suramin and Pregnancy
suramin has been researched along with Pregnancy in 24 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was carried out to evaluate if inhibited angiogenesis by Suramin injections in early pregnancy may cause a condition resembling pre-eclampsia in rats." | 7.73 | Placental dysfunction in Suramin-treated rats--a new model for pre-eclampsia. ( Eriksson, UJ; Jansson, L; Lindeberg, S; Naessén, T; Nash, P; Olovsson, M; Wentzel, P, 2005) |
| "Suramin treatment did not affect VPA-induced upregulation of P2X4 and P2Y2 receptor expression in the hippocampus, and P2X4 receptor expression in the medial prefrontal cortex, but normalized an increased level of interleukin 6 (IL-6)." | 5.56 | Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism. ( Bambini-Junior, V; Bauer-Negrini, G; Brum Schwingel, G; Carello-Collar, G; Castillo, ARG; Corrêa-Velloso, J; Deckmann, I; Fontes-Dutra, M; Gonçalves, MCB; Gottfried, C; Hirsch, MM; Körbes-Rockenbach, M; Naaldijk, Y; Rabelo, B; Santos-Terra, J; Schneider, T; Staevie, GZ; Ulrich, H, 2020) |
| "Suramin treatment exerted negligible effect on the RAS pathway in the adult male offspring kidneys." | 5.43 | N-Acetylcysteine Prevents Programmed Hypertension in Male Rat Offspring Born to Suramin-Treated Mothers. ( Hsu, CN; Lee, CT; Lin, YJ; Tain, YL; Tsai, CC, 2016) |
| "The blood pressure of the pregnant Suramin-treated rats successively increased during pregnancy and differed by 17 mmHg at gestational day 20 compared with the pregnant control rats." | 3.75 | Angiogenesis inhibition causes hypertension and placental dysfunction in a rat model of preeclampsia. ( Carlström, M; Eriksson, UJ; Persson, AE; Skøtt, O; Wentzel, P, 2009) |
| "In both rat strains Suramin caused fetal growth retardation, decreased placental blood flow, and increased placental concentration of the isoprostane 8-iso-PGF(2alpha)." | 3.73 | Placental dysfunction in Suramin-treated rats: impact of maternal diabetes and effects of antioxidative treatment. ( Eriksson, UJ; Nash, P; Olovsson, M, 2005) |
| " This study was carried out to evaluate if inhibited angiogenesis by Suramin injections in early pregnancy may cause a condition resembling pre-eclampsia in rats." | 3.73 | Placental dysfunction in Suramin-treated rats--a new model for pre-eclampsia. ( Eriksson, UJ; Jansson, L; Lindeberg, S; Naessén, T; Nash, P; Olovsson, M; Wentzel, P, 2005) |
| "Suramin treatment did not affect VPA-induced upregulation of P2X4 and P2Y2 receptor expression in the hippocampus, and P2X4 receptor expression in the medial prefrontal cortex, but normalized an increased level of interleukin 6 (IL-6)." | 1.56 | Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism. ( Bambini-Junior, V; Bauer-Negrini, G; Brum Schwingel, G; Carello-Collar, G; Castillo, ARG; Corrêa-Velloso, J; Deckmann, I; Fontes-Dutra, M; Gonçalves, MCB; Gottfried, C; Hirsch, MM; Körbes-Rockenbach, M; Naaldijk, Y; Rabelo, B; Santos-Terra, J; Schneider, T; Staevie, GZ; Ulrich, H, 2020) |
| "Suramin treatment exerted negligible effect on the RAS pathway in the adult male offspring kidneys." | 1.43 | N-Acetylcysteine Prevents Programmed Hypertension in Male Rat Offspring Born to Suramin-Treated Mothers. ( Hsu, CN; Lee, CT; Lin, YJ; Tain, YL; Tsai, CC, 2016) |
| "We conclude that in preeclampsia, the decrease of relaxation responses and the decrease of cGMP content could be due to the reduction in stimulation of sGC and the decrease in cGMP levels." | 1.39 | Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model. ( Bagcivan, I; Karadas, B; Parlak, M; Temiz, TK; Turgut, B; Turgut, NH, 2013) |
