Page last updated: 2024-11-04

suramin and Pregnancy

suramin has been researched along with Pregnancy in 24 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
" This study was carried out to evaluate if inhibited angiogenesis by Suramin injections in early pregnancy may cause a condition resembling pre-eclampsia in rats."7.73Placental dysfunction in Suramin-treated rats--a new model for pre-eclampsia. ( Eriksson, UJ; Jansson, L; Lindeberg, S; Naessén, T; Nash, P; Olovsson, M; Wentzel, P, 2005)
"Suramin treatment did not affect VPA-induced upregulation of P2X4 and P2Y2 receptor expression in the hippocampus, and P2X4 receptor expression in the medial prefrontal cortex, but normalized an increased level of interleukin 6 (IL-6)."5.56Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism. ( Bambini-Junior, V; Bauer-Negrini, G; Brum Schwingel, G; Carello-Collar, G; Castillo, ARG; Corrêa-Velloso, J; Deckmann, I; Fontes-Dutra, M; Gonçalves, MCB; Gottfried, C; Hirsch, MM; Körbes-Rockenbach, M; Naaldijk, Y; Rabelo, B; Santos-Terra, J; Schneider, T; Staevie, GZ; Ulrich, H, 2020)
"Suramin treatment exerted negligible effect on the RAS pathway in the adult male offspring kidneys."5.43N-Acetylcysteine Prevents Programmed Hypertension in Male Rat Offspring Born to Suramin-Treated Mothers. ( Hsu, CN; Lee, CT; Lin, YJ; Tain, YL; Tsai, CC, 2016)
"The blood pressure of the pregnant Suramin-treated rats successively increased during pregnancy and differed by 17 mmHg at gestational day 20 compared with the pregnant control rats."3.75Angiogenesis inhibition causes hypertension and placental dysfunction in a rat model of preeclampsia. ( Carlström, M; Eriksson, UJ; Persson, AE; Skøtt, O; Wentzel, P, 2009)
"In both rat strains Suramin caused fetal growth retardation, decreased placental blood flow, and increased placental concentration of the isoprostane 8-iso-PGF(2alpha)."3.73Placental dysfunction in Suramin-treated rats: impact of maternal diabetes and effects of antioxidative treatment. ( Eriksson, UJ; Nash, P; Olovsson, M, 2005)
" This study was carried out to evaluate if inhibited angiogenesis by Suramin injections in early pregnancy may cause a condition resembling pre-eclampsia in rats."3.73Placental dysfunction in Suramin-treated rats--a new model for pre-eclampsia. ( Eriksson, UJ; Jansson, L; Lindeberg, S; Naessén, T; Nash, P; Olovsson, M; Wentzel, P, 2005)
"Suramin treatment did not affect VPA-induced upregulation of P2X4 and P2Y2 receptor expression in the hippocampus, and P2X4 receptor expression in the medial prefrontal cortex, but normalized an increased level of interleukin 6 (IL-6)."1.56Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism. ( Bambini-Junior, V; Bauer-Negrini, G; Brum Schwingel, G; Carello-Collar, G; Castillo, ARG; Corrêa-Velloso, J; Deckmann, I; Fontes-Dutra, M; Gonçalves, MCB; Gottfried, C; Hirsch, MM; Körbes-Rockenbach, M; Naaldijk, Y; Rabelo, B; Santos-Terra, J; Schneider, T; Staevie, GZ; Ulrich, H, 2020)
"Suramin treatment exerted negligible effect on the RAS pathway in the adult male offspring kidneys."1.43N-Acetylcysteine Prevents Programmed Hypertension in Male Rat Offspring Born to Suramin-Treated Mothers. ( Hsu, CN; Lee, CT; Lin, YJ; Tain, YL; Tsai, CC, 2016)
"We conclude that in preeclampsia, the decrease of relaxation responses and the decrease of cGMP content could be due to the reduction in stimulation of sGC and the decrease in cGMP levels."1.39Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model. ( Bagcivan, I; Karadas, B; Parlak, M; Temiz, TK; Turgut, B; Turgut, NH, 2013)
"Suramin is a polysulfonated naphthylurea that inhibits tumor cell proliferation and angiogenesis, but the widespread use of this drug has been limited by significant neurologic toxicity."1.31Suramin analogs inhibit human angiogenesis in vitro. ( Flattmann, GJ; Gagliardi, AR; Meyers, MO; Su, JL; Wang, YZ; Woltering, EA, 2000)
"When suramin (2-10 mg/ml) was present for the final 6 h of culture, the quantity of radioactivity measured in the yolk sac at harvesting was significantly decreased in a concentration-dependent manner."1.27Evidence that suramin and aurothiomalate are teratogenic in rat by disturbing yolk sac-mediated embryonic protein nutrition. ( Freeman, SJ; Lloyd, JB, 1986)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19909 (37.50)18.7374
1990's1 (4.17)18.2507
2000's7 (29.17)29.6817
2010's6 (25.00)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Hirsch, MM1
Deckmann, I1
Santos-Terra, J1
Staevie, GZ1
Fontes-Dutra, M1
Carello-Collar, G1
Körbes-Rockenbach, M1
Brum Schwingel, G1
Bauer-Negrini, G1
Rabelo, B1
Gonçalves, MCB1
Corrêa-Velloso, J1
Naaldijk, Y1
Castillo, ARG1
Schneider, T1
Bambini-Junior, V1
Ulrich, H1
Gottfried, C1
Beamer, E1
Kovács, G1
Sperlágh, B1
Turgut, NH2
Temiz, TK2
Turgut, B2
Karadas, B2
Parlak, M1
Bagcivan, I2
Rosania, K1
Tain, YL1
Hsu, CN1
Lee, CT1
Lin, YJ1
Tsai, CC1
Torii, M1
Sasaki, M1
Chang, YW1
Ishii, S1
Waxman, SG1
Kocsis, JD1
Rakic, P1
Hashimoto-Torii, K1
Gulturk, S1
Carlström, M1
Wentzel, P2
Skøtt, O1
Persson, AE1
Eriksson, UJ3
Nadjm, B1
Van Tulleken, C1
Macdonald, D1
Chiodini, PL1
Enrique, N1
Rebolledo, A1
Martín, P1
Roldán Palomo, AR1
Tanzi, F1
Milesi, V1
MAHONEY, LJ1
BARRIE, HJ1
Nash, P2
Olovsson, M2
Lindeberg, S1
Naessén, T1
Jansson, L1
Gritli-Linde, A1
Ruch, JV1
Mark, MP1
Lécolle, S1
Goldberg, M1
Marcondes, S1
Lafay, M1
Brohard-Bohn, B1
de Nucci, G1
Rendu, F1
Meyers, MO1
Gagliardi, AR1
Flattmann, GJ1
Su, JL1
Wang, YZ1
Woltering, EA1
Mercier-Parot, L3
Tuchmann-Duplessis, H3
Olowe, SA1
Freeman, SJ1
Lloyd, JB2
Charters, AD1
Beck, F1
Bolgert, M1

