suramin has been researched along with Protein Aggregation, Pathological in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Protein Aggregation, Pathological: A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION; POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin is a polysulphonated naphthylurea and is used as an antiprotozoal drug for African Trypanosomiasis." | 1.40 | Suramin inhibits Hsp104 ATPase and disaggregase activity. ( Castellano, LM; Shorter, J; Torrente, MP, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Torrente, MP | 1 |
| Castellano, LM | 1 |
| Shorter, J | 1 |
1 other study available for suramin and Protein Aggregation, Pathological
| Article | Year |
|---|---|
Suramin inhibits Hsp104 ATPase and disaggregase activity.
Topics: Adenosine Triphosphatases; Animals; Heat-Shock Proteins; Molecular Chaperones; Protein Aggregates; P | 2014 |