
Topics: Adult; Animals; Arsenicals; Drug Therapy, Combination; Eflornithine; Female; Humans; Kenya; Male; Me | 1989 |
Treatment of Rhodesian sleeping sickness in Kenya.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Arsenicals; Child; Drug Resistance; Female; Fol | 1989 |
The relapse of Trypanosoma brucei brucei infections after chemotherapy in rabbits.
Topics: Amidines; Animals; Diminazene; Female; Male; Mice; Rabbits; Recurrence; Suramin; Trypanosoma brucei | 1988 |
The treatment of African trypanosomiasis.
Topics: Africa, Eastern; Africa, Western; Amidines; Arsenicals; Humans; Injections, Intramuscular; Injection | 1973 |
The effect of suramin on blood and tissue forms of Trypanosoma brucei and Trypanosoma rhodesiense.
Topics: Animals; Liver; Malaria; Mice; Rabbits; Recurrence; Spleen; Suramin; Time Factors; Trypanosoma; Tryp | 1971 |