Other Studies

24 other studies available for suramin and Pregnancy

ArticleYear
Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism.
    Neuropharmacology, 2020, 05-01, Volume: 167

    Topics: Animals; Anticonvulsants; Autistic Disorder; Brain; Disease Models, Animal; Female; Locomotion; Male

2020
ATP released from astrocytes modulates action potential threshold and spontaneous excitatory postsynaptic currents in the neonatal rat prefrontal cortex.
    Brain research bulletin, 2017, Volume: 135

    Topics: Action Potentials; Adenosine Triphosphate; Animals; Animals, Newborn; Astrocytes; Cerebral Cortex; E

2017
Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model.
    Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:10

    Topics: Animals; Aorta, Thoracic; Blood Pressure; Cyclic GMP; Disease Models, Animal; Dose-Response Relation

2013
Antiparasitic drug reverses neurodevelopmental deficits.
    Lab animal, 2014, Volume: 43, Issue:8

    Topics: Animals; Antiparasitic Agents; Cell Communication; Child Development Disorders, Pervasive; Disease M

2014
N-Acetylcysteine Prevents Programmed Hypertension in Male Rat Offspring Born to Suramin-Treated Mothers.
    Biology of reproduction, 2016, Volume: 95, Issue:1

    Topics: Acetylcysteine; Animals; Arginine; Blood Pressure; Female; Fetal Development; Hydrogen Sulfide; Hype

2016
Detection of vulnerable neurons damaged by environmental insults in utero.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 02-28, Volume: 114, Issue:9

    Topics: Animals; Cerebral Cortex; Electroporation; Embryo, Mammalian; Ethanol; Female; Flow Cytometry; Gene

2017
The effect of sildenafil on the altered thoracic aorta smooth muscle responses in rat pre-eclampsia model.
    European journal of pharmacology, 2008, Jul-28, Volume: 589, Issue:1-3

