suramin has been researched along with Precursor Cell Lymphoblastic Leukemia-Lymphoma in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hosoi, Y | 1 |
| Matsumoto, Y | 1 |
| Tomita, M | 1 |
| Enomoto, A | 1 |
| Morita, A | 1 |
| Sakai, K | 1 |
| Umeda, N | 1 |
| Zhao, HJ | 1 |
| Nakagawa, K | 1 |
| Ono, T | 1 |
| Suzuki, N | 1 |
1 other study available for suramin and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Phosphorothioate oligonucleotides, suramin and heparin inhibit DNA-dependent protein kinase activity.
Topics: Antineoplastic Agents; Cell Culture Techniques; DNA Damage; DNA Repair; DNA-Activated Protein Kinase | 2002 |