suramin has been researched along with Pneumonia, Pneumocystis in 2 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Pneumonia, Pneumocystis: A pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by DYSPNEA, tachypnea, and HYPOXEMIA. Pneumocystis pneumonia is a frequently seen opportunistic infection in AIDS. It is caused by the fungus PNEUMOCYSTIS JIROVECII. The disease is also found in other MAMMALS where it is caused by related species of Pneumocystis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin and dapsone were weakly active." | 1.27 | Efficacy of DL-alpha-difluoromethylornithine in a rat model of Pneumocystis carinii pneumonia. ( Clarkson, AB; Rosenberg, C; Williams, DE, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takada, S | 1 |
| Clarkson, AB | 1 |
| Williams, DE | 1 |
| Rosenberg, C | 1 |
2 other studies available for suramin and Pneumonia, Pneumocystis
| Article | Year |
|---|---|
[Drugs used against protozoan infections in man].
Topics: Amebiasis; Aminoquinolines; Antiprotozoal Agents; Humans; Malaria; Metronidazole; Pneumonia, Pneumoc | 1990 |
Efficacy of DL-alpha-difluoromethylornithine in a rat model of Pneumocystis carinii pneumonia.
Topics: Amphotericin B; Animals; Antiprotozoal Agents; Dapsone; Diminazene; Disease Models, Animal; Drug Com | 1988 |