| "Suramin is a polysulfonated naphthylurea that inhibits tumor cell proliferation and angiogenesis, but the widespread use of this drug has been limited by significant neurologic toxicity." | 1.31 | Suramin analogs inhibit human angiogenesis in vitro. ( Flattmann, GJ; Gagliardi, AR; Meyers, MO; Su, JL; Wang, YZ; Woltering, EA, 2000) |
| "When suramin (2-10 mg/ml) was present for the final 6 h of culture, the quantity of radioactivity measured in the yolk sac at harvesting was significantly decreased in a concentration-dependent manner." | 1.27 | Evidence that suramin and aurothiomalate are teratogenic in rat by disturbing yolk sac-mediated embryonic protein nutrition. ( Freeman, SJ; Lloyd, JB, 1986) |
Research
Studies (24)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (37.50) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 7 (29.17) | 29.6817 |
| 2010's | 6 (25.00) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Hirsch, MM | 1 |
| Deckmann, I | 1 |
| Santos-Terra, J | 1 |
| Staevie, GZ | 1 |
| Fontes-Dutra, M | 1 |
| Carello-Collar, G | 1 |
| Körbes-Rockenbach, M | 1 |
| Brum Schwingel, G | 1 |
| Bauer-Negrini, G | 1 |
| Rabelo, B | 1 |
| Gonçalves, MCB | 1 |
| Corrêa-Velloso, J | 1 |
| Naaldijk, Y | 1 |
| Castillo, ARG | 1 |
| Schneider, T | 1 |
| Bambini-Junior, V | 1 |
| Ulrich, H | 1 |
| Gottfried, C | 1 |
| Beamer, E | 1 |
| Kovács, G | 1 |
| Sperlágh, B | 1 |
| Turgut, NH | 2 |
| Temiz, TK | 2 |
| Turgut, B | 2 |
| Karadas, B | 2 |
| Parlak, M | 1 |
| Bagcivan, I | 2 |
| Rosania, K | 1 |
| Tain, YL | 1 |
| Hsu, CN | 1 |
| Lee, CT | 1 |
| Lin, YJ | 1 |
| Tsai, CC | 1 |
| Torii, M | 1 |
| Sasaki, M | 1 |
| Chang, YW | 1 |
| Ishii, S | 1 |
| Waxman, SG | 1 |
| Kocsis, JD | 1 |
| Rakic, P | 1 |
| Hashimoto-Torii, K | 1 |
| Gulturk, S | 1 |
| Carlström, M | 1 |
| Wentzel, P | 2 |
| Skøtt, O | 1 |
| Persson, AE | 1 |
| Eriksson, UJ | 3 |
| Nadjm, B | 1 |
| Van Tulleken, C | 1 |
| Macdonald, D | 1 |
| Chiodini, PL | 1 |
| Enrique, N | 1 |
| Rebolledo, A | 1 |
| Martín, P | 1 |
| Roldán Palomo, AR | 1 |
| Tanzi, F | 1 |
| Milesi, V | 1 |
| MAHONEY, LJ | 1 |
| BARRIE, HJ | 1 |
| Nash, P | 2 |
| Olovsson, M | 2 |
| Lindeberg, S | 1 |
| Naessén, T | 1 |
| Jansson, L | 1 |
| Gritli-Linde, A | 1 |
| Ruch, JV | 1 |
| Mark, MP | 1 |
| Lécolle, S | 1 |
| Goldberg, M | 1 |
| Marcondes, S | 1 |
| Lafay, M | 1 |
| Brohard-Bohn, B | 1 |
| de Nucci, G | 1 |
| Rendu, F | 1 |
| Meyers, MO | 1 |
| Gagliardi, AR | 1 |
| Flattmann, GJ | 1 |
| Su, JL | 1 |
| Wang, YZ | 1 |
| Woltering, EA | 1 |
| Mercier-Parot, L | 3 |
| Tuchmann-Duplessis, H | 3 |
| Olowe, SA | 1 |
| Freeman, SJ | 1 |
| Lloyd, JB | 2 |
| Charters, AD | 1 |
| Beck, F | 1 |
| Bolgert, M | 1 |
Other Studies
24 other studies available for suramin and Pregnancy
| Article | Year |
|---|---|
Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism.
Topics: Animals; Anticonvulsants; Autistic Disorder; Brain; Disease Models, Animal; Female; Locomotion; Male | 2020 |
ATP released from astrocytes modulates action potential threshold and spontaneous excitatory postsynaptic currents in the neonatal rat prefrontal cortex.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Animals, Newborn; Astrocytes; Cerebral Cortex; E | 2017 |
Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cyclic GMP; Disease Models, Animal; Dose-Response Relation | 2013 |
Antiparasitic drug reverses neurodevelopmental deficits.