    Topics: Animals; Aorta, Thoracic; Blood Pressure; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5;

2008
Angiogenesis inhibition causes hypertension and placental dysfunction in a rat model of preeclampsia.
    Journal of hypertension, 2009, Volume: 27, Issue:4

    Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Female; Heart Rate; Hypertension; Male; Pl

2009
East African trypanosomiasis in a pregnant traveler.
    Emerging infectious diseases, 2009, Volume: 15, Issue:11

    Topics: Adult; Communicable Diseases, Emerging; Female; Humans; Infant, Newborn; London; Pentamidine; Pregna

2009
Extracellular ATP induces fast and transient non-selective cationic currents and cytosolic Ca2+ changes in human umbilical artery smooth muscle cells.
    Purinergic signalling, 2012, Volume: 8, Issue:2

    Topics: Adenosine Triphosphate; Calcium; Cation Transport Proteins; Cytosol; Extracellular Fluid; Female; Hu

2012
Adrenal insufficiency after suramin treatment of pemphigus.
    British medical journal, 1950, Sep-16, Volume: 2, Issue:4680

    Topics: Adrenal Glands; Adrenal Insufficiency; Pemphigus; Pregnancy; Suramin

1950
Placental dysfunction in Suramin-treated rats: impact of maternal diabetes and effects of antioxidative treatment.
    Journal of the Society for Gynecologic Investigation, 2005, Volume: 12, Issue:3

    Topics: Animals; Antioxidants; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Electrolytes; E

2005
Placental dysfunction in Suramin-treated rats--a new model for pre-eclampsia.
    Placenta, 2005, Volume: 26, Issue:5

    Topics: Angiogenesis Inhibitors; Animals; Blood Pressure; Disease Models, Animal; Electrolytes; Endothelin-1

2005
Effects of suramin, a polyanionic drug inducing lysosomal storage disorders on tooth germs in vitro.
    Biology of the cell, 1994, Volume: 81, Issue:2

    Topics: Animals; Autoradiography; Basement Membrane; Collagen; Female; Fluorescent Antibody Technique; Lysos

1994
Platelets induce human umbilical vein endothelial cell proliferation through P-selectin.
    Life sciences, 2000, Mar-31, Volume: 66, Issue:19

    Topics: Aspirin; Blood Platelets; Cell Adhesion; Cell Division; Cell Line; Endothelium, Vascular; Female; Hu

2000
Suramin analogs inhibit human angiogenesis in vitro.
    The Journal of surgical research, 2000, Jun-15, Volume: 91, Issue:2

    Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Female; Humans; Neovascularization, Path

2000
[Trial prevention of the embryolethal properties of suramin in the mouse by adjuvant progesterone].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1975, Volume: 169, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Fetal Death; Mice; P

1975
A case of congenital trypanosomiasis in Lagos.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1975, Volume: 69, Issue:1

    Topics: Acid-Base Equilibrium; Autopsy; Brain; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; M

1975
Evidence that suramin and aurothiomalate are teratogenic in rat by disturbing yolk sac-mediated embryonic protein nutrition.
    Chemico-biological interactions, 1986, Volume: 58, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Gold Sodium Thiomalate; Pinocytosis

1986
Filariasis in immigrants in Western Australia, including a case of chyluria recurring in seven pregnancies.
    The Medical journal of Australia, 1970, Nov-14, Volume: 2, Issue:20

    Topics: Adult; Aged; Australia; Chyle; Diethylcarbamazine; Female; Filariasis; Humans; India; Lymphedema; Ma

1970
[Effect of suramine on perinatal and postnatal survival in mice].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1973, Volume: 167, Issue:12

    Topics: Abnormalities, Drug-Induced; Abortifacient Agents; Animals; Animals, Newborn; Female; Fetus; Gestati

1973
[Abortifacient and teratogenic effect of suramin, a trypanocide].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1973, Volume: 167, Issue:11

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Dose-Response Relationship, Drug; Embry

1973
Lysosomes and congenital malformations.
    The Biochemical journal, 1969, Volume: 115, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Azo Compounds; Cortisone; Female; Lysosomes; Pregnancy; Rats;

1969
[Multiple drug treatment of pemphigus. Personal technic and results after 18-year follow-up].
    Annales de medecine interne, 1970, Volume: 121, Issue:4

    Topics: Adrenal Cortex Hormones; Adult; Aged; Antimalarials; Chlorides; Chlortetracycline; Female; Follow-Up

1970