suramin has been researched along with Pre-Eclampsia in 5 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Pre-Eclampsia: A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was carried out to evaluate if inhibited angiogenesis by Suramin injections in early pregnancy may cause a condition resembling pre-eclampsia in rats." | 7.73 | Placental dysfunction in Suramin-treated rats--a new model for pre-eclampsia. ( Eriksson, UJ; Jansson, L; Lindeberg, S; Naessén, T; Nash, P; Olovsson, M; Wentzel, P, 2005) |
| "Suramin treatment exerted negligible effect on the RAS pathway in the adult male offspring kidneys." | 5.43 | N-Acetylcysteine Prevents Programmed Hypertension in Male Rat Offspring Born to Suramin-Treated Mothers. ( Hsu, CN; Lee, CT; Lin, YJ; Tain, YL; Tsai, CC, 2016) |
| "The blood pressure of the pregnant Suramin-treated rats successively increased during pregnancy and differed by 17 mmHg at gestational day 20 compared with the pregnant control rats." | 3.75 | Angiogenesis inhibition causes hypertension and placental dysfunction in a rat model of preeclampsia. ( Carlström, M; Eriksson, UJ; Persson, AE; Skøtt, O; Wentzel, P, 2009) |
| " This study was carried out to evaluate if inhibited angiogenesis by Suramin injections in early pregnancy may cause a condition resembling pre-eclampsia in rats." | 3.73 | Placental dysfunction in Suramin-treated rats--a new model for pre-eclampsia. ( Eriksson, UJ; Jansson, L; Lindeberg, S; Naessén, T; Nash, P; Olovsson, M; Wentzel, P, 2005) |
| "Suramin treatment exerted negligible effect on the RAS pathway in the adult male offspring kidneys." | 1.43 | N-Acetylcysteine Prevents Programmed Hypertension in Male Rat Offspring Born to Suramin-Treated Mothers. ( Hsu, CN; Lee, CT; Lin, YJ; Tain, YL; Tsai, CC, 2016) |
| "We conclude that in preeclampsia, the decrease of relaxation responses and the decrease of cGMP content could be due to the reduction in stimulation of sGC and the decrease in cGMP levels." | 1.39 | Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model. ( Bagcivan, I; Karadas, B; Parlak, M; Temiz, TK; Turgut, B; Turgut, NH, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Turgut, NH | 2 |
| Temiz, TK | 2 |
| Turgut, B | 2 |
| Karadas, B | 2 |
| Parlak, M | 1 |
| Bagcivan, I | 2 |
| Tain, YL | 1 |
| Hsu, CN | 1 |
| Lee, CT | 1 |
| Lin, YJ | 1 |
| Tsai, CC | 1 |
| Gulturk, S | 1 |
| Carlström, M | 1 |
| Wentzel, P | 2 |
| Skøtt, O | 1 |
| Persson, AE | 1 |
| Eriksson, UJ | 2 |
| Nash, P | 1 |
| Lindeberg, S | 1 |
| Naessén, T | 1 |
| Jansson, L | 1 |
| Olovsson, M | 1 |
5 other studies available for suramin and Pre-Eclampsia
| Article | Year |
|---|---|
Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cyclic GMP; Disease Models, Animal; Dose-Response Relation | 2013 |
N-Acetylcysteine Prevents Programmed Hypertension in Male Rat Offspring Born to Suramin-Treated Mothers.
Topics: Acetylcysteine; Animals; Arginine; Blood Pressure; Female; Fetal Development; Hydrogen Sulfide; Hype | 2016 |
The effect of sildenafil on the altered thoracic aorta smooth muscle responses in rat pre-eclampsia model.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; | 2008 |
Angiogenesis inhibition causes hypertension and placental dysfunction in a rat model of preeclampsia.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Female; Heart Rate; Hypertension; Male; Pl | 2009 |
Placental dysfunction in Suramin-treated rats--a new model for pre-eclampsia.
Topics: Angiogenesis Inhibitors; Animals; Blood Pressure; Disease Models, Animal; Electrolytes; Endothelin-1 | 2005 |