Topics: Animals; Antiparasitic Agents; Cell Communication; Child Development Disorders, Pervasive; Disease M | 2014 |
N-Acetylcysteine Prevents Programmed Hypertension in Male Rat Offspring Born to Suramin-Treated Mothers.
Topics: Acetylcysteine; Animals; Arginine; Blood Pressure; Female; Fetal Development; Hydrogen Sulfide; Hype | 2016 |
Detection of vulnerable neurons damaged by environmental insults in utero.
Topics: Animals; Cerebral Cortex; Electroporation; Embryo, Mammalian; Ethanol; Female; Flow Cytometry; Gene | 2017 |
The effect of sildenafil on the altered thoracic aorta smooth muscle responses in rat pre-eclampsia model.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; | 2008 |
Angiogenesis inhibition causes hypertension and placental dysfunction in a rat model of preeclampsia.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Female; Heart Rate; Hypertension; Male; Pl | 2009 |
East African trypanosomiasis in a pregnant traveler.
Topics: Adult; Communicable Diseases, Emerging; Female; Humans; Infant, Newborn; London; Pentamidine; Pregna | 2009 |
Extracellular ATP induces fast and transient non-selective cationic currents and cytosolic Ca2+ changes in human umbilical artery smooth muscle cells.
Topics: Adenosine Triphosphate; Calcium; Cation Transport Proteins; Cytosol; Extracellular Fluid; Female; Hu | 2012 |
Adrenal insufficiency after suramin treatment of pemphigus.
Topics: Adrenal Glands; Adrenal Insufficiency; Pemphigus; Pregnancy; Suramin | 1950 |
Placental dysfunction in Suramin-treated rats: impact of maternal diabetes and effects of antioxidative treatment.
Topics: Animals; Antioxidants; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Electrolytes; E | 2005 |
Placental dysfunction in Suramin-treated rats--a new model for pre-eclampsia.
Topics: Angiogenesis Inhibitors; Animals; Blood Pressure; Disease Models, Animal; Electrolytes; Endothelin-1 | 2005 |
Effects of suramin, a polyanionic drug inducing lysosomal storage disorders on tooth germs in vitro.
Topics: Animals; Autoradiography; Basement Membrane; Collagen; Female; Fluorescent Antibody Technique; Lysos | 1994 |
Platelets induce human umbilical vein endothelial cell proliferation through P-selectin.
Topics: Aspirin; Blood Platelets; Cell Adhesion; Cell Division; Cell Line; Endothelium, Vascular; Female; Hu | 2000 |
Suramin analogs inhibit human angiogenesis in vitro.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Female; Humans; Neovascularization, Path | 2000 |
[Trial prevention of the embryolethal properties of suramin in the mouse by adjuvant progesterone].
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Fetal Death; Mice; P | 1975 |
A case of congenital trypanosomiasis in Lagos.
Topics: Acid-Base Equilibrium; Autopsy; Brain; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; M | 1975 |
Evidence that suramin and aurothiomalate are teratogenic in rat by disturbing yolk sac-mediated embryonic protein nutrition.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Gold Sodium Thiomalate; Pinocytosis | 1986 |
Filariasis in immigrants in Western Australia, including a case of chyluria recurring in seven pregnancies.
Topics: Adult; Aged; Australia; Chyle; Diethylcarbamazine; Female; Filariasis; Humans; India; Lymphedema; Ma | 1970 |
[Effect of suramine on perinatal and postnatal survival in mice].
Topics: Abnormalities, Drug-Induced; Abortifacient Agents; Animals; Animals, Newborn; Female; Fetus; Gestati | 1973 |
[Abortifacient and teratogenic effect of suramin, a trypanocide].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Dose-Response Relationship, Drug; Embry | 1973 |
Lysosomes and congenital malformations.
Topics: Abnormalities, Drug-Induced; Animals; Azo Compounds; Cortisone; Female; Lysosomes; Pregnancy; Rats; | 1969 |
[Multiple drug treatment of pemphigus. Personal technic and results after 18-year follow-up].
Topics: Adrenal Cortex Hormones; Adult; Aged; Antimalarials; Chlorides; Chlortetracycline; Female; Follow-Up | 1970 |